Hydrology and the Imperial Vision of Bois de Boulogne

Bois de Boulogne was a key urban design effort of Second Empire France. This essay surveys the landscape of the park with particular attention to water; social practices that engendered the use of water, and social practices which water enabled. The hydrology of the site – the grand lake, streams, and waterfalls – is a statement and demonstration of imperial mastery and sensibility. Nearly half of the project budget was devoted to hydraulics and, in the opening years, more than 15% of the municipal water supply was diverted to the park; all of which supported a statusladen array of features attractive to elites of the Second Empire and Third Republic

The three A's in asthma - airway smooth muscle, airway remodeling & angiogenesis

Asthma affects more than 300 million people worldwide and its prevalence is still rising. Acute asthma attacks are characterized by severe symptoms such as breathlessness, wheezing, tightness of the chest, and coughing, which may lead to hospitalization or death. Besides the acute symptoms, asthma is characterized by persistent airway inflammation and airway wall remodeling. The term airway wall remodeling summarizes the structural changes in the airway wall: epithelial cell shedding, goblet cell hyperplasia, hyperplasia and hypertrophy of the airway smooth muscle (ASM) bundles, basement membrane thickening and increased vascular density. Airway wall remodeling starts early in the pathogenesis of asthma and today it is suggested that remodeling is a prerequisite for other asthma pathologies. The beneficial effect of bronchial thermoplasty in reducing asthma symptoms, together with the increased potential of ASM cells of asthmatics to produce inflammatory and angiogenic factors, indicate that the ASM cell is a major effector cell in the pathology of asthma. In the present review we discuss the ASM cell and its role in airway wall remodeling and angiogenesis