ALMA imaging of SDP.81 - I. A pixelated reconstruction of the far-infrared continuum emission

We present a sub-50 pc-scale analysis of the gravitational lens system SDP.81 at redshift 3.042 using Atacama Large Millimetre/submillimetre Array (ALMA) science verification data. We model both the mass distribution of the gravitational lensing galaxy and the pixelated surface brightness distribution of the background source using a novel Bayesian technique that fits the data directly in visibility space. We find the 1 and 1.3 mm dust emission to be magnified by a factor of u_tot = 17.6+/-0.4, giving an intrinsic total star-formation rate of 315+/-60 M_sol/yr and a dust mass of 6.4+/-1.5*10^8 M_sol. The reconstructed dust emission is found to be non-uniform, but composed of multiple regions that are heated by both diffuse and strongly clumped star-formation. The highest surface brightness region is a ~1.9*0.7 kpc disk-like structure, whose small extent is consistent with a potential size-bias in gravitationally lensed starbursts. Although surrounded by extended star formation, with a density of 20-30+/-10 M_sol/yr/kpc^2, the disk contains three compact regions with densities that peak between 120-190+/-20 M_sol/yr/kpc^2. Such star-formation rate densities are below what is expected for Eddington-limited star-formation by a radiation pressure supported starburst. There is also a tentative variation in the spectral slope of the different star-forming regions, which is likely due to a change in the dust temperature and/or opacity across the source.Comment: MNRAS accepted 2015 April 1

ALMA imaging of SDP.81 - II. A pixelated reconstruction of the CO emission lines

We present a sub-100 pc-scale analysis of the CO molecular gas emission and kinematics of the gravitational lens system SDP.81 at redshift 3.042 using Atacama Large Millimetre/submillimetre Array (ALMA) science verification data and a visibility-plane lens reconstruction technique. We find clear evidence for an excitation dependent structure in the unlensed molecular gas distribution, with emission in CO (5-4) being significantly more diffuse and structured than in CO (8-7). The intrinsic line luminosity ratio is r_8-7/5-4 = 0.30 +/- 0.04, which is consistent with other low-excitation starbursts at z ~ 3. An analysis of the velocity fields shows evidence for a star-forming disk with multiple velocity components that is consistent with a merger/post-coalescence merger scenario, and a dynamical mass of M(< 1.56 kpc) = 1.6 +/- 0.6 x 10^10 M_sol . Source reconstructions from ALMA and the Hubble Space Telescope show that the stellar component is offset from the molecular gas and dust components. Together with Karl G. Jansky Very Large Array CO (1-0) data, they provide corroborative evidence for a complex ~2 kpc-scale starburst that is embedded within a larger ~15 kpc structure.Comment: MNRAS accepted, 6th July 201

Pharmacologic and Bacteriologic Properties of SCH‐27899 (Ziracin), an Investigational Antibiotic from the Everninomicin Family

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90360/1/phco.19.15.1111.30576.pd

On upscaling heat conductivity for a class of industrial problems

Calculating effective heat conductivity for a class of industrial problems is discussed. The considered composite materials are glass and metal foams, fibrous materials, and the like, used in isolation or in advanced heat exchangers. These materials are characterized by a very complex internal structure, by low volume fraction of the higher conductive material (glass or metal), and by a large volume fraction of the air. The homogenization theory (when applicable), allows to calculate the effective heat conductivity of composite media by postprocessing the solution of special cell problems for representative elementary volumes (REV). Different formulations of such cell problems are considered and compared here. Furthermore, the size of the REV is studied numerically for some typical materials. Fast algorithms for solving the cell problems for this class of problems, are presented and discussed

Novel Daptomycin Combinations against Daptomycin-Nonsusceptible Methicillin-Resistant Staphylococcus aureus in an In Vitro Model of Simulated Endocardial Vegetations

Reduced susceptibility to daptomycin has been reported in patients with infections due to methicillin-resistant Staphylococcus aureus (MRSA). Although infections with daptomycin-nonsusceptible (DNS) MRSA are infrequent, optimal therapy of these strains has not been determined. We investigated the killing effects of novel antibiotic combinations with daptomycin (DAP) against two clinical DNS MRSA isolates (SA-684 and R6003) in a 72-h in vitro pharmacokinetic/pharmacodynamic (PK/PD) model with simulated endocardial vegetations (SEV). Simulated regimens included DAP at 6 mg/kg every 24 h (q24h) alone or in combination with trimethoprim-sulfamethoxazole (TMP/SMX) at 160/800 mg q12h, linezolid (LIN) at 600 mg q12h, cefepime (CEF) at 2 g q12h, and nafcillin (NAF) at 4 g q4h. Bactericidal activity was defined as a ≥3-log10 CFU/g kill. Differences in CFU/g were evaluated between 4 and 72 h by analysis of variance with the Bonferroni post hoc test. DAP MICs were 4 and 2 mg/liter for SA-684 and R6003, respectively. In the PK/PD model, DAP alone was slowly bactericidal, achieving a 3-log10 kill at 24 and 50 h for SA-684 and R6003, respectively. Against SA-684, DAP plus TMP/SMX, CEF, LIN, or NAF was bactericidal at 4, 4, 8, and 8 h, respectively, and maintained this activity for the 72-h study duration. DAP plus TMP/SMX or CEF exhibited superior killing than DAP alone against SA-684 between 4 and 72 h, and overall this was significant (P < 0.05). Against R6003, DAP plus TMP/SMX was bactericidal (8 h) and superior to DAP alone between 8 and 72 h (P < 0.001). The unique combination of DAP plus TMP/SMX was the most effective and rapidly bactericidal regimen against the two isolates tested and may provide a clinical option to treat DNS S. aureus infections.This work was not funded by any external support. M.J.R. has received grant support, consulted for, or provided lectures for Astellas, Cubist, Forrest, Ortho-McNeil, and Pfizer