1 research outputs found
An Improved Synthesis of <sup>Me4</sup>PCP and DMPE
No full textWe present a new
synthetic method for the bis(dimethyl)phosphines <sup>Me4</sup>PCP
(C<sub>6</sub>H<sub>4</sub>-2,6-(CH<sub>2</sub>P(CH<sub>3</sub>)<sub>2</sub>)<sub>2</sub>) and DMPE
((CH<sub>3</sub>)<sub>2</sub>PCH<sub>2</sub>CH<sub>2</sub>P(CH<sub>3</sub>)<sub>2</sub>) that starts from an aminophosphine,
Et<sub>2</sub>NPMe<sub>2</sub>. Two equivalents of Et<sub>2</sub>NPMe<sub>2</sub> react with the corresponding bis(alkyl bromide) to afford
an oxygen- and moisture-stable aminophosphonium salt. NaAlH<sub>4</sub> selectively reduces the aminophosphonium salt to the desired phosphine.
Each step is high yielding and requires minimal purification
