38 research outputs found
EMSL Pore Scale Modeling Challenge/Workshop
Report covers the background for the workshop, objectives, important research directions, necessary capabilities and overall recommendations
The genetic architecture of type 2 diabetes
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified scores of common variants associated with type 2 diabetes, but in aggregate, these explain only a fraction of heritability. To test the hypothesis that lower-frequency variants explain much of the remainder, the GoT2D and T2D-GENES consortia performed whole genome sequencing in 2,657 Europeans with and without diabetes, and exome sequencing in a total of 12,940 subjects from five ancestral groups. To increase statistical power, we expanded sample size via genotyping and imputation in a further 111,548 subjects. Variants associated with type 2 diabetes after sequencing were overwhelmingly common and most fell within regions previously identified by genome-wide association studies. Comprehensive enumeration of sequence variation is necessary to identify functional alleles that provide important clues to disease pathophysiology, but large-scale sequencing does not support a major role for lower-frequency variants in predisposition to type 2 diabetes
Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo
Meeting Abstracts: Proceedings of the Thirteenth International Society of Sports Nutrition (ISSN) Conference and Expo Clearwater Beach, FL, USA. 9-11 June 201
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Citrus Orchard Floor Management 2001-2003: Comparison of a Disk, “Perfecta” Cultivator, and Weed Sensing Sprayer
An optical weed sensing sprayer (WeedSeeker) was evaluated for making postemergence glyphosate herbicide applications in a Yuma, AZ lemon orchard. In addition, mechanical (disk and Perfecta cultivator) and chemical weed control strategies were compared. Results were fairly similar; however, the use of the WeedSeeker units combined with a preemergence herbicide (H1) increased weed control three fold compared to disking (D) and perfecta (P1). Additionally, when the WeedSeeker units were used in conjunction with preemergence herbicides, spray volume was reduced by 66% compared to a conventional sprayer and by 57% when used for postemergence applications only. There was a relationship between weed ground cover and the area sprayed by the WeedSeeker units indicating that maximum postemergence herbicide savings will occur at low weed densities or less than 10% groundcover. The use of a sprayer with an improved suspension system allowed for faster spraying speeds than were possible with the tractor mounted sprayer. Weed control was similar for the conventional and the WeedSeeker sprayer. However, yields were variable for both years. Future investigations will include efforts to develop crop budgets based on experimental operationsArizona Citrus Research Counci