Clinical evaluation and treatment of phaeochromocytoma

Phaeochromocytoma and extra adrenal paraganglioma are rare neuroendocrine tumours and have the potential to secrete adrenaline, noradrenaline and dopamine causing a myriad of clinical symptoms. Prompt diagnosis is essential for clinicians and requires a multidisciplinary specialist approach for the clinical and laboratory investigation, diagnosis, treatment and follow-up of patients. This paper is an integrated review of the clinical and laboratory evaluation and treatment of patients suspected to have phaeochromocytoma or paraganglioma, highlighting recent developments and best practices from recent published clinical guidelines.</jats:p

A novel panel of differentially-expressed microRNAs in breast cancer brain metastasis may predict patient survival

Breast cancer brain metastasis (BCBM) is an area of unmet clinical need. MicroRNAs (miRNAs) have been linked to the metastatic process in breast cancer (BC). In this study, we aim to determine differentially-expressed miRNAs utilising primary BCs that did not relapse (BCNR, n = 12), primaries that relapsed (BCR) and their paired (n = 40 pairs) brain metastases (BM) using the NanoString™ nCounter™ miRNA Expression Assays. Significance analysis of microarrays identified 58 and 11 differentially-expressed miRNAs between BCNR vs BCR and BCR vs BM respectively and pathway analysis revealed enrichment for genes involved in invasion and metastasis. Four miRNAs, miR-132-3p, miR-199a-5p, miR-150-5p and miR-155-5p, were differentially-expressed within both cohorts (BCNR-BCR, BCR-BM) and receiver-operating characteristic curve analysis (p = 0.00137) and Kaplan-Meier survival method (p = 0.0029, brain metastasis-free survival; p = 0.0007, overall survival) demonstrated their potential use as prognostic markers. Ingenuity pathway enrichment linked them to the MET oncogene, and the cMET protein was overexpressed in the BCR (p < 0.0001) and BM (p = 0.0008) cases, compared to the BCNRs. The 4-miRNAs panel identified in this study could be potentially used to distinguish BC patients with an increased risk of developing BCBM and provide potential novel therapeutic targets, whereas cMET-targeting warrants further investigation in the treatment of BCBM

Reports and commentaries: Robert Jones Prize in Orthopaedic Surgery, 1950

Oase No.I.Supracondylar and Intercondylar fracture of Femur in a boy of 20. || Case. No.2.Supracondylar and Intercondylar fracture of Humerus in a man of 28. || Case No.3.Supracondylar fracture of Femur in a child of 3. || Case No.4.Abduction impacted fracture of the neck of the Femur and avascular necrosis of the femoral head in a woman of 53. || Case No.5.Perthes disease in a boy of 9. || Case No.6.Scheurerrnann's disease in a boy of 17

Notes on the period of post-depositional development in several common lizards

http://deepblue.lib.umich.edu/bitstream/2027.42/56680/1/OP241.pd