Additional file 4: of Mitochondrial DNA copy number variation, leukocyte telomere length, and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Table S4. Associations between mtDNA integrity (ND4/ND1 divided by ND1/nuclear genome) and BC risk. (DOCX 15 kb

DNA extraction generated in the course of 12 distinct projects using specimens of the EPIC cohort.

<p>DNA extraction generated in the course of 12 distinct projects using specimens of the EPIC cohort.</p

Effects of individual characteristics and processing variations on DNA yield (µg).

c<p>The estimated coefficients for effect reflect the increasing (positive value) or decreasing (negative value) concentration response to the lifestyle/exposure factor, adjusted for the other lifestyle/exposure factors.</p

Qualification for different genotyping method.

<p>Qualification for different genotyping method.</p

Additional file 1: of Metabolomic profiles of hepatocellular carcinoma in a European prospective cohort

Supplementary methods for NMR metabolomics data acquisition, additional table (Table S1. Metabolites identified in serum samples) and additional figures (Figure S1. Validation (1000 resampling) of the O-PLS model based on 1H CPMG spectra and O-PLS metabolic signature obtained from the analysis of 1H NOESY NMR spectra. Figure S2. Validation (1000 resampling) of the O-PLS models stratified by hepatitis infection status of the cases, and liver function score. Figure S3. Validation (1000 resampling) of the O-PLS models stratified by lag time between blood collection and diagnosis). (PDF 684 kb

Distribution of yield (µg) for DNA samples extracted with 2 aliquots of buffy coat.

<p>Representation of DNA yield for DNA extractions performed from 2 buffy coat aliquots. Boxes extend from 25^th to 75^th percentiles and are divided by a solid line representing the median of each center. Whiskers extend from lower to upper adjacent values as defined by Tukey. Outliers are denoted by a dot.</p

A Scale Map of the 26 SNPs Genotyped in the MEC Screening Panel and a Plot of the Pattern of Linkage Disequilibrium among Them (in Whites)

<p>The four tag SNPs are markers with arrows, and the block of high linkage disequilibrium and limited haplotype diversity spanning <i>HSD17B1</i> is highlighted.</p