Hawthorne's use of setting in his novels

Thesis (M.A.)--University of Kansas, English, 1925

Letter written by Ruth J. McBride to her son

A letter written by a mother to her son, Thomas, in which she is describing how her other son, Wilson, is ignoring her; Ruth also tells Thomas that she is in need of money and asks if he would send her some money.https://scholars.fhsu.edu/tj_ks_territorial_docs/1015/thumbnail.jp

The role of Severe Acute Respiratory Syndrome (SARS)-Coronavirus Accessory Proteins in Virus Pathogenesis

A respiratory disease caused by a novel coronavirus, termed the severe acute respiratory syndrome coronavirus (SARS-CoV), was first reported in China in late 2002. The subsequent efficient human-to-human transmission of this virus eventually affected more than 30 countries worldwide, resulting in a mortality rate of ~10% of infected individuals. The spread of the virus was ultimately controlled by isolation of infected individuals and there has been no infections reported since April 2004. However, the natural reservoir of the virus was never identified and it is not known if this virus will re-emerge and, therefore, research on this virus continues. The SARS-CoV genome is about 30 kb in length and is predicted to contain 14 functional open reading frames (ORFs). The genome encodes for proteins that are homologous to known coronavirus proteins, such as the replicase proteins (ORFs 1a and 1b) and the four major structural proteins: nucleocapsid (N), spike (S), membrane (M) and envelope (E). SARS-CoV also encodes for eight unique proteins, called accessory proteins, with no known homologues. This review will summarize the current knowledge on SARS-CoV accessory proteins and will include: (i) expression and processing; (ii) the effects on cellular processes; and (iii) functional studies.Web of Scienc

The Coronavirus Nucleocapsid is a Multifunctional Protein

The coronavirus nucleocapsid (N) is a structural protein that forms complexes with genomic RNA, interacts with the viral membrane protein during virion assembly and plays a critical role in enhancing the efficiency of virus transcription and assembly. Recent studies have confirmed that N is a multifunctional protein. The aim of this review is to highlight the properties and functions of the N protein, with specific reference to (i) the topology; (ii) the intracellular localization and (iii) the functions of the protein.Web of Scienc

The Lantern Vol. 3, No. 3, June 1935

• Scholarship\u27s Reward • Thus Endeth • Even in Dover • An Essay Submitted for the Paisley Prize: The Moral Standard to Which We Must Appeal in Judging Whether a Lie is Ever Justifiable • Towers of France • An Essay Submitted for the Paisley Prize • Initial Adventures in Psychiatry • In Commemoration of Comus • The Amish Maidenhttps://digitalcommons.ursinus.edu/lantern/1006/thumbnail.jp

The Iowa Homemaker vol.35, no.7

New England by Garfield, Mary Vandecar, page 5 Where else but at college?, Ruth Abbott, page 6 Kitchen formula #1: recipes, Pat McBride, page 7 Our Des Moines apartment, Marilyn Martin, page 8 Our near-campus apartment, Barbara Culver, page 9 Practice makes prize-winning pies, Sally Rosenquist Bennett, page 10 New life for the landings, Lee Klinzman, page 12 What’s New, Mary Anne Larson, page 13 Trends – Scandinavian art, Donna Danielson, page 1

Profiling of transcriptional and epigenetic changes during directed endothelial differentiation of human embryonic stem cells identifies FOXA2 as a marker of early mesoderm commitment

Introduction: Differentiation of vascular endothelial cells (ECs) in clinically relevant numbers for injection into ischaemic areas could offer therapeutic potential in the treatment of cardiovascular conditions, including myocardial infarction, peripheral vascular disease and stroke. While we and others have demonstrated successful generation of functional endothelial-like cells from human embryonic stem cells (hESCs), little is understood regarding the complex transcriptional and epigenetic changes that occur during differentiation, in particular during early commitment to a mesodermal lineage. Methods: We performed the first gene expression microarray study of hESCs undergoing directed differentiation to ECs using a monolayer-based, feeder-free and serum-free protocol. Microarray results were confirmed by quantitative RT-PCR and immunocytochemistry, and chromatin immunoprecipitation (ChIP)-PCR analysis was utilised to determine the bivalent status of differentially expressed genes. Results: We identified 22 transcription factors specific to early mesoderm commitment. Among these factors, FOXA2 was observed to be the most significantly differentially expressed at the hESC–EC day 2 timepoint. ChIP-PCR analysis revealed that the FOXA2 transcription start site is bivalently marked with histone modifications for both gene activation (H3K4me3) and repression (H3K27me3) in hESCs, suggesting the transcription factor may be a key regulator of hESC differentiation. Conclusion: This enhanced knowledge of the lineage commitment process will help improve the design of directed differentiation protocols, increasing the yield of endothelial-like cells for regenerative medicine therapies in cardiovascular disease

The Lantern Vol. 3, No. 1, December 1934

• Magic Words • The Old Trappe Church • The Light of Life • Edwin Markham: Impressions • Increment (A Christmas Thought) • Our Christmas • What Price Forgetting? • Autumn • The Old Parson • Zacharias Ursinus • Inspiration • A Scrap-Book of Memories • A Campus Saunterhttps://digitalcommons.ursinus.edu/lantern/1004/thumbnail.jp

The Lantern Vol. 3, No. 2, March 1935

• Puppets of Propaganda • Reluctance • Reflections From My Diary • Reverie • Bash Turner Enters the Limelight • The College Students\u27 Obligation • The Schwenkfelders • Love\u27s Desire • Verse • On the Squirt of a Grapefruit • Pioneers! • Whither Fraternities? • Mary Peters: A Book Review • Different as Night and Day • Ode to an Alley Cathttps://digitalcommons.ursinus.edu/lantern/1005/thumbnail.jp