Simulationsgestützte Planung und Auslegung hybrider AC/DCEnergienetze für Produktionssysteme: ein ganzheitlicher Ansatz

This paper proposes a simulation-based planning concept and a simulation architecture for the design of hybrid AC/DC grids, which have the potential to significantly contribute to the energy transition. The paper discusses the lack of knowledge in the market for the design of these grids, and presents a simulation approach to efficiently assemble hybrid networks and analyse them based on an electrical simulation. The authors also address the need to include process-specific characteristics in the planning and analysis of the electrical network, which is why common simulation tools for production processes are included in the approach. This allows economic, ecological, safety-relevant and technical aspects to be integrated into the planning process. The proposed concept is further discussed and planned for validation on the basis of a demonstrator currently under construction

A Transcriptomic Biomarker to Quantify Systemic Inflammation in Sepsis - A Prospective Multicenter Phase II Diagnostic Study.

International audienceDevelopment of a dysregulated immune response discriminates sepsis from uncomplicated infection. Currently used biomarkers fail to describe simultaneously occurring pro- and anti-inflammatory responses potentially amenable to therapy. Marker candidates were screened by microarray and, after transfer to a platform allowing point-of-care testing, validated in a confirmation set of 246 medical and surgical patients. We identified up-regulated pathways reflecting innate effector mechanisms, while down-regulated pathways related to adaptive lymphocyte functions. A panel of markers composed of three up- (Toll-like receptor 5; Protectin; Clusterin) and 4 down-regulated transcripts (Fibrinogen-like 2; Interleukin-7 receptor; Major histocompatibility complex class II, DP alpha1; Carboxypeptidase, vitellogenic-like) described the magnitude of immune alterations. The created gene expression score was significantly greater in patients with definite as well as with possible/probable infection than with no infection (median (Q25/Q75): 80 (60/101)) and 81 (58/97 vs. 49 (27/66), AUC-ROC=0.812 (95%-CI 0.755-0.869), p<0.0001). Down-regulated lymphocyte markers were associated with prognosis with good sensitivity but limited specificity. Quantifying systemic inflammation by assessment of both pro- and anti-inflammatory innate and adaptive immune responses provides a novel option to identify patients-at-risk and may facilitate immune interventions in sepsis