The Tension Between the Need and Exploitation of Migrant Workers: Using MSAWPA\u27s Legislative Intent to Find a Balanced Remedy

This Comment concludes that the recent Maine federal district cases represent an irreconcilable spike in a national and international trend to afford more protection to a vulnerable class whose resources are the object of urgent demand. However, the search for a proper remedial weight in the balance between migrant worker protection and the provision of competitive farm labor is not a new problem

Report and papers with guidelines on calibration of urban flood models

Computer modelling offers a sound scientific framework for well-structured analysis and management of urban drainage systems and flooding. Computer models are tools that are expected to simulate the behaviour of the modelled real system with a reasonable level of accuracy. Assurance of accurate representation of reality by a model is obtained through the model calibration. Model calibration is an essential step in modelling. This report present concepts and procedures for calibration and verification of urban flood models. The various stages in the calibration process are presented sequentially. For each stage, a discussion of general concepts is followed by descriptions of process elements. Finally, examples and experiences regarding application of the procedures in the CORFU Barcelona Case Study are presented. Calibration involves not only the adjustment of model parameters but also other activities such as model structural and functional validation, data checking and preparation, sensitivity analysis and model verification, that support and fortify the calibration process as a whole. The objective in calibration is the minimization of differences between model simulated results and observed measurements. This is normally achieved through a manual iterative parameter adjustment process but automatic calibration routines are also available, and combination parameter adjustment methods also exist. The focus of a model calibration exercise is not the same for all types of models. But regardless of the model type, good modelling practice should involve thorough model verification before application. A well-calibrated model can give the assurance that, at least for a range of tested conditions, the model behaves like the real system, and that the model is an accurate and reliable tool that may be used for further analysis. However, calibration could also reveal that the model cannot be calibrated and that the correctness of the model and its suitability as a tool for analysis and management of real-world systems could not be proven. The conceptualisation and simplification of real-world systems and associated processes in modelling inevitably lead to errors and uncertainty. Various modelling components introduce errors such as the input parameters, the model concept, scheme and corresponding model output, and the observed response measurements. Ultimately, the quality of the model as quantified by how much it deviates from reality is an aggregate of the errors that have been brought into it during the modelling process. Thus, it is important to identify the different error sources in a model and also account for and quantify them as part of the modelling.The work described in this publication was supported by the European Community’s Seventh Framework Programme through the grant to the budget of CORFU Collaborative Research on Flood Resilience in Urban Areas, Contract 244047

Archaeological Excavation of State Circle, Annapolis, Maryland

Other State Circle Site records include: 18AP50, Bordley-Randall Site (area 11), http://hdl.handle.net/1903/11016 ; 18AP55, Donaldson House (area 2), http://hdl.handle.net/1903/11019 ; 18AP61, Public Well Site (area 18), http://hdl.handle.net/1903/11020Archaeological excavations were conducted at State Circle in Annapolis during the fall and winter of 1989-1990 by "Archaeology in Annapolis", a cooperative program between the University of Maryland, College Park and the Historic Annapolis Foundation. Excavation was conducted as part of the undergrounding of public utility wires within State Circle, Francis Street, and School Street. The work was undertaken to satisfy the conditions of compliance as set forth in the Annotated Code of Maryland, Article 83b, sections 5-617 and 5-18. Twenty excavation area were selected for excavation within the project area. Areas were selected based on data gathered during historical background research. Areas were also selected in an attempt to gather information concerning the Baroque town plan designed in 1695 by Royal Governor Francis Nicholson. Three sites previously identified in the project area (18AP22, 18AP28, and 18AP50) were tested. Nine additional sites were discovered during excavation (18AP54, 18AP55, 18AP56, 18AP57, 18AP58, 18AP59, 18AP60, 18AP61, and 18AP62). At least one hand dug 3 ft by 5 ft unit per site was excavated. In all, a total of 23 units were excavated

Intra-aortic balloon pump inserted through the subclavian artery: A minimally invasive approach to mechanical support in the ambulatory end-stage heart failure patient

ObjectiveIntra-aortic balloon pumps are traditionally inserted through the femoral artery, limiting the patient's mobility. We used alternate approaches of intra-aortic balloon pump insertion to provide temporary and minimally invasive support for patients with decompensating, end-stage heart failure. The present study describes the outcomes with closed-chest, transthoracic intra-aortic balloon pumps by way of the subclavian artery.MethodsDuring a 3-year period, 20 patients underwent subclavian artery–intra-aortic balloon pump in the setting of end-stage heart failure. The balloon was inserted through a polytetrafluoroethylene graft sutured to the right subclavian artery in 19 patients (95%) and to the left subclavian artery in 1 patient (5%). The goal of support was to bridge to transplantation in 17 patients (85%) and bridge to recovery in 3 patients (15%). The primary outcome measure was death during subclavian artery–intra-aortic balloon pump support. The secondary outcomes included survival to the intended endpoint of bridge to transplantation/bridge to recovery, complications during subclavian artery–intra-aortic balloon pump support (eg, stroke, limb ischemia, brachial plexus injury, dissection, bleeding requiring reoperation, and device-related infection), emergent surgery for worsening heart failure, and ambulation during intra-aortic balloon pump support.ResultsThe duration of balloon support ranged from 3 to 48 days (mean, 17.3 ± 13.1 days). No patients died during subclavian artery–intra-aortic balloon pump support. Of the 20 patients, 14 (70%) were successfully bridged to transplant or left ventricular-assist device. Two patients (10%) required emergent left ventricular-assist device for worsening heart failure.ConclusionsAn intra-aortic balloon pump inserted through the subclavian artery is a simple, minimally invasive approach to mechanical support and is associated with limited morbidity and facilitates ambulation in patients with end-stage heart failure

Dabrafenib, alone or in combination with trametinib, in BRAF V600–mutated pediatric Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is a rare, heterogenous, neoplastic disorder primarily affecting children. BRAF mutations have been reported in >50% of patients with LCH. The selective BRAF inhibitor, dabrafenib, in combination with the MEK1/2 inhibitor, trametinib, has been approved in select BRAF V600–mutant solid tumors. Two open-label phase 1/2 studies were conducted in pediatric patients with BRAF V600–mutant, recurrent/refractory malignancies treated with dabrafenib monotherapy (CDRB436A2102; NCT01677741) or dabrafenib plus trametinib (CTMT212X2101; NCT02124772). The primary objectives of both studies were to determine safe and tolerable doses that achieve similar exposure to the approved doses for adults. Secondary objectives included safety, tolerability, and preliminary antitumor activity. Thirteen and 12 patients with BRAF V600–mutant LCH received dabrafenib monotherapy and in combination with trametinib, respectively. Investigator-assessed objective response rates per Histiocyte Society criteria were 76.9% (95% confidence interval [CI], 46.2-95.0) and 58.3% (95% CI, 27.7-84.8) in the monotherapy and combination studies, respectively. More than 90% of responses were ongoing at study completion. The most common treatment-related adverse events (AEs) were vomiting and increased blood creatinine with monotherapy and pyrexia, diarrhea, dry skin, decreased neutrophil count, and vomiting with combination therapy. Two patients each discontinued treatment with monotherapy and combination therapy because of AEs. Overall, dabrafenib monotherapy or in combination with trametinib demonstrated clinical efficacy and manageable toxicity in relapsed/refractory BRAF V600–mutant pediatric LCH, with most responses ongoing. Safety was consistent with that reported in other pediatric and adult conditions treated with dabrafenib plus trametinib

Renewable Energy Opportunities at Fort Sill, Oklahoma

This document provides an overview of renewable resource potential at Fort Sill, based primarily upon analysis of secondary data sources supplemented with limited on-site evaluations. This effort focuses on grid-connected generation of electricity from renewable energy sources and on ground source heat pumps for heating and cooling buildings. The effort was funded by the U.S. Army Installation Management Command (IMCOM) as follow-on to the 2005 Department of Defense (DoD) Renewables Assessment. The site visit to Fort Sill took place on June 10, 2010

Spectrum of statin hepatotoxicity: Experience of the drug‐induced liver injury network

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/108111/1/hep27157.pd