Statistical analysis summary.

<p>The tree represents the statistical analyses applied in the order in which they were performed. Distribution assumptions are indicated. Statistical packages are listed; where not specified, tests were conducted using R.</p

Effects of distribution assumptions on estimates.

<p>The means of the estimates for each variable obtained from Multiple Imputation (Panel A) or Bayesian modeling (Panel B) under a normal distribution assumption (assumption (vertical axis, transformed as indicated) or a Poisson distribution assumption (horizontal axis) were tested using Pearson’s linear regression. The slope estimate, R² and p are indicated in the insets.</p

Missingness map.

<p>Data missingness across all observation for infants with data available for both visit 1 and 2 (visit record). All infants had CD4⁺ T cell % assessments at each recorded visit (CD4; missingness = 0%). IL-7 ELISA assessments were missing for 20% of the recorded visits; flow cytometry assessments were missing for a median of 31% (min 31%, max 34%) of the recorded visits.</p

Data point availability.

<p>Subjects are grouped according to study visit (dark grey boxes; visit 1 = 1^st semester, visit 2 = 2^nd semester), and according to study group (light grey boxes; ART-Def = deferred treatment; ART-Early = early treatment). For each group, the number of tests available for analysis type is indicated (open boxes).</p

Selection of Charts for Review.

<p>Selection of Charts for Review.</p

Demographic, Clinical, Sputum, and TB& HIV Treatment Characteristics Among Survivors & Non-survivors of XDR-TB (n = 142).

*<p>not individually included in regression analysis.</p>**<p>p<0.05.</p>$<p>ttest.</p>§<p>Chi-square.</p>€<p>Kruskal-Wallis.</p

Regression Analysis Associated with Survival among XDR-TB patients with HIV-coinfection (n = 129).

<p>Regression Analysis Associated with Survival among XDR-TB patients with HIV-coinfection (n = 129).</p

Modifiable & Non-Modifiable Clinical Characteristics of XDR-TB Patients.

<p>Modifiable & Non-Modifiable Clinical Characteristics of XDR-TB Patients.</p