Second Order Perturbations of Flat Dust FLRW Universes with a Cosmological Constant

We summarize recent results concerning the evolution of second order perturbations in flat dust irrotational FLRW models with $\Lambda\ne 0$. We show that asymptotically these perturbations tend to constants in time, in agreement with the cosmic no-hair conjecture. We solve numerically the second order scalar perturbation equation, and very briefly discuss its all time behaviour and some possible implications for the structure formation.Comment: 6 pages, 1 figure. to be published in "Proceedings of the 5th Alexander Friedmann Seminar on Gravitation and Cosmology", Int. Journ. Mod. Phys. A (2002). Macros: ws-ijmpa.cls, ws-p9-75x6-50.cl

Correlation-Strength Driven Anderson Metal-Insulator Transition

The possibility of driving an Anderson metal-insulator transition in the presence of scale-free disorder by changing the correlation exponent is numerically investigated. We calculate the localization length for quasi-one-dimensional systems at fixed energy and fixed disorder strength using a standard transfer matrix method. From a finite-size scaling analysis we extract the critical correlation exponent and the critical exponent characterizing the phase transition.Comment: 3 pages; 2 figure

Laser transit anemometer and Pitot probe comparative measurements in a sharp cone boundary layer at Mach 4

Laser transit anemometer (LTA) measurements of a 7 degree sharp cone boundary layer were conducted in the Air Force/AEDC Supersonic Tunnel A Mach 4 flow field. These measurements are compared with Pitot probe measurements and tricone theory provided by AEDC staff. Measurements were made both in laminar and turbulent boundary layers of the model. Comparison of LTA measurements with theory showed agreement to better than 1 percent for the laminar boundary layer cases. This level of agreement was obtained after small position corrections, 0.01 to 0.6 mm, were applied to the experimental data sets. Pitot probe data when compared with theory also showed small positioning errors. The Pitot data value was also limited due to probe interference with the flow near the model. The LTA turbulent boundary layer data indicated a power law dependence of 6.3 to 6.9. The LTA data was analyzed in the time (Tau) domain in which it was obtained and in the velocity domain. No significant differences were noted between Tau and velocity domain results except in one turbulent boundary layer case

Increased desmin expression in hindlimb muscles of aging rats

Abstract Background Aging skeletal muscle frequently exhibits a reduction in force produced per unit muscle tissue, variously termed muscle quality, specific tension or dynapenia. Muscles from animals in which desmin expression is reduced exhibit similar properties, raising the possibility that reduced desmin expression contributes to impaired force production in aging muscles. Methods We examined expression of desmin and synemin, both intermediate filament proteins, in the plantarflexor muscles of adult (6-8 months) and older (24 months) rats. We have previously reported age-related reductions in muscle quality and sarcoplasmic reticulum function in these animals. Results Significant effects of age and muscle were found for the expression of desmin (P= 0.040 and <0.001 respectively), but not synemin. Desmin expression was increased in the aging muscles, with the greatest changes observed in the gastrocnemius muscles. Muscle quality, but not muscle mass, was reduced in the aging plantarflexor muscles. Conclusions Loss of desmin does not account for reduced force production in aging muscles. The potential effects of the age-related increase in desmin on muscle function remain unclear, but may include dissipation of contractile force

Perturbations of a Universe Filled with Dust and Radiation

A first-order perturbation approach to $k=0$ Friedmann cosmologies filled with dust and radiation is developed. Adopting the coordinate gauge comoving with the perturbed matter, and neglecting the vorticity of the radiation, a pair of coupled equations is obtained for the trace $h$ of the metric perturbations and for the velocity potential $v$. A power series solution with upwards cutoff exists such that the leading terms for large values of the dimensionless time $\xi$ agree with the relatively growing terms of the dust solution of Sachs and Wolfe.Comment: 9 pp, typeset in late

Volume Expansion of Swiss-Cheese Universe

In order to investigate the effect of inhomogeneities on the volume expansion of the universe, we study modified Swiss-Cheese universe model. Since this model is an exact solution of Einstein equations, we can get an insight into non-linear dynamics of inhomogeneous universe from it. We find that inhomogeneities make the volume expansion slower than that of the background Einstein-de Sitter universe when those can be regarded as small fluctuations in the background universe. This result is consistent with the previous studies based on the second order perturbation analysis. On the other hand, if the inhomogeneities can not be treated as small perturbations, the volume expansion of the universe depends on the type of fluctuations. Although the volume expansion rate approaches to the background value asymptotically, the volume itself can be finally arbitrarily smaller than the background one and can be larger than that of the background but there is an upper bound on it.Comment: 22 pages, 7 figures, to be submitted to Phys. Rev.

Epidermal Growth Factor–PEG Functionalized PAMAM-Pentaethylenehexamine Dendron for Targeted Gene Delivery Produced by Click Chemistry

Aim of this study was the site-specific conjugation of an epidermal growth factor (EGF)-polyethylene glycol (PEG) chain by click chemistry onto a poly(amido amine) (PAMAM) dendron, as a key step toward defined multifunctional carriers for targeted gene delivery. For this purpose, at first propargyl amine cored PAMAM dendrons with ester ends were synthesized. The chain terminal ester groups were then modified by oligoamines with different secondary amino densities. The oligoamine-modified PAMAM dendrons were well biocompatible, as demonstrated in cytotoxicity assays. Among the different oligoamine-modified dendrons, PAMAM-pentaethylenehexamine (PEHA) dendron polyplexes displayed the best gene transfer ability. Conjugation of PAMAM-PEHA dendron with PEG spacer was conducted via click reaction, which was performed before amidation with PEHA. The resultant PEG-PAMAM-PEHA copolymer was then coupled with EGF ligand. pDNA transfections in HuH-7 hepatocellular carcinoma cells showed a 10-fold higher efficiency with the polyplexes containing conjugated EGF as compared to the ligand-free ones, demonstrating the concept of ligand targeting. Overall gene transfer efficiencies, however, were moderate, suggesting that additional measures for overcoming subsequent intracellular bottlenecks in delivery have to be taken

Big data and data repurposing – using existing data to answer new questions in vascular dementia research

Introduction: Traditional approaches to clinical research have, as yet, failed to provide effective treatments for vascular dementia (VaD). Novel approaches to collation and synthesis of data may allow for time and cost efficient hypothesis generating and testing. These approaches may have particular utility in helping us understand and treat a complex condition such as VaD. Methods: We present an overview of new uses for existing data to progress VaD research. The overview is the result of consultation with various stakeholders, focused literature review and learning from the group’s experience of successful approaches to data repurposing. In particular, we benefitted from the expert discussion and input of delegates at the 9th International Congress on Vascular Dementia (Ljubljana, 16-18th October 2015). Results: We agreed on key areas that could be of relevance to VaD research: systematic review of existing studies; individual patient level analyses of existing trials and cohorts and linking electronic health record data to other datasets. We illustrated each theme with a case-study of an existing project that has utilised this approach. Conclusions: There are many opportunities for the VaD research community to make better use of existing data. The volume of potentially available data is increasing and the opportunities for using these resources to progress the VaD research agenda are exciting. Of course, these approaches come with inherent limitations and biases, as bigger datasets are not necessarily better datasets and maintaining rigour and critical analysis will be key to optimising data use