Anti-microbial Use in Animals: How to Assess the Trade-offs

Antimicrobials are widely used in preventive and curative medicine in animals. Benefits from curative use are clear – it allows sick animals to be healthy with a gain in human welfare. The case for preventive use of antimicrobials is less clear cut with debates on the value of antimicrobials as growth promoters in the intensive livestock industries. The possible benefits from the use of antimicrobials need to be balanced against their cost and the increased risk of emergence of resistance due to their use in animals. The study examines the importance of animals in society and how the role and management of animals is changing including the use of antimicrobials. It proposes an economic framework to assess the trade-offs of anti-microbial use and examines the current level of data collection and analysis of these trade-offs. An exploratory review identifies a number of weaknesses. Rarely are we consistent in the frameworks applied to the economic assessment anti-microbial use in animals, which may well be due to gaps in data or the prejudices of the analysts. There is a need for more careful data collection that would allow information on (i) which species and production systems antimicrobials are used in, (ii) what active substance of antimicrobials and the application method and (iii) what dosage rates. The species need to include companion animals as well as the farmed animals as it is still not known how important direct versus indirect spread of resistance to humans is. In addition, research is needed on pricing antimicrobials used in animals to ensure that prices reflect production and marketing costs, the fixed costs of anti-microbial development and the externalities of resistance emergence. Overall, much work is needed to provide greater guidance to policy, and such work should be informed by rigorous data collection and analysis systems

Social Context and Voting over Taxes: Evidence from a Referendum in Alabama

We investigate the impact of racial diversity and segregation on white voter support for a comprehensive, progressive tax reform. We focus on a 2003 referendum held in Alabama, which if approved would have raised substantial additional revenues for public education and at the same time greatly increased the progressivity of the tax system. We use King's (1997) method of ecological inference to obtain estimates of white and black support for the referendum proposal, and we then attempt to explain the variance across counties in white voter support. We find that the degree of racial segregation, rather than the proportion of blacks in a given county, is most critical in predicting support for the referendum among whites at the county level. Working Paper 06-0

Patients with ALS show highly correlated progression rates in left and right limb muscles.

ObjectiveAmyotrophic lateral sclerosis (ALS) progresses at different rates between patients, making clinical trial design difficult and dependent on large cohorts of patients. Currently, there are few data showing whether the left and right limbs progress at the same or different rates. This study addresses rates of decline in specific muscle groups of patients with ALS and assesses whether there is a relationship between left and right muscles in the same patient, regardless of overall progression.MethodsA large cohort of patients was used to assess decline in muscle strength in right and left limbs over time using 2 different methods: The Tufts Quantitative Neuromuscular Exam and Accurate Test of Limb Isometric Strength protocol. Then advanced linear regression statistical methods were applied to assess progression rates in each limb.ResultsThis report shows that linearized progression models can predict general slopes of decline with good accuracy. Critically, the data demonstrate that while overall decline is variable, there is a high degree of correlation between left and right muscle decline in ALS. This implies that irrespective of which muscle starts declining soonest or latest, their rates of decline following onset are more consistent.ConclusionsFirst, this study demonstrates a high degree of power when using unilateral treatment approaches to detect a slowing in disease progression in smaller groups of patients, thus allowing for paired statistical tests. These findings will be useful in transplantation trials that use muscle decline to track disease progression in ALS. Second, these findings discuss methods, such as tactical selection of muscle groups, which can improve the power efficiency of all ALS clinical trials

An examination of the hydrological system of a sand dam during the dry season leading to water balances

To address water scarcity in semi-arid regions, rainfall and runoff need to be captured and stored locally before they are lost to the sea. This can be done using a sand dam which consists of a reinforced wall constructed during the dry season across a seasonal riverbed. However it is unclear whether their main utility is to store water in the sand that is also trapped behind them, or to facilitate aquifer recharge. This paper aims to answer this question by the calculation of a water balance in three sand dams in Kenya to quantify the amount of water transferred between the sand dam and the surrounding aquifer system. The components of the water balance were derived from extensive field monitoring. Water level monitoring in piezometers installed along the length of the sand deposits enabled calculation of the hydraulic gradient and hence the lateral flow between the different reaches of the sand dam. In one sand dam water was gained consistently through the dry season, in one it was lost, and in the third it was lost almost all the time except for the early dry season in the upper part of the trapped sand. In conclusion sand dams should not be treated as isolated water storage structures