Renal Artery Stenosis and Ipsilateral Renal Cell Carcinoma: Description of an In Situ Partial Nephrectomy and Splenorenal Arterial Bypass

A case of a renal artery stenosis and ipsilateral renal cell carcinoma with long term results is reported. A 65-year-old man with renovascular hypertension, renal insufficiency, and nephrotic range proteinuria presented with an incidental renal cell carcinoma. Concomitant in situ left partial nephrectomy and splenorenal arterial bypass was achieved. The patient is doing well without evidence of malignancy, stable renal function, markedly improved proteinuria and stable blood pressure more than three years later. The techniques of this procedure are detailed and underscore the possibility of successful removal of a renal cell carcinoma with preservation of renal function despite renal artery stenosis

Probing Color Response - Wakes in a Color Plasma

The wake induced in a hot QCD medium by a high momentum parton (jet precursor) is calculated in the framework of linear response theory. Two different scenarios are discussed: a weakly coupled quark gluon plasma (pQGP) as described by hard-thermal loop (HTL) perturbation theory and a strongly cupled QGP (sQGP) with the properties of a quantum liquid. In the latter case the wake could exhibit a pronounced Mach cone structure. This physical mechanism could be important for the understanding of preliminary data from the PHENIX and STAR experiments at RHIC on the angular distribution of low-pt secondaries stemming from the away-side jet which indicate maxima at $\Delta\phi=\pi \pm 1.1$.Comment: Prepared for: Workshop on Correlations and Fluctuations in Relativistic Nuclear Collisions, MIT, Cambridge, Massachusetts, USA, 21-23 April 200

Hard and soft probe - medium interactions in a 3D hydro+micro approach at RHIC

We utilize a 3D hybrid hydro+micro model for a comprehensive and consistent description of soft and hard particle production in ultra-relativistic heavy-ion collisions at RHIC. In the soft sector we focus on the dynamics of (multi-)strange baryons, where a clear strangeness dependence of their collision rates and freeze-out is observed. In the hard sector we study the radiative energy loss of hard partons in a soft medium in the multiple soft scattering approximation. While the nuclear suppression factor $R_{AA}$ does not reflect the high quality of the medium description (except in a reduced systematic uncertainty in extracting the quenching power of the medium), the hydrodynamical model also allows to study different centralities and in particular the angular variation of $R_{AA}$ with respect to the reaction plane, allowing for a controlled variation of the in-medium path-length.Comment: 5 pages, 4 figures, Quark Matter 2006 proceedings, to appear in Journal of Physics

Molecular and biochemical alterations in tubular epithelial cells of patients with isolated methylmalonic aciduria

Methylmalonic acidurias (MMAurias) are a group of inherited disorders in the catabolism of branched-chain amino acids, odd-chain fatty acids and cholesterol caused by complete or partial deficiency of methylmalonyl-CoA mutase (mut0 and mut- subtype respectively) and by defects in the metabolism of its cofactor 5′-deoxyadenosylcobalamin (cblA, cblB or cblD variant 2 type). A long-term complication found in patients with mut0 and cblB variant is chronic tubulointerstitial nephritis. The underlying pathomechanism has remained unknown. We established an in vitro model of tubular epithelial cells from patient urine (hTEC; 9 controls, 5 mut0, 1 cblB). In all human tubular epithelial cell (hTEC) lines we found specific tubular markers (AQP1, UMOD, AQP2). Patient cells showed disturbance of energy metabolism in glycolysis, mitochondrial respiratory chain and Krebs cycle in concert with increased reactive oxygen species (ROS) formation. Electron micrographs indicated increased autophagosome production and endoplasmic reticulum stress, which was supported by positive acridine orange staining and elevated levels of LC3 II, P62 and pIRE1. Screening mTOR signaling revealed a release of inhibition of autophagy. Patient hTEC produced and secreted elevated amounts of the pro-inflammatory cytokine IL8, which was highly correlated with the acridine orange staining. Summarizing, hTEC of MMAuria patients are characterized by disturbed energy metabolism and ROS production that lead to increased autophagy and IL8 secretio

Systematic Comparison of Jet Energy-Loss Schemes in a 3D hydrodynamic medium

We utilize a 3D hydrodynamic model to provide the medium evolution for a systematic comparison of jet energy-loss calculations in the BDMPS/ASW, HT and AMY approaches. We find that the parameters of all three calculations can be adjusted to provide a good description of inclusive data on $R_{AA}$ versus transverse momentum. However, we do observe slight differences in their predictions for the azimuthal angular dependence of $R_{AA}$ vs. $p_T$. We also note that the value of the transport coefficient $\hat{q}$ needed in the three approaches to describe the data differs significantly.Comment: 4 pages, 4 figures, proceedings of Quark Matter 200