Curie: Constraining Solar System Bombardment Using In Situ Radiometric Dating

The Curie mission would constrain the existence of the putative cataclysm by determining the age of samples directly sourced from the impact melt sheet of a major pre-Imbrium lunar basin. The measurements would also enable further understanding of lunar evolution by characterizing new lunar lithologies far from the Apollo and Luna landing sites, including the very low-Ti basalts in Mare Crisium and potential olivine rich lithologies in the margins of both Mare Nectaris and Mars Crisium. Equipped with a mass spectrometer and a LIBS, Curie would also be well-placed to survey volatile components of the lunar regolith, including surface-bound hydrogen

Moons Are Planets: Scientific Usefulness Versus Cultural Teleology in the Taxonomy of Planetary Science

We argue that taxonomical concept development is vital for planetary science as in all branches of science, but its importance has been obscured by unique historical developments. The literature shows that the concept of planet developed by scientists during the Copernican Revolution was theory-laden and pragmatic for science. It included both primaries and satellites as planets due to their common intrinsic, geological characteristics. About two centuries later the non-scientific public had just adopted heliocentrism and was motivated to preserve elements of geocentrism including teleology and the assumptions of astrology. This motivated development of a folk concept of planet that contradicted the scientific view. The folk taxonomy was based on what an object orbits, making satellites out to be non-planets and ignoring most asteroids. Astronomers continued to keep primaries and moons classed together as planets and continued teaching that taxonomy until the 1920s. The astronomical community lost interest in planets ca. 1910 to 1955 and during that period complacently accepted the folk concept. Enough time has now elapsed so that modern astronomers forgot this history and rewrote it to claim that the folk taxonomy is the one that was created by the Copernican scientists. Starting ca. 1960 when spacecraft missions were developed to send back detailed new data, there was an explosion of publishing about planets including the satellites, leading to revival of the Copernican planet concept. We present evidence that taxonomical alignment with geological complexity is the most useful scientific taxonomy for planets. It is this complexity of both primary and secondary planets that is a key part of the chain of origins for life in the cosmos.Comment: 68 pages, 16 figures. For supplemental data files, see https://www.philipmetzger.com/moons_are_planets

Safety and efficacy of an oxycodone vaccine: Addressing some of the unique considerations posed by opioid abuse

Among vaccines aimed at treating substance use disorders, those targeting opioids present several unique medication development challenges. 1) Opioid overdose is a common complication of abuse, so it is desirable for an opioid vaccine to block the toxic as well as the addictive effects of opioids. 2) It is important that an opioid vaccine not interfere with the action of opioid antagonists used to reverse opioid overdose or treat addiction. 3) Some opioids are immunosuppressive and chronic ongoing opioid use could interfere with vaccine immunogenicity. 4) Although antibody-bound oxycodone is unable to enter the brain because of its size, it might still be able to activate peripheral opioid receptors. To assess vaccine impact on opioid toxicity, rats vaccinated with oxycodone conjugated to keyhole limpet hemocyanin subunit dimer (OXY-dKLH) adsorbed to alum or controls vaccinated with dKLH were compared with regard to oxycodone-induced hotplate analgesia and oxycodone-induced respiratory depression and bradycardia. Vaccination shifted the dose-response curves to the right, representing protection, for each of these endpoints. Naloxone was equally effective in both OXY-dKLH and control groups, providing complete and rapid reversal of respiratory depression. The administration of a long-acting naltrexone formulation during vaccination did not impair vaccine immunogenicity in mice. Similarly, serum anti-oxycodone antibody titers were not altered by continuous morphine infusion during vaccination compared to opioid-naïve controls. Competitive ELISA assay showed negligible or low affinity of immune antiserum for endogenous opioids or opioid antagonists. In vitro receptor binding assays showed that antibody-bound oxycodone does not activate mu opioid receptors. These data support further study of OXY-dKLH as a potential treatment for oxycodone abuse and suggest that vaccination might also reduce the severity of oxycodone overdose

Cooperation between the United States Department of Energy National Laboratories and Mayak Production Association for enhancements to material protection control and accounting systems

The Agreement Between the Department of Defense of the United States and The Ministry of the Russian Federation for Atomic Energy (MINATOM) Concerning Control, Accounting, and Physical Protection of Nuclear Material, as well as a subsequent amendment to that agreement and a joint statement signed by the Department of Energy (DOE) and MINATOM, resulted in the selection of the Mayak Production Association (MPA) as one of the Russian enterprises that would participate with DOE Laboratories in expanded cooperation aimed at enhancing Material protection, Control and Accounting (MPC&A) systems in both countries. This paper describes the nature and scope of the expanded cooperation involving MPA and six DOE laboratories at an operating civilian, spent-nuclear-fuel reprocessing plant designated RT-1. RT-1 produces, among other materials, reactor-grade plutonium dioxide, a direct-use material that is stored within the boundaries of this plant. Initial efforts at expanded cooperation will focus on enhancements to the existing MPC&A systems at MPA`s RT-1 plant

Pluto's Far Side

The New Horizons spacecraft provided near-global observations of Pluto that far exceed the resolution of Earth-based datasets. However, most previous Pluto New Horizons analyses focused on the New Horizons encounter hemisphere (i.e., the anti-Charon hemisphere containing Sputnik Planitia). In this work, we summarize and interpret data on Pluto's “far side” (i.e., its non-encounter or alternatively, its sub-Charon hemisphere), providing the first integrated New Horizons overview of Pluto's far side terrains. We find strong evidence for widespread bladed (i.e., aligned CH₄-mountain) deposits, evidence for an impact crater about as large as any on the “near side” hemisphere, evidence for complex lineations approximately antipodal to Sputnik Planitia that may be causally related, evidence that the far side maculae (i.e., equatorial dark regions) are smaller and more structured than Pluto's encounter hemisphere maculae, and more

Mineralogy of the Lunar Crust in Spatial Context: First Results from the Moon Mineralogy Mapper (M3)

India's Chandrayaan-1 successfully launched October 22, 2008 and went into lunar orbit a few weeks later. Commissioning of instruments began in late November and was near complete by the end of the year. Initial data for NASA's Moon Mineralogy Mapper (M3) were acquired across the Orientale Basin and the science results are discussed here. M 3 image-cube data provide mineralogy of the surface in geologic context. A major new result is that the existence and distribution of massive amounts of anorthosite as a continuous stratigraphic crustal layer is now irrefutable

Identification of a New Spinel-Rich Lunar Rock Type by the Moon Mineralogy Mapper (M (sup 3))

The canonical characterization of the lunar crust is based principally on available Apollo, Luna, and meteorite samples. The crust is described as an anorthosite-rich cumulate produced by the lunar magma ocean that has been infused with a mix of Mgsuite components. These have been mixed and redistributed during the late heavy bombardment and basin forming events. We report a new rock-type detected on the farside of the Moon by the Moon Mineralogy Mapper (M3) on Chandrayaan-1 that does not easily fit with current crustal evolution models. The rock-type is dominated by Mg-spinel with no detectible pyroxene or olivine present (<5%). It occurs along the western inner ring of Moscoviense Basin as one of several discrete areas that exhibit unusual compositions relative to their surroundings but without morphological evidence for separate processes leading to exposure

Cryovolcanic flooding in Viking Terra on Pluto

A prominent fossa trough (Uncama Fossa) and adjacent 28-km diameter impact crater (Hardie) in Pluto's Viking Terra, as seen in the high-resolution images from the New Horizons spacecraft, show morphological evidence of in-filling with a material of uniform texture and red-brown color. A linear fissure parallel to the trough may be the source of a fountaining event yielding a cryoclastic deposit having the same composition and color properties as is found in the trough and crater. Spectral maps of this region with the New Horizons LEISA instrument reveal the spectral signature of H₂O ice in these structures and in distributed patches in the adjacent terrain in Viking Terra. A detailed statistical analysis of the spectral maps shows that the colored H₂O ice filling material also carries the 2.2-μm signature of an ammoniated component that may be an ammonia hydrate (NH₃nH₂O) or an ammoniated salt. This paper advances the view that the crater and fossa trough have been flooded by a cryolava debouched from Pluto's interior along fault lines in the trough and in the floor of the impact crater. The now frozen cryolava consisted of liquid H₂O infused with the red-brown pigment presumed to be a tholin, and one or more ammoniated compounds. Although the abundances of the pigment and ammoniated compounds entrained in, or possibly covering, the H₂O ice are unknown, the strong spectral bands of the H₂O ice are clearly visible. In consideration of the factors in Pluto's space environment that are known to destroy ammonia and ammonia-water mixtures, the age of the exposure is of order ≤10⁹ years. Ammoniated salts may be more robust, and laboratory investigations of these compounds are needed