Análisis de referencias culturales y estrategias aplicada en la localización de videojuegos del chino al español: el caso de Genshin Impact

En este estudio, se centra en las estrategias utilizadas para adaptar las referencias culturales en la localización del videojuego Genshin Impact al español, con especial énfasis en los elementos gastronómicos de las regiones de Liyue e Inazuma. La elección de este tema se debe a la popularidad de Genshin Impact en España y América Latina y al vacío de estudios centrados en la localización de videojuegos chinos al español. Este estudio tiene como objetivo principal analizar las referencias culturales y las estrategias aplicadas para su adaptación en el proceso de localización de videojuegos chino-español, en el caso de Genshin Impact. Los objetivos específicos del estudio son identificar las referencias culturales en Genshin Impact, analizar las estrategias utilizadas en su localización y evaluar su efectividad. Con base en los resultados de este análisis, se proporciona una comprensión más profunda de los desafíos y soluciones en la localización de videojuegos chinos, y proponer recomendaciones prácticas para mejorar la calidad de la localización de referencias culturales en videojuegos chino-español.Universidad de Granada. Grado en Traducción e Interpretació

Biomechanical study of two-level oblique lumbar interbody fusion with different types of lateral instrumentation: a finite element analysis

ObjectiveThe aim of this study was to verify the biomechanical properties of a newly designed angulated lateral plate (mini-LP) suited for two-level oblique lumbar interbody fusion (OLIF). The mini-LP is placed through the lateral ante-psoas surgical corridor, which reduces the operative time and complications associated with prolonged anesthesia and placement in the prone position.MethodsA three-dimensional nonlinear finite element (FE) model of an intact L1–L5 lumbar spine was constructed and validated. The intact model was modified to generate a two-level OLIF surgery model augmented with three types of lateral fixation (stand-alone, SA; lateral rod screw, LRS; miniature lateral plate, mini-LP); the operative segments were L2–L3 and L3–L4. By applying a 500 N follower load and 7.5 Nm directional moment (flexion-extension, lateral bending, and axial rotation), all models were used to simulate human spine movement. Then, we extracted the range of motion (ROM), peak contact force of the bony endplate (PCFBE), peak equivalent stress of the cage (PESC), peak equivalent stress of fixation (PESF), and stress contour plots.ResultsWhen compared with the intact model, the SA model achieved the least reduction in ROM to surgical segments in all motions. The ROM of the mini-LP model was slightly smaller than that of the LRS model. There were no significant differences in surgical segments (L1–L2, L4–L5) between all surgical models and the intact model. The PCFBE and PESC of the LRS and the mini-LP fixation models were lower than those of the SA model. However, the differences in PCFBE or PESC between the LRS- and mini-LP-based models were not significant. The fixation stress of the LRS- and mini-LP-based models was significantly lower than the yield strength under all loading conditions. In addition, the variances in the PESF in the LRS- and mini-LP-based models were not obvious.ConclusionOur biomechanical FE analysis indicated that LRS or mini-LP fixation can both provide adequate biomechanical stability for two-level OLIF through a single incision. The newly designed mini-LP model seemed to be superior in installation convenience, and equally good outcomes were achieved with both LRS and mini-LP for two-level OLIF

Towards a global partnership model in interprofessional education for cross-sector problem-solving

Objectives A partnership model in interprofessional education (IPE) is important in promoting a sense of global citizenship while preparing students for cross-sector problem-solving. However, the literature remains scant in providing useful guidance for the development of an IPE programme co-implemented by external partners. In this pioneering study, we describe the processes of forging global partnerships in co-implementing IPE and evaluate the programme in light of the preliminary data available. Methods This study is generally quantitative. We collected data from a total of 747 health and social care students from four higher education institutions. We utilized a descriptive narrative format and a quantitative design to present our experiences of running IPE with external partners and performed independent t-tests and analysis of variance to examine pretest and posttest mean differences in students’ data. Results We identified factors in establishing a cross-institutional IPE programme. These factors include complementarity of expertise, mutual benefits, internet connectivity, interactivity of design, and time difference. We found significant pretest–posttest differences in students’ readiness for interprofessional learning (teamwork and collaboration, positive professional identity, roles, and responsibilities). We also found a significant decrease in students’ social interaction anxiety after the IPE simulation. Conclusions The narrative of our experiences described in this manuscript could be considered by higher education institutions seeking to forge meaningful external partnerships in their effort to establish interprofessional global health education

Soy Isoflavones Inhibit Both GPIb-IX Signaling and αIIbβ3 Outside-In Signaling via 14-3-3ζ in Platelet

Soy diet is thought to help prevent cardiovascular diseases in humans. Isoflavone, which is abundant in soybean and other legumes, has been reported to possess antiplatelet activity and potential antithrombotic effect. Our study aims to elucidate the potential target of soy isoflavone in platelet. The anti-thrombosis formation effect of genistein and daidzein was evaluated in ex vivo perfusion chamber model under low (300 s−1) and high (1800 s−1) shear forces. The effect of genistein and daidzein on platelet aggregation and spreading was evaluated with platelets from both wildtype and GPIbα deficient mice. The interaction of these soy isoflavone with 14-3-3ζ was detected by surface plasmon resonance (SPR) and co-immunoprecipitation, and the effect of αIIbβ3-mediated outside-in signaling transduction was evaluated by western blot. We found both genistein and daidzein showed inhibitory effect on thrombosis formation in perfusion chamber, especially under high shear force (1800 s−1). These soy isoflavone interact with 14-3-3ζ and inhibited both GPIb-IX and αIIbβ3-mediated platelet aggregation, integrin-mediated platelet spreading and outside-in signaling transduction. Our findings indicate that 14-3-3ζ is a novel target of genistein and daidzein. 14-3-3ζ, an adaptor protein that regulates both GPIb-IX and αIIbβ3-mediated platelet activation is involved in soy isoflavone mediated platelet inhibition

Study on the Electrochemical Reduction Reaction Process of Cr(Ⅲ) in ChCl - EG Deep Eutectic Solvent System

In order to explore the electrochemical reduction reaction process of trivalent chromium ions, ultraviolet visible spectrophotometry (UV - Vis), linear sweep voltammetry (LSV), cyclic voltammetry (CV) and other methods were used to study the existing forms of the coordination compounds at the initial reduction stage of Cr (Ⅲ) ions in choline chloride - ethylene glycol (ChCl - EG) deep eutectic solvent system, the electrochemical reduction reaction process of Cr (Ⅲ) ions, the apparent activation energy of the reduction process of Cr (Ⅲ) ions in the electrolyte and the control steps of the reduction process. Results showed that at the initial reduction stage of Cr (Ⅲ) in deep eutectic solvent, the coordination compounds of [Cr(H2O)3Cl3] and [Cr(H2O)2Cl4 ]- would be preferentially formed, and the [Cr(H2O)2Cl4]- was the main coordination compound. With the increase of the concentration of CrCl3·6H2O, the form of coordination compound had a tendency to partially convert from [Cr(H2O)2Cl4]- to [Cr(H2O)3Cl3], and through an analysis taking into account both this tendency and the dissociation energy, it could be found that the transformation of the coordination compound made the reduction of Cr3+→Cr2+ easier. The reduction of trivalent chromium ions in ChCl - EG deep eutectic solvent was a two - step process: Cr3+→Cr2+→Cr. In the first step, the apparent activation energy was in the range of 12～16 kJ/mol and controlled by the diffusion step. In the second step, the apparent activation energy was in the range of 16～40 kJ/mol and controlled by both electrochemical and diffusion steps

Global 30 meters spatiotemporal 3D urban expansion dataset from 1990 to 2010

Abstract Understanding the spatiotemporal dynamics of global 3D urban expansion over time is becoming increasingly crucial for achieving long-term development goals. In this study, we generated a global dataset of annual urban 3D expansion (1990–2010) using World Settlement Footprint 2015 data, GAIA data, and ALOS AW3D30 data with a three-step technical framework: (1) extracting the global constructed land to generate the research area, (2) neighborhood analysis to calculate the original normalized DSM and slope height of each pixel in the study area, and (3) slope correction for areas with a slope greater than 10° to improve the accuracy of estimated building heights. The cross-validation results indicate that our dataset is reliable in the United States(R2 = 0.821), Europe(R2 = 0.863), China(R2 = 0.796), and across the world(R2 = 0.811). As we know, this is the first 30-meter 3D urban expansion dataset across the globe, which can give unique information to understand and address the implications of urbanization on food security, biodiversity, climate change, and public well-being and health

Propofol inhibits colon cancer cell stemness and epithelial-mesenchymal transition by regulating SIRT1, Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways

Abstract Background Propofol is a common sedative-hypnotic drug used for general anesthesia. Recent studies have drawn attention to the antitumor effects of propofol, but the potential mechanism by which propofol suppresses colon cancer stemness and epithelial-mesenchymal transition (EMT) has not been fully elucidated. Methods For the in vitro experiments, we used propofol to treat LOVO and SW480 cells and Cell Counting Kit-8 (CCK-8) to detect proliferation. Self-renewal capacity, cell invasion and migration, flow cytometry analysis, qPCR and Western blotting were performed to detect the suppression of propofol to colon cancer cells and the underlying mechanism. Tumorigenicity and immunohistochemistry experiments were performed to confirm the role of propofol in vivo. Result We observed that propofol could suppressed stem cell-like characteristics and EMT-related behaviors, including self-renewal capacity, cell invasion and migration in colon cancer cells, and even suppressed tumorigenicity in vivo. Furthermore, investigations of the underlying mechanism revealed that propofol treatment downregulated SIRT1. SIRT1 overexpression or knockdown affected the stemness and EMT of colon cancer cells. Additionally, propofol reversed stemness and EMT in cells with overexpressing SIRT1 and subsequently inhibited the Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways. Wnt/β-catenin pathway inhibitor and PI3K/AKT/mTOR pathway inhibitor blocked the propofol-induced reduction of sphere-formation and cell invasion-migration. Conclusion Propofol inhibits LOVO and SW480 cell stemness and EMT by regulating SIRT1 and the Wnt/β-catenin and PI3K/AKT/mTOR signaling pathways. Our findings indicate that propofol inhibits SIRT1 in cancer and is advantageous in colon cancer surgical treatment of patients with high SIRT1 expression

Table_1_Transcriptomic analysis and experiments revealed that remimazolam promotes proliferation and G1/S transition in HCT8 cells.docx

BackgroundRemimazolam is a new ultrashort-acting benzodiazepine for sedation and anesthesia. The effects of remimazolam and the mechanism by which it functions in cancer cells have not been determined. This research aimed to explore the mechanism of remimazolam action in colon cancer treatment, using bioinformatics analysis and in vitro experiments.MethodsCell cycle progression, colony formation, self-renewal capacity, and apoptosis detection were performed in HCT8 cells treated with or without remimazolam. Transcriptome sequencing, Gene Ontology, Kyoto Encyclopedia of Genes and Genome, Protein–Protein Interaction, Gene Set Enrichment Analysis, Western blotting, and qPCR were performed to investigate the mechanism of action of remimazolam in HCT8 colon cancer cells.ResultsRemimazolam promoted proliferation and cell-cycle progression of HCT8 cells. After remimazolam treatment, a total of 1,096 differentially expressed genes (DEGs) were identified: 673 genes were downregulated, and 423 genes were upregulated. The DEGs were enriched mainly in “DNA replication“, “cell cycle”, and “G1/S transition” related pathways. There were 15 DEGs verified by qPCR, and representative biomarkers were detected by Western Bloting. The remimazolam-mediated promotion of cell proliferation and cell cycle was reversed by G1T28, a CDK4/6 inhibitor.ConclusionRemimazolam promoted cell-cycle progression and proliferation in HCT8 colon cancer cells, indicating that the long-term use of remimazolam has potential adverse effects in the anesthesia of patients with colon cancer.</p

Insights into the effect of metal ratio on cooperative redox enhancement effects over au- and pd-mediated alcohol oxidation

The aerobic oxidation of alcohols and aldehydes over supported heterogeneous catalysts can be considered as comprising two complementary and linked processes: dehydrogenation and oxygen reduction. Significant rate enhancements can be observed when these processes are catalyzed by independent active sites, coupled by electron transport between the two catalysts. This effect, termed cooperative redox enhancement (CORE), could significantly influence how researchers approach catalyst design, but a greater understanding of the factors which influence it is required. Herein, we demonstrate that the Au/Pd ratio used in physical mixtures of monometallic catalysts and phase-separated Au and Pd bimetallic catalysts dramatically influences the degree to which CORE effects can promote alcohol oxidation. Perhaps more interestingly, the roles of Au and Pd in this coupled system are determined to be interchangeable. Preliminarily, we hypothesize that this is attributed to the relative rates of the coupled reactions and demonstrate how physical properties can influence this. This deeper understanding of the factors which influence CORE is an important development in bimetallic catalysis