A Cross-Species Study of Gesture and Its Role in Symbolic Development: Implications for the Gestural Theory of Language Evolution

Using a naturalistic video database, we examined whether gestures scaffold the symbolic development of a language-enculturated chimpanzee, a language-enculturated bonobo, and a human child during the second year of life. These three species constitute a complete clade: species possessing a common immediate ancestor. A basic finding was the functional and formal similarity of many gestures between chimpanzee, bonobo, and human child. The child\u27s symbols were spoken words; the apes\u27 symbols were lexigrams - non-iconic visual signifiers. A developmental pattern in which gestural representation of a referent preceded symbolic representation of the same referent appeared in all three species (but was statistically significant only for the child). Nonetheless, across species, the ratio of symbol to gesture increased significantly with age. But even though their symbol production increased, the apes continued to communicate more frequently by gesture than by symbol. In contrast, by 15-18 months of age, the child used symbols more frequently than gestures. This ontogenetic sequence from gesture to symbol, present across the clade but more pronounced in child than ape, provides support for the role of gesture in language evolution. In all three species, the overwhelming majority of gestures were communicative (i.e., paired with eye contact, vocalization, and/or persistence). However, vocalization was rare for the apes, but accompanied the majority of the child\u27s communicative gestures. This species difference suggests the co-evolution of speech and gesture after the evolutionary divergence of the hominid line. Multimodal expressions of communicative intent (e.g., vocalization plus persistence) were normative for the child, but less common for the apes. This species difference suggests that multimodal expression of communicative intent was also strengthened after hominids diverged from apes

Construction of a bacterial autoinducer detection system in mammalian cells

Quorum sensing (QS) is a cell density-dependent signaling system used by bacteria to coordinate gene expression within a population. QS systems in Gram negative bacteria consist of transcription factors of the LuxR family and their acyl homoserine lactone (AHL) ligands. We describe here a method for examining QS signaling systems in mammalian cells that uses engineered LuxR-type proteins from the opportunistic pathogen, Pseudomonas aeruginosa, which can function as AHL-dependent transcription factors. The engineered proteins respond to their cognate ligands and display sequence specific DNA binding properties. This system has several potential biotechnological and biological applications. It may be used to characterize any LuxR-type protein, screen animal and plant cell extracts or exudates for compounds that mimic or interfere with AHL signaling or to screen different cell types for AHL inactivating activities

Social evolution in micro-organisms and a Trojan horse approach to medical intervention strategies

Medical science is typically pitted against the evolutionary forces acting upon infective populations of bacteria. As an alternative strategy, we could exploit our growing understanding of population dynamics of social traits in bacteria to help treat bacterial disease. In particular, population dynamics of social traits could be exploited to introduce less virulent strains of bacteria, or medically beneficial alleles into infective populations. We discuss how bacterial strains adopting different social strategies can invade a population of cooperative wild-type, considering public good cheats, cheats carrying medically beneficial alleles (Trojan horses) and cheats carrying allelopathic traits (anti-competitor chemical bacteriocins or temperate bacteriophage viruses). We suggest that exploitation of the ability of cheats to invade cooperative, wild-type populations is a potential new strategy for treating bacterial disease

Chronos and KAIROS: MOSFIRE observations of post-starburst galaxies in z ∼ 1 clusters and groups

We present an exploration of ∼500 spectroscopically confirmed galaxies in and around two large-scale structures (LSSs) at z ∼ 1 drawn from the Observations of Redshift Evolution in Large Scale Environments survey, an ongoing, wide-field photometric and spectroscopic campaign targeting a large ensemble of LSSs at 0.6 < z < 1.3. A sub-sample of these galaxies (∼150) was targeted for the initial phase of a near-infrared MOSFIRE spectroscopic campaign investigating the differences in selections of galaxies that had recently ended a burst of star formation and/or had rapidly quenched (i.e. post-starburst/K+A galaxies). Selection with MOSFIRE utilizing the H α and [N II] emission features resulted in a post-starburst sample more than double that selected by traditional z ∼ 1 (observed-frame optical) methods even after the removal of the relatively large fraction of dusty starburst galaxies selected through traditional methods. While the traditional post-starburst fraction increased with increasing global density, the MOSFIRE-selected post-starburst fraction was found to be constant across field, group, and cluster environments. However, this fraction computed relative to the number of star-forming galaxies was observed to elevate in the cluster environment. Post-starbursts selected with MOSFIRE exhibited moderately strong [O II] emission originating from activity other than star formation. Such galaxies, termed K+A with ImposteR [O II]-derived Star formation (KAIROS) galaxies, were found to be younger than and likely undergoing feedback absent or diminished in their optically selected counterparts. A comparison between the environments of the two types of post-starbursts suggested a picture in which the evolution of a post-starburst galaxy is considerably different in cluster environments than in the more rarefied environments of a group or the field

Suppressed star formation by a merging cluster system

We examine the effects of an impending cluster merger on galaxies in the large-scale structure (LSS) RX J0910 at z =1.105. Using multiwavelength data, including 102 spectral members drawn from the Observations of Redshift Evolution in Large Scale Environments (ORELSE) survey and precise photometric redshifts, we calculate star formation rates and map the specific star formation rate density of the LSS galaxies. These analyses along with an investigation of the colour–magnitude properties of LSS galaxies indicate lower levels of star formation activity in the region between the merging clusters relative to the outskirts of the system. We suggest that gravitational tidal forces due to the potential of the merging haloes may be the physical mechanism responsible for the observed suppression of star formation in galaxies caught between the merging clusters

X-ray-emitting active galactic nuclei from z = 0.6 to 1.3 in the intermediate- and high-density environments of the ORELSE survey

We studied active galactic nucleus (AGN) activity in 12 large-scale structures (LSSs) in the Observations of Redshift Evolution in Large-Scale Environments (ORELSE) survey, at 0.65 < z < 1.28, using a combination of Chandra observations, optical and NIR imaging and spectroscopy. We located a total of 61 AGNs that were successfully matched to optical counterparts in the LSSs. We found that AGN populations across our sample had more recently had starburst events compared to the overall galaxy populations. We find no relation between AGN activity and location within the LSSs, suggesting triggering mechanisms that depend on global environment are at most sub-dominant. To focus on differences between our AGNs, we grouped them into four sub-samples based on the spectral properties of their parents LSSs. We found one of the sub-samples, SG0023 & SC1604, stood out from the others. AGNs in this sample were disproportionately luminous. These AGNs had the most recent starburst events, in contrast to their parent populations. Additionally, both the AGNs and the overall galaxy population in SG0023 & SC1604 had the largest fraction of close kinematic pairs, which indicates a higher rate of galaxy mergers and interactions. These results suggest that major mergers are driving AGN activity in SG0023 & SC1604, while other processes are likely triggering less luminous AGNs in the rest of our sample. Additionally, minor mergers are unlikely to play a significant role, since the same conditions that lead to more major mergers should also lead to more minor mergers, which is not observed in SG0023 & SC1604

In search of the origins and enduring impact of agile software development

The Agile Manifesto is a philosophical touchpoint for all agile software development (ASD) methods. We examine the manifesto and some of its associated agile methods in an effort to identify the major impacts of ASD. We have encountered some difficulty in delineating agile and non-agile software processes, which is partially the result of terminological confusion. It is clear from the volume of published research that ASD has made a significant contribution, and we have identified two lasting and important impacts. Firstly, the reduction in iteration durations and secondly, the push for reduced levels of documentation (especially in relation to software requirements). Other aspects of the Agile Manifesto may not have exerted a significant impact; for example, the use of tooling to automate processes has become central to continuous software engineering (CSE) and may not be wholly congruent with the manifesto. Furthermore, many organisations may still rely on business contracts despite calls in the manifesto for greater levels of informal customer collaboration

Size Matters: Microservices Research and Applications

In this chapter we offer an overview of microservices providing the introductory information that a reader should know before continuing reading this book. We introduce the idea of microservices and we discuss some of the current research challenges and real-life software applications where the microservice paradigm play a key role. We have identified a set of areas where both researcher and developer can propose new ideas and technical solutions.Comment: arXiv admin note: text overlap with arXiv:1706.0735

Endogenous Syngap1 Alpha Splice Forms Promote Cognitive Function and Seizure Protection

Altres ajuts: NIH grants from the National Institute of Mental Health (MH096847, MH108408, MH115005, MH113949, MH105400); National Institute for Neurological Disorders and Stroke (NS064079); Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD089491); National Institute for Drug Abuse (DA034116, DA036376); Autism Speaks Weatherstone Pre-Doctoral fellowship (10646); Training fellowship from the Leon and Friends Charitable Foundation.Loss-of-function variants in SYNGAP1 cause a developmental encephalopathy defined by cognitive impairment, autistic features, and epilepsy. SYNGAP1 splicing leads to expression of distinct functional protein isoforms. Splicing imparts multiple cellular functions of SynGAP proteins through coding of distinct C-terminal motifs. However, it remains unknown how these different splice sequences function in vivo to regulate neuronal function and behavior. Reduced expression of SynGAP-α1/2 C-terminal splice variants in mice caused severe phenotypes, including reduced survival, impaired learning, and reduced seizure latency. In contrast, upregulation of α1/2 expression improved learning and increased seizure latency. Mice expressing α1-specific mutations, which disrupted SynGAP cellular functions without altering protein expression, promoted seizure, disrupted synapse plasticity, and impaired learning. These findings demonstrate that endogenous SynGAP isoforms with α1/2 spliced sequences promote cognitive function and impart seizure protection. Regulation of SynGAP-α expression or function may be a viable therapeutic strategy to broadly improve cognitive function and mitigate seizure