7 research outputs found
Reference Ranges for the Clinical Laboratory Derived from a Rural Population in Kericho, Kenya
The conduct of Phase I/II HIV vaccine trials internationally necessitates the development of region-specific clinical reference ranges for trial enrolment and participant monitoring. A population based cohort of adults in Kericho, Kenya, a potential vaccine trial site, allowed development of clinical laboratory reference ranges. Lymphocyte immunophenotyping was performed on 1293 HIV seronegative study participants. Hematology and clinical chemistry were performed on up to 1541 cohort enrollees. The ratio of males to females was 1.9∶1. Means, medians and 95% reference ranges were calculated and compared with those from other nations. The median CD4+ T cell count for the group was 810 cells/µl. There were significant gender differences for both red and white blood cell parameters. Kenyan subjects had lower median hemoglobin concentrations (9.5 g/dL; range 6.7–11.1) and neutrophil counts (1850 cells/µl; range 914–4715) compared to North Americans. Kenyan clinical chemistry reference ranges were comparable to those from the USA, with the exception of the upper limits for bilirubin and blood urea nitrogen, which were 2.3-fold higher and 1.5-fold lower, respectively. This study is the first to assess clinical reference ranges for a highland community in Kenya and highlights the need to define clinical laboratory ranges from the national community not only for clinical research but also care and treatment
Clinical Chemistry reference ranges (median and 95th-percentile) derived from HIV-seronegative adults in Kericho, Kenya.
a<p>: P value of <0.05 using the Wilcoxon rank test.</p
Comparison of Lymphocyte Reference Ranges from Kericho, Kenya with those from other countries.
a<p>: Reference ranges provided by Becton-Dickinson with the MultiTEST IMK Kit Reagent package (12/2000;23-3602-02).</p>b<p>:NA-Not Available.</p
Hematology reference ranges (median and 95th-percentile) derived from HIV-seronegative adults in Kericho, Kenya.
a<p>: P value of <0.05 using the Wilcoxon rank test.</p
Hematology reference ranges from Kericho, Kenya compared to other sources in Africa and the United States of America.
a<p>: NA-Not Available.</p