On Board Neuro Fuzzy Inverse Optimal Control for Type 1 Diabetes Mellitus Treatment: In-Silico Testing

Type 1 Diabetes Mellitus (T1DM) is one of the most adverse diseases in the modern era; its treatment is mainly based on exogenous insulin injections. The scientific community has formulated strategies to improve insulin supply using state-of-the-art technology. Therefore, this article develops a multi-age glycemic control scheme, which can be implemented in an Artificial Pancreas (AP) device to enhance diabetics treatment. The procedure is based on the implementation of a neuro-fuzzy inverse optimal control (NFIOC) algorithm on the Texas Instrument LAUNCHXLF28069M development board; this controller communicates with the Uva/Padova simulator for diabetics' patients of different ages under predefined meal protocols running on a Personal Computer (PC). The novelty lies in the proposed NFIOC capability to regulate glucose within safe levels for virtual populations of 10 adults, 10 adolescents and, 10 children. © 2022 AEC