165 research outputs found
Melanoma de extremidades: factores de pronóstico clÃnico, histológico y molecular
Tesis Univ. Granada. Departamento de Medicina. LeÃda el 27 de febrero de 200
Chronic Discoid Lupus: An uncommon cause of nail atrophy
Interesting Medical Imag
Frontal Fibrosing Alopecia: An Observational Single-Center Study of 306 Cases
Background: Frontal fibrosing alopecia (FFA) is a scarring alopecia that predominantly
affects postmenopausal women; (2) Methods: A retrospective, observational, single-center study
was conducted in the Hospital General Universitario in Ciudad Real, Spain, including all patients
diagnosed with FFA between 2010 and 2021; (3) Results: A total of 306 patients (296 women and
10 men) were included in our study. The mean age of onset was 59.5 years. The severity of this disease
was evenly distributed between mild (147 patients) and severe (149 patients) forms. There was
a positive, statistically significant, medium correlation between the severity of the disease and its
time of progression. Moreover, hypothyroidism was present in 70 patients (22.9%) and classic signs of
concomitant lichen planopilaris were observed in just 30 patients (9.8%), while other forms of lichen
planus were uncommon. The estimated prevalence in our population is 0.15% and the incidence
is 15.47 new cases per 100,000 inhabitants; (4) Conclusions: The time of progression was positively
correlated with the severity of FFA. However, the presence of clinical signs, such as inflammatory
trichoscopic signs, was not associated with the progression of this condition
Calcipotriol/Betamethasone Dipropionate Aerosol Foam for Plaque Psoriasis: A Prospective, Observational, Non-Interventional, Single-Center Study of Patient Adherence and Satisfaction in Daily Use
This research was funded by Leo Pharma.Background: Psoriasis is a chronic inflammatory disease that has a negative impact on patients’ quality
of life. Patients with mild–moderate psoriasis can be treated with topical medications, such as the
combination drug calcipotriol/betamethasone dipropionate (Cal/BD).
Objectives: This study investigated the adherence of psoriasis patients to therapy with Cal/BD aerosol
foam, as well as their satisfaction with the treatment’s efficacy, safety, and effect on their quality of life.
Methods: Patients with mild–moderate plaque psoriasis were eligible to participate in this open-label,
non-placebo controlled, prospective single-center study. Adherence to treatment was assessed using the
Morisky-Green scale 4 and 12 weeks after the start of treatment. Satisfaction with the treatment was
assessed using the abbreviated Treatment Satisfaction Questionnaire for Medication (TSQM-9). The
severity of psoriasis was assessed on the mIGA and PGA scales, and the impact on quality of life was
assessed using the PDI and DLQI scales.
Results: A total of 65 patients entered the study. Adherence to treatment was good, with 73.8% of
patients showing high adherence at 12 weeks. Satisfaction was also good, with 46 patients (70.8%)
being completely satisfied. Conclusions: Over a 4-week period, patients treated with Cal/BD aerosol foam had significant improvement
in disease severity that was directly related to treatment adherence.LEO Pharm
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