(1-{2-[2-(2-Ammonio­ethyl­amino)ethyl­amino]ethyl­imino­meth­yl}-2-naphtholato-κ4 O,N,N′,N′′)chloridocopper(II) chloride

In the square-pyramidal title complex, [CuCl(C17H24N4O)]Cl, the CuII atom is coordinated by three N atoms [Cu—N 1.946 (2), 2.010 (2), 2.085 (3) Å], one O atom [Cu—O 1.910 (2) Å] and one apical Cl atom [Cu—Cl 2.6437 (9) Å]. The three coordinated N and one O atom are almost coplanar, with a maximum deviation of 0.0268 Å. The tetra­dentate ligand forms two five-membered (N—Cu—N) and one six-membered (N—Cu—O) chelate rings with bite angles of 84.06 (10), 85.30 (10) and 91.70 (9)°, respectively. The two N—Cu—N chelate rings are non-planar

Bis[2-(2-hydroxy-3-meth­oxy­phen­yl)benzimidazolium] tetrachlorido­cuprate(II) methanol disolvate

In the title compound, (C14H13N2O2)2[CuCl4]·2CH4O, the geometry of the CuC14 2− ions (Cu site symmetry 2) is inter­mediate between tetra­hedral and square-planar. The dihedral angle between the benzimidazole and benzene ring systems is 8.74(14)°. A network of N—H⋯O, N—H⋯Cl and O—H⋯Cl hydrogen bonds helps to consoldiate the structure. Aromatic π–π stacking inter­actions involving the benzimidazole ring system, with a centroid–centroid distance of 3.785 (3) Å, also occur

2-Amino­terephthalic acid–4,4′-bipyridine (1/1)

The asymmetric unit of the title compound, C10H8N2·C8H7NO4, contains two half-mol­ecules, which constitute a 1:1 co-crystal. The 2-amino­terephthalic acid mol­ecule is situated on an inversion center being disordered between two orientations in a 1:1 ratio. In the 4,4′-bipyridine mol­ecule, which is situated on a twofold rotational axis, the two pyridine rings form a dihedral angle of 37.5 (1)°. In the crystal, mol­ecules are held together via inter­molecular N—H⋯O and O—H⋯N hydrogen bonds. The crystal packing exhibits π–π inter­actions between the aromatic rings with a centroid–centroid distance of 3.722 (3) Å

Tetra­kis[(4-meth­oxy­carbon­yl)anilinium] hexa­chloridostannate(IV) dichloride

The asymmetric unit of the title compound, (C8H10NO2)4[SnCl6]Cl2, contains two (4-meth­oxy­carbon­yl)anilinium cations, one chloride anion and one half of a hexa­chlorido­stannate(IV) dianion situated on a twofold rotation axis. All aminium H atoms are involved in N—H⋯Cl hydrogen bonding, which consolidate the crystal packing along with weak C—H⋯O inter­actions

Acetylation Stabilizes ATP-Citrate Lyase to Promote Lipid Biosynthesis and Tumor Growth

Increased fatty acid synthesis is required to meet the demand for membrane expansion of rapidly growing cells. ATP-citrate lyase (ACLY) is upregulated or activated in several types of cancer, and inhibition of ACLY arrests proliferation of cancer cells. Here we show that ACLY is acetylated at lysine residues 540, 546, and 554 (3K). Acetylation at these three lysine residues is stimulated by P300/calcium-binding protein (CBP)-associated factor (PCAF) acetyltransferase under high glucose and increases ACLY stability by blocking its ubiquitylation and degradation. Conversely, the protein deacetylase sirtuin 2 (SIRT2) deacetylates and destabilizes ACLY. Substitution of 3K abolishes ACLY ubiquitylation and promotes de novo lipid synthesis, cell proliferation, and tumor growth. Importantly, 3K acetylation of ACLY is increased in human lung cancers. Our study reveals a crosstalk between acetylation and ubiquitylation by competing for the same lysine residues in the regulation of fatty acid synthesis and cell growth in response to glucose

Bis(1,3-thiazol-2-aminium) hexachloridostannate(IV)

The asymmetric unit of the title compound, (C3H5N2S)2[SnCl6], contains one cation in a general position and one-half of the dianion situated on an inversion center. The geometry of the [SnCl6]2− dianion is almost regular octahedral. In the crystal, weak N—H...Cl and N—H...S hydrogen bonds and electrostatic forces link cations and anions into a three-dimensional framework

Photocatalytic Property of Fe 3 O 4 /SiO 2 /TiO 2 Core-Shell Nanoparticle with Different Functional Layer Thicknesses

This study examined the different properties of Fe 3 O 4 /SiO 2 /TiO 2 (FST) core-shell nanoparticles encapsulated for one to five different times, represented as FST1 to FST5, respectively. These FST nanoparticles were obtained using the carbon reduction and sol-gel methods, and their properties were characterized by various tools, such as scanning electron microscopy, transmission electron microscopy, X-ray diffraction, vibratory sample magnetometer, laser granularity apparatus, and specific surface area analyzer. The relationship between irradiation time and decoloration ratio indicates that FST2 demonstrated significant efficiency in the decolorization of methyl orange (MO) under UV light. Further study on recycle activity showed that FST2 had a high decoloration rate after four cycles of photocatalysis, and its degradation of MO was well aligned with the apparent first-order kinetic equation. Furthermore, FST2 exhibited the highest apparent rate in the first cycle. All these results demonstrate that the recoverable FST2 possessed excellent photocatalytic activity while maintaining outstanding stability for further applications, such as managing environmental pollution