States of the Dirac equation in confining potentials

We study the Dirac equation in confining potentials with pure vector coupling, proving the existence of metastable states with longer and longer lifetimes as the non-relativistic limit is approached and eventually merging with continuity into the Schr\"odinger bound states. We believe that the existence of these states could be relevant in high energy model construction and in understanding possible resonant scattering effects in systems like Graphene. We present numerical results for the linear and the harmonic cases and we show that the the density of the states of the continuous spectrum is well described by a sum of Breit-Wigner lines. The width of the line with lowest positive energy, as expected, reproduces very well the Schwinger pair production rate for a linear potential: we thus suggest a different way of obtaining informations on the pair production in unbounded, non uniform electric fields, where very little is known.Comment: 4 page

The socio-economic value of natural riverbanks in the Netherlands

Abstract Ecologists and economists both use a different approach to determine the value of nature. Its ecological value can be measured using criteria like rarity and diversity of species in an ecosystem. The economic value can be determined using non-market valuation techniques. This paper focuses on an empirical application of the Contingent Valuation Method (CVM) to find out whether this valuation method is a suitable method to estimate the economic value of natural riverbanks in the Netherlands. Natural riverbanks will provide habitat for species that particularly depend on the land water transit area. Since common riverbanks do not provide this habitat, natural river banks increase biodiversity in the Netherlands. On the basis of technical and ecological characteristics nine different types of natural riverbanks were distinguished. For each type a laymen description was made. This description served as a basis for economic valuation by means of CVM. The results of the CVM study shows that the average willingness to pay for non-use of a natural riverbank varied between 16 and 25 Dutch guilders per household year. The willingness to pay for recreational use ranged from 1,07 to 2,50 guilders per visit. The generated outcomes proved to be consistent with results from other studies. At first sight, the economic value of natural riverbanks seemed to be higher than their construction and maintenance cost

Subtherapeutic triazole concentrations as result of a drug-drug interaction with lumacaftor/ivacaftor

Lumacaftor/ivacaftor (Orkambi®, LUM/IVA) is indicated for the treatment of cystic fibrosis (CF) patients aged ≥ 2 years with homozygous F580del mutation in the CFTR gene. Triazole fungal agents are used to treat fungal disease in CF. The use of triazoles is limited by pharmacokinetic challenges, such as drug-drug interactions. The most notable drug-drug interaction between triazoles and LUM/IVA is due to strong induction of CYP3A4 and UGT by LUM. In this real-world retrospective observational study, we described the effect of LUM/IVA on the trough concentration of triazoles. Concomitant use of LUM/IVA with itraconazole, posaconazole or voriconazole resulted in subtherapeutic triazole levels in 76% of the plasma samples. In comparison, in patients with triazole agents without LUM/IVA only 30.6% of the plasma samples resulted in subtherapeutic concentrations. Subtherapeutic plasma concentrations of triazoles should be considered in CF patients on LUM/IVA and further research is warranted for other dosing strategies and alternative antifungal therapy.</p

Subtherapeutic triazole concentrations as result of a drug-drug interaction with lumacaftor/ivacaftor

Lumacaftor/ivacaftor (Orkambi®, LUM/IVA) is indicated for the treatment of cystic fibrosis (CF) patients aged ≥ 2 years with homozygous F580del mutation in the CFTR gene. Triazole fungal agents are used to treat fungal disease in CF. The use of triazoles is limited by pharmacokinetic challenges, such as drug-drug interactions. The most notable drug-drug interaction between triazoles and LUM/IVA is due to strong induction of CYP3A4 and UGT by LUM. In this real-world retrospective observational study, we described the effect of LUM/IVA on the trough concentration of triazoles. Concomitant use of LUM/IVA with itraconazole, posaconazole or voriconazole resulted in subtherapeutic triazole levels in 76% of the plasma samples. In comparison, in patients with triazole agents without LUM/IVA only 30.6% of the plasma samples resulted in subtherapeutic concentrations. Subtherapeutic plasma concentrations of triazoles should be considered in CF patients on LUM/IVA and further research is warranted for other dosing strategies and alternative antifungal therapy.</p

New Results for Diffusion in Lorentz Lattice Gas Cellular Automata

New calculations to over ten million time steps have revealed a more complex diffusive behavior than previously reported, of a point particle on a square and triangular lattice randomly occupied by mirror or rotator scatterers. For the square lattice fully occupied by mirrors where extended closed particle orbits occur, anomalous diffusion was still found. However, for a not fully occupied lattice the super diffusion, first noticed by Owczarek and Prellberg for a particular concentration, obtains for all concentrations. For the square lattice occupied by rotators and the triangular lattice occupied by mirrors or rotators, an absence of diffusion (trapping) was found for all concentrations, except on critical lines, where anomalous diffusion (extended closed orbits) occurs and hyperscaling holds for all closed orbits with {\em universal} exponents ${\displaystyle{d_f = \frac{7}{4}}}$ and ${\displaystyle{\tau = \frac{15}{7}}}$. Only one point on these critical lines can be related to a corresponding percolation problem. The questions arise therefore whether the other critical points can be mapped onto a new percolation-like problem, and of the dynamical significance of hyperscaling.Comment: 52 pages, including 18 figures on the last 22 pages, email: [email protected]

Intrathecal Morphine for Laparoscopic Segmental Colonic Resection as Part of an Enhanced Recovery Protocol: A Randomized Controlled Trial

Background and Objectives: Management of postoperative pain after laparoscopic segmental colonic resections remains controversial. We compared 2 methods of analgesia within an Enhanced Recovery After Surgery (ERAS) program. The goal of the study was to investigate whether admin

The Elliptic Billiard: Subtleties of Separability

Some of the subtleties of the integrability of the elliptic quantum billiard are discussed. A well known classical constant of the motion has in the quantum case an ill-defined commutator with the Hamiltonian. It is shown how this problem can be solved. A geometric picture is given revealing why levels of a separable system cross. It is shown that the repulsions found by Ayant and Arvieu are computational effects and that the method used by Traiber et al. is related to the present picture which explains the crossings they find. An asymptotic formula for the energy-levels is derived and it is found that the statistical quantities of the spectrum P(s) and \Delta(L) have the form expected for an integrable system.Comment: 10 pages, LaTeX, 3 Figures (postscript). Submitted to European Journal of Physic