812 research outputs found
A 300 pc-sized core of Milky Way dark matter halo constrained from the OGLE micro-lensing sky map
We report the detection of a 282 pc-sized core in the center
of Milky Way dark matter halo at confidence level by using the
micro-lensing event rate sky map data from the Optical Gravitational Lensing
Experiment (OGLE) survey. We apply the spacial information of the micro-lensing
sky map and model it with the detailed Milky Way dark matter halo Core/Cusp
profile, and the fraction of dark matter in the form of Mini Dark Matter
Structure (MDMS, ), e.g.
primordial black hole, earth-mass subhalos, floating planets and so on. We find
that this sky map can constrain both and the core size
simultaneously without strong degeneracy while fully considering mass function
of Milky Way stellar components from both the bulge and disk.Comment: 6 pages, 2 figures, 1 tabl
SenseCare: A Research Platform for Medical Image Informatics and Interactive 3D Visualization
Clinical research on smart healthcare has an increasing demand for
intelligent and clinic-oriented medical image computing algorithms and
platforms that support various applications. To this end, we have developed
SenseCare research platform for smart healthcare, which is designed to boost
translational research on intelligent diagnosis and treatment planning in
various clinical scenarios. To facilitate clinical research with Artificial
Intelligence (AI), SenseCare provides a range of AI toolkits for different
tasks, including image segmentation, registration, lesion and landmark
detection from various image modalities ranging from radiology to pathology. In
addition, SenseCare is clinic-oriented and supports a wide range of clinical
applications such as diagnosis and surgical planning for lung cancer, pelvic
tumor, coronary artery disease, etc. SenseCare provides several appealing
functions and features such as advanced 3D visualization, concurrent and
efficient web-based access, fast data synchronization and high data security,
multi-center deployment, support for collaborative research, etc. In this
paper, we will present an overview of SenseCare as an efficient platform
providing comprehensive toolkits and high extensibility for intelligent image
analysis and clinical research in different application scenarios.Comment: 11 pages, 10 figure
Ferroptosis: a new regulatory mechanism in neuropathic pain
Neuropathic pain (NP) is pain caused by damage to the somatosensory system. It is a common progressive neurodegenerative disease that usually presents with clinical features such as spontaneous pain, touch-evoked pain, nociceptive hyperalgesia, and sensory abnormalities. Due to the complexity of the mechanism, NP often persists. In addition to the traditionally recognized mechanisms of peripheral nerve damage and central sensitization, excessive iron accumulation, oxidative stress, neuronal inflammation, and lipid peroxidation damage are distinctive features of NP in pathophysiology. However, the mechanisms linking these pathological features to NP are not fully understood. The complexity of the pathogenesis of NP greatly limits the development of therapeutic approaches for NP. Ferroptosis is a novel form of cell death discovered in recent years, in which cell death is usually accompanied by massive iron accumulation and lipid peroxidation. Ferroptosis-inducing factors can affect glutathione peroxidase directly or indirectly through different pathways, leading to decreased antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. It has been shown that ferroptosis is closely related to the pathophysiological process of many neurological disorders such as NP. Possible mechanisms involved are changes in intracellular iron ion levels, alteration of glutamate excitability, and the onset of oxidative stress. However, the functional changes and specific molecular mechanisms of ferroptosis during this process still need to be further explored. How to intervene in the development of NP by regulating cellular ferroptosis has become a hot issue in etiological research and treatment. In this review, we systematically summarize the recent progress of ferroptosis research in NP, to provide a reference for further understanding of its pathogenesis and propose new targets for treatment
A data analysis method for isochronous mass spectrometry using two time-of-flight detectors at CSRe
The concept of isochronous mass spectrometry (IMS) applying two
time-of-flight (TOF) detectors originated many years ago at GSI. However, the
corresponding method for data analysis has never been discussed in detail.
Recently, two TOF detectors have been installed at CSRe and the new working
mode of the ring is under test. In this paper, a data analysis method for this
mode is introduced and tested with a series of simulations. The results show
that the new IMS method can significantly improve mass resolving power via the
additional velocity information of stored ions. This improvement is especially
important for nuclides with Lorentz factor -value far away from the
transition point of the storage ring CSRe.Comment: published in Chinese Physics C Vol. 39, No. 10 (2015) 10620
CodeApex: A Bilingual Programming Evaluation Benchmark for Large Language Models
With the emergence of Large Language Models (LLMs), there has been a
significant improvement in the programming capabilities of models, attracting
growing attention from researchers. We propose CodeApex, a bilingual benchmark
dataset focusing on the programming comprehension and code generation abilities
of LLMs. CodeApex comprises three types of multiple-choice questions:
conceptual understanding, commonsense reasoning, and multi-hop reasoning,
designed to evaluate LLMs on programming comprehension tasks. Additionally,
CodeApex utilizes algorithmic questions and corresponding test cases to assess
the code quality generated by LLMs. We evaluate 14 state-of-the-art LLMs,
including both general-purpose and specialized models. GPT exhibits the best
programming capabilities, achieving approximate accuracies of 50% and 56% on
the two tasks, respectively. There is still significant room for improvement in
programming tasks. We hope that CodeApex can serve as a reference for
evaluating the coding capabilities of LLMs, further promoting their development
and growth. Datasets are released at https://github.com/APEXLAB/CodeApex.git.
CodeApex submission website is https://apex.sjtu.edu.cn/codeapex/.Comment: 21 page
A High-Speed Asynchronous Data I/O Method for HEPS
The High Energy Photon Source (HEPS) is expected to produce a substantial volume of data, lead to immense data I/O pressure during computing. Inefficient data I/O can significantly impact computing performance.
To address this challenge, firstly, we have developed a data I/O framework for HEPS. This framework consists of three layers: data channel layer, distributed memory management layer, and I/O interface layer. It mask the underlying data differences in formats and sources, while implementing efficient I/O methods. Additionally, it supports both stream computing and batch computing.
Secondly, we have designed a data processing pipeline scheme aimed at reducing I/O latency and optimizing I/O bandwidth utilization during the processing of high-throughput data. This involves breaking down the computing task into several stages, including data loading, data pre-processing, data processing, and data writing, which are executed asynchronously and in parallel.
Finally, we introduce the design of stream data I/O process. The primary objective of stream data I/O is to enable real-time online processing of raw data, avoiding I/O bottlenecks caused by disk storage. This approach ensures the stability of data transmission and integrates distributed memory management to guarantee data integrity in memory
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