Fano resonance in the nonadiabatic pumped shot noise of a time-dependent potential well

We use the Floquet scattering theory to study the correlation properties of the nonadiabatic pumped dc current and heat flow through a time-dependent potential well. Oscillator induced quasibound states of electrons can transit to the Floquet states leading to resonant tunneling effect. Virtual electron scattering processes can produce pumped heat flow, pumped shot noise and pumped heat flow noise, with presence of time and spatial reversal symmetry. When one of the Floquet levels matches the quasibound level there strikes a "Fano" resonance

Chandra Survey of Nearby Galaxies: A Significant Population of Candidate Central Black Holes in Late-type Galaxies

Based on the Chandra data archive as of March 2016, we have identified 314 candidate active galactic nuclei in 719 galaxies located closer than 50 Mpc, among them late-type (Hubble types Sc and later) galaxies that previously had been classified from optical observations as containing star-forming (H II) nuclei. These late-type galaxies comprise a valuable subsample to search for low-mass (<~ 10^6 solar masses) central black holes. For the sample as a whole, the overall dependence of the fraction of active nuclei on galaxy type and nuclear spectral classification is consistent with previous results based on optical surveys. We detect 51 X-ray cores among the 163 H II nuclei and estimate that, very conservatively, ~74% of them with luminosities above 10^38 erg/s are not contaminated by X-ray binaries; the fraction increases to ~92% for X-ray cores with a luminosity of 10^39 erg/s or higher. This allows us to estimate a black hole occupation fraction of >~ 21% in these late-type, many bulgeless, galaxies.Comment: ApJ to appea

Chandra Survey of Nearby Galaxies: The Catalog

We searched in the public archive of the Chandra X-ray Observatory as of March 2016 and assembled a sample of 719 galaxies within 50 Mpc with ACIS observations available. By cross-correlation with the optical or near-infrared nuclei of these galaxies, 314 of them are identified to have an X-ray active galactic nucleus (AGN). The majority of them are low-luminosity AGNs and are unlikely X-ray binaries based upon their spatial distribution and luminosity functions. The AGN fraction is around 60% for elliptical galaxies and early-type spirals, but drops to roughly 20% for Sc and later types, consistent with previous findings in the optical. However, the X-ray survey is more powerful in finding weak AGNs, especially from regions with active star formation that may mask the optical AGN signature. For example, 31% of the H II nuclei are found to harbor an X-ray AGN. For most objects, a single power-law model subject to interstellar absorption is adequate to fit the spectrum, and the typical photon index is found to be around 1.8. For galaxies with a non-detection, their stacked Chandra image shows an X-ray excess with a luminosity of a few times 10^37 erg/s on average around the nuclear region, possibly composed of faint X-ray binaries. This paper reports on the technique and results of the survey; in-depth analysis and discussion of the results will be reported in forthcoming papers.Comment: Accepted for publication in the Astrophysical Journa

Targeting inflammation and neurogenesis in an animal model of small-vessel stroke

Therapeutic strategies of stroke can take two directions: to prevent brain damage from stroke or aid in its repair after a stroke. In this thesis, a rat stroke model, which mimics the human small vessel stroke, was used. Two potential repair strategies were investigated with this model, reduction of inflammatory processes with the aid of minocycline treatment and replacing necrotic neurons with new ones with the aid of neurogenesis of endogenous progenitor cells. The stroke model is induced by disrupting the medium-size pial vessels within a 5mm-circular brain surface of adult Wistar rats. This leads to a cone-shaped cortical lesion. Therefore it mimics the clinical situation of lacunar infarction, the most frequent outcome of small vessel stroke. Minocycline, a second-generation tetracycline, prevented cavitation and facilitated the repopulation of the lesion by reactive astrocytes. However, I could not identify the molecular target as the number of activated microglia, infiltrating leukocytes and CD3+ lymphocytes as well as interleukin-1&#946; expression were not significantly altered. Doublecortin (DCX) is a microtubule-associated protein expressed by migrating neuroblasts and immature neurons. After injury, DCX-positive cells appeared in the neocortex at the base of the lesion. These cells exhibit a morphology resembling differentiated post-migratory neurons with long branched processes. Some of the DCX-positive cells were also immunoreactive for &#946;III-tubulin, another marker of immature neurons. This might indicate a migratory pathway for developing neuroblasts from the subventricular zone (SVZ) through the corpus callosum to the lesion. SVZ cells were labeled with carboxyfluorescein diacetate, succinimidyl ester (CFSE) stereotaxical injections. Although rostral migratory stream and olfactory bulb were intensely labeled, no CFSE containing cells were found in the cortex underneath the lesion. These results suggest that the DCX-positive cells may not originate from neural precursors from the SVZ, but might be generated from local progenitor cells. In summary, using the PVD II model, which mimics the lacunar stroke, I found that neuroblasts appeared spontaneously near the lesion in the cerebral cortex and were attempting to upregulate neuronal properties. Reducing inflammation with post-stroke minocycline treatment prevented cavitation. I think both findings open up exciting new avenues for treatment of lacunar infarctions

The roles of endoglin gene in cerebrovascular diseases.

Endoglin (ENG, also known as CD105) is a transforming growth factor β (TGFβ) associated receptor and is required for both vasculogenesis and angiogenesis. Angiogenesis is important in the development of cerebral vasculature and in the pathogenesis of cerebral vascular diseases. ENG is an essential component of the endothelial nitric oxide synthase activation complex. Animal studies showed that ENG deficiency impairs stroke recovery. ENG deficiency also impairs the regulation of vascular tone, which contributes to the pathogenesis of brain arteriovenous malformation (bAVM) and vasospasm. In human, functional haploinsufficiency of ENG gene causes type I hereditary hemorrhagic telangiectasia (HHT1), an autosomal dominant disorder. Compared to normal population, HHT1 patients have a higher prevalence of AVM in multiple organs including the brain. Vessels in bAVM are fragile and tend to rupture, causing hemorrhagic stroke. High prevalence of pulmonary AVM in HHT1 patients are associated with a higher incidence of paradoxical embolism in the cerebral circulation causing ischemic brain injury. Therefore, HHT1 patients are at risk for both hemorrhagic and ischemic stroke. This review summarizes the possible mechanism of ENG in the pathogenesis of cerebrovascular diseases in experimental animal models and in patients