Diarrhea in young children from low-income countries leads to large-scale alterations in intestinal microbiota composition

Acknowledgments This work was funded in part by the William and Melinda Gates Foundation, award 42917 to JPN and OCS; US National Institutes of Health grants 5R01HG005220 to HCB, 5R01HG004885 to MP; US National Science Foundation Graduate Research Fellowship award DGE0750616 to JNP; AWW and JP are funded by The Wellcome Trust (Grant No. WT098051).Peer reviewedPublisher PD

Designing a broad-spectrum integrative approach for cancer prevention and treatment

Targeted therapies and the consequent adoption of “personalized” oncology have achieved notable successes in some cancers; however, significant problems remain with this approach. Many targeted therapies are highly toxic, costs are extremely high, and most patients experience relapse after a few disease-free months. Relapses arise from genetic heterogeneity in tumors, which harbor therapy-resistant immortalized cells that have adopted alternate and compensatory pathways (i.e., pathways that are not reliant upon the same mechanisms as those which have been targeted). To address these limitations, an international task force of 180 scientists was assembled to explore the concept of a low-toxicity “broad-spectrum” therapeutic approach that could simultaneously target many key pathways and mechanisms. Using cancer hallmark phenotypes and the tumor microenvironment to account for the various aspects of relevant cancer biology, interdisciplinary teams reviewed each hallmark area and nominated a wide range of high-priority targets (74 in total) that could be modified to improve patient outcomes. For these targets, corresponding low-toxicity therapeutic approaches were then suggested; many of which were phytochemicals. Proposed actions on each target and all of the approaches were further reviewed for known effects on other hallmark areas and the tumor microenvironment. Potential contrary or procarcinogenic effects were found for 3.9% of the relationships between targets and hallmarks, and mixed evidence of complementary and contrary relationships was found for 7.1%. Approximately 67% of the relationships revealed potentially complementary effects, and the remainder had no known relationship. Among the approaches, 1.1% had contrary, 2.8% had mixed and 62.1% had complementary relationships. These results suggest that a broad-spectrum approach should be feasible from a safety standpoint. This novel approach has potential to help us address disease relapse, which is a substantial and longstanding problem, so a proposed agenda for future research is offered

Renewable Energy-Based Energy-Efficient Off-Grid Base Stations for Heterogeneous Network

The heterogeneous network (HetNet) is a specified cellular platform to tackle the rapidly growing anticipated data traffic. From a communications perspective, data loads can be mapped to energy loads that are generally placed on the operator networks. Meanwhile, renewable energy-aided networks offer to curtailed fossil fuel consumption, so to reduce the environmental pollution. This paper proposes a renewable energy based power supply architecture for the off-grid HetNet using a novel energy sharing model. Solar photovoltaics (PV) along with sufficient energy storage devices are used for each macro, micro, pico, or femto base station (BS). Additionally, a biomass generator (BG) is used for macro and micro BSs. The collocated macro and micro BSs are connected through end-to-end resistive lines. A novel-weighted proportional-fair resource-scheduling algorithm with sleep mechanisms is proposed for non-real time (NRT) applications by trading-off the power consumption and communication delays. Furthermore, the proposed algorithm with an extended discontinuous reception (eDRX) and power saving mode (PSM) for narrowband internet of things (IoT) applications extends the battery lifetime for IoT devices. HOMER optimization software is used to perform optimal system architecture, economic, and carbon footprint analyses while the Monte-Carlo simulation tool is used for evaluating the throughput and energy efficiency performances. The proposed algorithms are validated through the practical data of the rural areas of Bangladesh from which it is evident that the proposed power supply architecture is energy-efficient, cost-effective, reliable, and eco-friendly

Renewable Energy-Based Energy-Efficient Off-Grid Base Stations for Heterogeneous Network

The heterogeneous network (HetNet) is a specified cellular platform to tackle the rapidly growing anticipated data traffic. From a communications perspective, data loads can be mapped to energy loads that are generally placed on the operator networks. Meanwhile, renewable energy-aided networks offer to curtailed fossil fuel consumption, so to reduce the environmental pollution. This paper proposes a renewable energy based power supply architecture for the off-grid HetNet using a novel energy sharing model. Solar photovoltaics (PV) along with sufficient energy storage devices are used for each macro, micro, pico, or femto base station (BS). Additionally, a biomass generator (BG) is used for macro and micro BSs. The collocated macro and micro BSs are connected through end-to-end resistive lines. A novel-weighted proportional-fair resource-scheduling algorithm with sleep mechanisms is proposed for non-real time (NRT) applications by trading-off the power consumption and communication delays. Furthermore, the proposed algorithm with an extended discontinuous reception (eDRX) and power saving mode (PSM) for narrowband internet of things (IoT) applications extends the battery lifetime for IoT devices. HOMER optimization software is used to perform optimal system architecture, economic, and carbon footprint analyses while the Monte-Carlo simulation tool is used for evaluating the throughput and energy efficiency performances. The proposed algorithms are validated through the practical data of the rural areas of Bangladesh from which it is evident that the proposed power supply architecture is energy-efficient, cost-effective, reliable, and eco-friendly

Cancer prevention with natural compounds

Botanical and nutritional compounds have been used for the treatment of cancer throughout history. These compounds also may be useful in the prevention of cancer. Population studies suggest that a reduced risk of cancer is associated with high consumption of vegetables and fruits. Thus, the cancer chemopreventive potential of naturally occurring phytochemicals is of great interest. There are numerous reports of cancer chemopreventive activity of dietary botanicals, including cruciferous vegetables such as cabbage and broccoli, Allium vegetables such as garlic and onion, green tea, Citrus fruits, soybeans, tomatoes, berries, and ginger, as well as medicinal plants. Several lead compounds, such as genistein (from soybeans), lycopene (from tomatoes), brassinin (from cruciferous vegetables), sulforaphane (from asparagus), indole-3-carbinol (from broccoli), and resveratrol (from grapes and peanuts) are in preclinical or clinical trials for cancer chemoprevention. Phytochemicals have great potential in cancer prevention because of their safety, low cost, and oral bioavailability. In this review, we discuss potential natural cancer preventive compounds and their mechanisms of action. Semin Oncol 37:258-281. (C) 2010 Published by Elsevier Inc

A 50-kDa ERK-like protein is up-regulated by a dual altered peptide ligand that suppresses myasthenia gravis-associated responses

Myasthenia gravis (MG) and its animal model, experimental autoimmune MG (EAMG), are T cell-dependent antibody-mediated autoimmune diseases. A dual altered peptide ligand (APL) that is composed of the tandemly arranged two single amino acid analogues of two myasthenogenic peptides, p195–212 and p259–271, down-regulated in vitro and in vivo MG-associated autoreactive responses. The dual APL was shown to exert its beneficial effects by up-regulating ERK1,2 in CD4(+)CD25(+) regulatory cells. In this study, we investigated a novel 50-kDa ERK-like protein (ERK-50) that is up-regulated significantly in addition to ERK1,2 after treatment with the dual APL. We report here that ERK-50 was up-regulated in LN cells and in LN-derived T cells of mice that were immunized with the myasthenogenic peptides and treated with the dual APL. Moreover, ERK-50 was up-regulated in dual-APL- treated mice that were immunized with the Torpedo acetylcholine receptor. ERK-50 was demonstrated to be recognized by antibodies directed against the C and N termini of ERK1, against the C terminus of ERK2, and against general ERK. The 50-kDa ERK was shown to be stimulated by Con A, and inhibition of MEK1 down-regulated the 50-kDa ERK as was shown for ERK1,2. However, 4β-phorbol 12-myristate 13-acetate (TPA) did not stimulate ERK-50. Finally, the activated ERK-50 was up-regulated in the dual-APL-induced CD4(+)CD25(+) regulatory cells. Thus, ERK-50 is suggested to be a novel ERK isoform, being up-regulated in response to treatment with the dual APL