Laser beam micro welding of dissimilar metals

The combination of dissimilar materials like brass and stainless steel is often needed in watch movements due to tribologic aspects. For mass production in automotive applications, a joining technique for alloyed copper with alloyed steel is needed. Laser beam micro welding offers an alternative to conventional joining techniques like press fit or soldering. The laser beam micro welding of stainless steel (X5CrNi1810) to copper (CuNi3SiMg) and brass (CuZn37) with a fiber-guided pulsed Nd:YAG laser is investigated. The weld seams are produced with the SHADOW-Welding: one single pulse with high feed rate by beam movement or part movement. The joint configurations are t-joints. High strength and reproducibility as well as good appearance are the main objective of joining dissimilar metals. Cracks and spatter formation are affected by the different physical properties and should be avoided. The welding results of joint configurations as well as welded parts are presented. T he length of the continuous welding seams are up to 15.7 mm at a feed rate of up to 60 m/min. The weld width attained is from 50 to 250 m and a weld depth from 20 to 150 m. This low energy joining process with minimized head input results in low distortion of the parts joined

Inactivated poliovirus vaccine given alone or in a sequential schedule with bivalent oral poliovirus vaccine in Chilean infants: a randomised, controlled, open-label, phase 4, non-inferiority study

Artículo de publicación ISIBackground Bivalent oral poliovirus vaccine (bOPV; types 1 and 3) is expected to replace trivalent OPV (tOPV) globally by April, 2016, preceded by the introduction of at least one dose of inactivated poliovirus vaccine (IPV) in routine immunisation programmes to eliminate vaccine-associated or vaccine-derived poliomyelitis from serotype 2 poliovirus. Because data are needed on sequential IPV bOPV schedules, we assessed the immunogenicity of two different IPV bOPV schedules compared with an all-IPV schedule in infants. Methods We did a randomised, controlled, open-label, non-inferiority trial with healthy, full-term (>2.5 kg birthweight) infants aged 8 weeks (+/- 7 days) at six well-child clinics in Santiago, Chile. We used supplied lists to randomly assign infants (1:1:1) to receive three polio vaccinations (IPV by injection or bOPV as oral drops) at age 8,16, and 24 weeks in one of three sequential schedules: IPV bOPV bOPV, IPV IPV bOPV, or IPV IPV IPV. We did the randomisation with blocks of 12 stratified by study site. All analyses were done in a masked manner. Co-primary outcomes were non-inferiority of the bOPV-containing schedules compared with the all-IPV schedule for seroconversion (within a 10% margin) and antibody titres (within two-thirds log(2) titres) to poliovirus serotypes land 3 at age 28 weeks, analysed in the per-protocol population. Secondary outcomes were seroconversion and titres to serotype 2 and faecal shedding for 4 weeks after a monovalent OPV type 2 challenge at age 28 weeks. Safety analyses were done in the intention-to-treat population. This trial is registered with ClinicalTrials.gov, number NCT01841671, and is dosed to new participants. Findings Between April 25 and August 1,2013, we assigned 570 infants to treatment: 190 to IPV bOPV bOPV, 192 to IPV IPV bOPV, and 188 to IPV IPV IPV. 564 (99%) were vaccinated and included in the intention-to-treat cohort, and 537 (94%) in the per-protocol analyses. In the IPV bOPV bOPV, IPV IPV bOPV, and IPV IPV IPV groups, respectively, the proportions of children with seroconversion to type 1 poliovirus were 166 (98.8%) of 168,95% CI 95-8-99.7; 178 (100%), 97.9-100-0; and 175 (100%), 97.9-100.0. Proportions with seroconvsion to type 3 poliovirus were 163 (98.2%) of 166,94.8-99.4; 177(100%), 97.9-100-0, and 172(98.9%) of 174,95.9-99.7. Non-inferiority was thus shown for the bOPV-containing schedules compared with the all-IPV schedule, with no significant differences between groups. In the IPV bOPV bOPV, IPV IPV bOPV, and IPV IPV IPV groups, respectively, the proportions of children with seroprotective antibody titres to type 1 poliovirus were 168 (98-8%) of 170, 95% CI 95-8-99.7; 181 (100%), 97.9-100.0; and 177 (100%), 97.9-100.0. Proportions to type 3 poliovirus were 166 (98-2%) of 169, 94.9-99.4; 180 (100%), 97-9400.0; and 174 (98.9%) of 176,96.0-99.7. Non-inferiority comparisons could not be done for this outcome because median litres for the groups receiving OPV were greater than the assay's upper limit of detection (log2 titres >10.5). The proportions of children seroconverting to type 2 poliovirus in the IPV bOPV bOPV, IPV IPV bOPV, and IPV IPV IPV groups, respectively, were 130 (77.4%) of 168, 95% CI 70.5-83.0; 169 (96.0%) of 176,92.0-98.0; and 175 (100%), 97.8-100. IPV bOPV schedules resulted in almost a 0.3 log reduction of type 2 faecal shedding compared with the IPV-only schedule. No participants died during the trial; 81 serious adverse events were reported, of which one was thought to be possibly vaccine-related (intestinal intussusception). Interpretation Seroconversion rates against polioviruses types 1 and 3 were non-inferior in sequential schedules containing IPV and bOPV, compared with an all-IPV schedule, and proportions of infants with protective antibodies were high after all three schedules. One or two doses of bOPV after IPV boosted intestinal immunity for poliovirus type 2, suggesting possible cross protection. Additionally, there was evidence of humoral priming for type 2 from one dose of IPV. Our findings could give policy makers flexibility when choosing a vaccination schedule, especially when trying to eliminate vaccine-associated and vaccine-derived poliomyelitis