From Genomic Advances to Public Health Benefits: The Unbearable Lightness of Being Stuck

Genetic determinants of common human diseases are still poorly understood. Due to large investments, many small successes have been made and the research field is rapidly expanding. However, genetic susceptibility variants showing repeatable associations with common diseases are usually of small effect. They are therefore unlikely to individually explain substantial share of disease burden in any community or provide new insights into disease pathogenesis that could lead to development of new drugs effective in considerable portion of the disease cases in a population. Genetic architecture of common diseases is beginning to reveal an incredible diversity of potential genetic causes that act through somewhat limited number of mechanisms with important contribution of environmental interactions. In light of these findings, we present current understanding of genetic architecture of a spectrum of human diseases. We address the encountered problems in susceptibility gene identification, review the success of leading gene identification strategies and discuss current prospects for translating genomic advances into measurable public health benefits

Foundation and development of Department of biological anthropology at Faculty of medicine Osijek

U radu je prikazan osnutak i djelovanje Zavoda za biološku antropologiju Medicinskoga fakulteta u Osijeku. Antropologija je vrlo kompleksna znanost obilježena interdisciplinarnošću, a u njezinu je fokusu uvijek čovjek. U Hrvatskoj bavljenje antropologijom počinje od 1974. godine. Sveučilište Josipa Jurja Strossmayera u Osijeku u svoj korpus ovu znanost uvodi baš osnutkom Zavoda za antropologiju na svome Medicinskom fakultetu – 2010. godine. Predstojnik Zavoda za biološku antropologiju Medicinskoga fakulteta u Osijeku od njegovoga osnutka do danas je akademik Pavao Rudan.This review describes foundation and activities at the Department of Biological Anthropology of the Faculty of Medicine Osijek. Anthropology is a very complex interdisciplinary science with a human being as a focus of scientific research. Anthropology research in Croatia started in 1974. Anthropology research at Josip Juraj Strossmayer University of Osijek began in the year 2010 when the Department of Biological Anthropology at Osijek Medical Faculty was founded. Since foundation of the Department of Biological Anthropology at Osijek Faculty of Medicine the Head of the Department has been Pavao Rudan, Fellow of the Croatian Academy of Sciences and Art

Foundation and development of Department of biological anthropology at Faculty of medicine Osijek

U radu je prikazan osnutak i djelovanje Zavoda za biološku antropologiju Medicinskoga fakulteta u Osijeku. Antropologija je vrlo kompleksna znanost obilježena interdisciplinarnošću, a u njezinu je fokusu uvijek čovjek. U Hrvatskoj bavljenje antropologijom počinje od 1974. godine. Sveučilište Josipa Jurja Strossmayera u Osijeku u svoj korpus ovu znanost uvodi baš osnutkom Zavoda za antropologiju na svome Medicinskom fakultetu – 2010. godine. Predstojnik Zavoda za biološku antropologiju Medicinskoga fakulteta u Osijeku od njegovoga osnutka do danas je akademik Pavao Rudan.This review describes foundation and activities at the Department of Biological Anthropology of the Faculty of Medicine Osijek. Anthropology is a very complex interdisciplinary science with a human being as a focus of scientific research. Anthropology research in Croatia started in 1974. Anthropology research at Josip Juraj Strossmayer University of Osijek began in the year 2010 when the Department of Biological Anthropology at Osijek Medical Faculty was founded. Since foundation of the Department of Biological Anthropology at Osijek Faculty of Medicine the Head of the Department has been Pavao Rudan, Fellow of the Croatian Academy of Sciences and Art

Foundation and development of Department of biological anthropology at Faculty of medicine Osijek

U radu je prikazan osnutak i djelovanje Zavoda za biološku antropologiju Medicinskoga fakulteta u Osijeku. Antropologija je vrlo kompleksna znanost obilježena interdisciplinarnošću, a u njezinu je fokusu uvijek čovjek. U Hrvatskoj bavljenje antropologijom počinje od 1974. godine. Sveučilište Josipa Jurja Strossmayera u Osijeku u svoj korpus ovu znanost uvodi baš osnutkom Zavoda za antropologiju na svome Medicinskom fakultetu – 2010. godine. Predstojnik Zavoda za biološku antropologiju Medicinskoga fakulteta u Osijeku od njegovoga osnutka do danas je akademik Pavao Rudan.This review describes foundation and activities at the Department of Biological Anthropology of the Faculty of Medicine Osijek. Anthropology is a very complex interdisciplinary science with a human being as a focus of scientific research. Anthropology research in Croatia started in 1974. Anthropology research at Josip Juraj Strossmayer University of Osijek began in the year 2010 when the Department of Biological Anthropology at Osijek Medical Faculty was founded. Since foundation of the Department of Biological Anthropology at Osijek Faculty of Medicine the Head of the Department has been Pavao Rudan, Fellow of the Croatian Academy of Sciences and Art

Genetic Diversity of 15 STR Loci in a Population of Montenegro

Genetic diversity and forensic parameters based on 15 AmpFlSTR Identifiler short tandem repeat (STR) loci (D8S1179, D21S11, D7S820, CSF1PO, D3S1358, TH01, D13S317, D16S539, D2S1338, D19S433, vWA, TPOX, D18S51, D5S818 and FGA) were evaluated in a sample of 101 unrelated, autochthonous adults from Montenegro. After applying Bonferroni correction, the agreement with Hardy-Weinberg equilibrium (HWE) was confirmed for all loci with the exception of D5S818 (c 2 test) and D21S11 (exact test). The combined power of discrimination (PD) and the combined power of exclusion (PE) for the 15 studied loci were 0.9999999999999999844 and 0.99999382, respectively. According to measures of within-population genetic diversity, D2S1338, D18S51 and FGA may be considered as the most variable and most informative markers for forensic testing and population genetic analyses out of the 15 analysed loci in a population of Montenegro. D5S818 showed to be the least variable and together with TPOX, the least informative. Interpopulation comparisons were carried out and levels of genetic differentiation between population ofMontenegro and five South-eastern European populations (Kosovo Albanians, Serbians from Vojvodina province, Macedonians, Bosnians and Croatians) were evaluated. The most differentiated population in relation to Montenegro is a population of Kosovo Albanians as suggested by both AMOVA and coefficients of genetic differentiation (FST and RST)

Impact Analysis of a Regional Scientific Journal (1980–2000): Supporting Promising Local Researchers Pays the Greatest Dividends

During the past 28 years, the journal »Collegium Antropologicum« has continuously served as one of the main disseminators of anthropological scientific production in Central and Eastern Europe. The journal was committed to its role of a multidisciplinary platform for presenting wide range of research topics relevant to anthropology, from investigations within social and cultural anthropology and archaeology to those covering contemporary population genetics, human evolution and biomedical issues. Two key strategies aimed at sustaining and increasing the impact of this journal were oriented towards: i) identification of promising local groups of researchers who were at disadvantageby many aspects (e.g. educational curricula, financial supports, language barriers etc.) when trying to publish their research internationally, and ii) invitation and encouragement of already established international scientists to make contributions for »Collegium Antropologicum«. From 1980–2000, 89 articles (or 6.3% of all published papers duringthat period) were cited 6 or more times, contributing disproportionately to journal’s impact (nearly a third of all citations received). In an attempt to identify such papers more readily among the submissions to the journal in the future, we analyzed research topics and affiliations of the authors among the 89 papers receiving most citations in comparison to all papers published. Among the papers most frequently cited, we found greater-than-expected prevalence of Croatian researchers (especially when publishing in collaboration with international scientists) and studies of special populations. Several papers received more than 25 citations or had overall citation intensity greater than 2 per year.This implies that an interesting article from a local group of researchers can still resonate with international audience although published in a regional journal. Present analysis supports current editorial strategy that with a help of the international .consulting editorial board continuously improves international recognition of this journal. The results imply that a balanced encouragement to promising local groups of researchers and to contributions of already established international scientists is a strategy superior to others in maintaining and increasing the impact of this regional journal

Impact Analysis of a Regional Scientific Journal (1980–2000): Supporting Promising Local Researchers Pays the Greatest Dividends

During the past 28 years, the journal »Collegium Antropologicum« has continuously served as one of the main disseminators of anthropological scientific production in Central and Eastern Europe. The journal was committed to its role of a multidisciplinary platform for presenting wide range of research topics relevant to anthropology, from investigations within social and cultural anthropology and archaeology to those covering contemporary population genetics, human evolution and biomedical issues. Two key strategies aimed at sustaining and increasing the impact of this journal were oriented towards: i) identification of promising local groups of researchers who were at disadvantageby many aspects (e.g. educational curricula, financial supports, language barriers etc.) when trying to publish their research internationally, and ii) invitation and encouragement of already established international scientists to make contributions for »Collegium Antropologicum«. From 1980–2000, 89 articles (or 6.3% of all published papers duringthat period) were cited 6 or more times, contributing disproportionately to journal’s impact (nearly a third of all citations received). In an attempt to identify such papers more readily among the submissions to the journal in the future, we analyzed research topics and affiliations of the authors among the 89 papers receiving most citations in comparison to all papers published. Among the papers most frequently cited, we found greater-than-expected prevalence of Croatian researchers (especially when publishing in collaboration with international scientists) and studies of special populations. Several papers received more than 25 citations or had overall citation intensity greater than 2 per year.This implies that an interesting article from a local group of researchers can still resonate with international audience although published in a regional journal. Present analysis supports current editorial strategy that with a help of the international .consulting editorial board continuously improves international recognition of this journal. The results imply that a balanced encouragement to promising local groups of researchers and to contributions of already established international scientists is a strategy superior to others in maintaining and increasing the impact of this regional journal