Therapeutic alternatives for the prevention of intra peritoneal adhesions

Intestinal adhesions are bands of fibrous tissue created by the intimate contact of two injured surface tissues; these appear in 93% of the patient undergoing intra-abdominal or gastrointestinal surgery. The comorbidities associated with the formation of adhesions have an impact on quality care offered to patients, leading to an increase in healthcare. Goals of this study was to perform a review that includes different therapeutic alternatives in basic and clinical research to prevent the formation of postoperative abdominal peritoneal adhesions. A bibliographic search was conducted in different databases including Pub med, Medline, Cochrane, science direct, from the years 2000 to 2018 using the keywords: gastrointestinal adhesions, small bowel obstruction, prophylaxis, treatment. Only experimental and clinical articles were selected. The development of peritoneal adhesions in most of the experimental studies occurred with cecal abrasion, studying the effect of biodegradable materials, drugs and gels such as mXG Hydrogel. Nanofiber membranes, agents created with recombinant technology such as periostin antisense oligonucleotide and aerosol applications such as polysaccharide 4DryField PH, are positioned to replace in the future the actual limited mechanical barriers application commonly used in abdominal surgery such as seprafilm and interceed. There are several anti-adhesion agents in experimental phase with different mechanism of action that could be used in the short term to prevent the formation of post-surgical intestinal adhesions. The inclusion of gastrointestinal surgeons in basic research is increasing and necessary with multidisciplinary collaboration. It is expected in short term the study and development of a greater number of materials to minimize tissue trauma and decrease the formation of post-surgical adhesions

La Rábida : Revista Colombina Hispanoamericana. Número 179 - Año XVII

36 páginasPérez Nieva, Alfonso: Aguas fuertes Colombinas. Segundo viaje. Undécima estampa.- Bersandín: Desde Madrid. De Acá y de Allá.- Marchena Colombo, José: Desde la Sierra. Cartas íntimas (XXV).- Mistral, Gabriela: Poesía. Venganza.- La Sociedad de Naciones y la Paz.- Punta Umbría (con fotografías).- La campana de Huesca.- Sáenz, Vicente: El Imperialismo de EE.UU. con republicanos y demócratas en el poder, ha sido invariable desde 1898.- Pulido, José: Así habla la voz de la cultura.- Santos Chocano, José: El amor de los Andes.- Una cosa es predicar... (sobre el Tratado Bryan-Chamorro).- D. José León Suárez (necrológica).- Solemne inauguración de la "Casa de España" en Roma.- Marchena Colombo: Excmo. Sr. D. Aníbal González y Álvarez Ossorio (necrológica).- Naveda, César A. Hacia un partido político continental.- Sobre el número extraordinario editado por "La Nación" de Buenos Aires.- Pérez Nieva: Cielo y Agua... Cielo y Agua... (reseña de la obra María A. de Burgos)