Numerical simulations of divergence-type theories for conformal dissipative fluids

We present the first numerical simulations of the symmetric--hyperbolic theory for conformal dissipative relativistic fluids developed in [1]. In this theory, the information of the fluid dynamics is encoded in a scalar generating function which depends on three free parameters. By adapting the WENO-Z high-resolution shock-capturing central scheme, we show numerical solutions restricted to planar symmetry in Minkowski spacetime, from two qualitatively different initial data: a smooth bump and a discontinuous step. We perform a detailed exploration of the effect of the different parameters of the theory, and numerically assess the constitutive relations associated with the shear viscosity by analyzing the entropy production rate when shocks are produced.Comment: 22 pages, 14 figure

Isotropization of a rotating and longitudinally expanding ϕ4\phi^4 scalar system

We present numerical simulations for the evolution of an expanding system of massless scalar fields with quartic coupling. By setting a rotating, non-isotropic initial configuration, we compute the energy density, the transverse and longitudinal pressures and the angular momentum of the system. We compare the time scales associated with the isotropization and the decay of the initial angular momentum due to the expansion, and show that even for fairly large initial angular momentum, it decays significantly faster than the pressure anisotropy.Comment: 15 pages, 6 figure

Well-posed evolution of field theories with anisotropic scaling: the Lifshitz scalar field in a black hole space-time

Partial differential equations exhibiting an anisotropic scaling between space and time -- such as those of Horava-Lifshitz gravity -- have a dispersive nature. They contain higher-order spatial derivatives, but remain second order in time. This is inconvenient for performing long-time numerical evolutions, as standard explicit schemes fail to maintain convergence unless the time step is chosen to be very small. In this work, we develop an implicit evolution scheme that does not suffer from this drawback, and which is stable and second-order accurate. As a proof of concept, we study the numerical evolution of a Lifshitz scalar field on top of a spherically symmetric black hole space-time. We explore the evolution of a static pulse and an (approximately) ingoing wave-packet for different strengths of the Lorentz-breaking terms, accounting also for the effect of the angular momentum eigenvalue and the resulting effective centrifugal barrier. Our results indicate that the dispersive terms produce a cascade of modes that accumulate in the region in between the Killing and universal horizons, indicating a possible instability of the latter.Comment: 22 pages, 8 figures, 1 table, comments are welcome

Dark matter from primordial black holes would hold charge

We explore the possibility that primordial black holes (PBHs), formed early in the history of the Universe, contain electric charge down to the present day. We find that PBHs should hold a non-zero charge at their formation, sourced by both Poisson fluctuations and collisions of charged particles in the early universe. Although initial charges could be of either sign and are thought to be subject to fast discharge processes, we show that dipolar magnetic fields from rotating black holes can deviate them, avoiding their accretion or emission to infinity, regardless of the PBH mass. Moreover, we find that charged, maximally rotating PBHs produce magnetic fields able to cancel the Schwinger effect for all masses, and the Hawking emission for PBHs with M>1\,\mbox{kg}. These mechanisms could allow PBHs to maintain their charge for extended periods. At late times, we conclude that the plasma within virialised dark matter haloes can endow PBHs with a net average negative charge. We report resulting charges Q/M \sim -10^{-32}\,C/\mbox{kg} and Q/M \sim -10^{-22}\,C/\mbox{kg} for two current windows where PBHs can make up all of the dark matter; being respectively M\sim 10^{20}\,\mbox{kg} and M\sim 10^{30}\,\mbox{kg}. The charge of PBHs in haloes lies below the Schwinger limit for discharge, which would effectively make PBH dark matter slightly non-neutral to the present day. Altogether, the initial PBH charge, possible shielding against discharge, and late time negative charge accretion, show that PBHs of all masses could hold a net charge, with values about two to ten orders of magnitude lower than the maximal bound imposed by subextremal Reissner-Nordstr\"om (RN) PBHs, and even the extremal charge for Planck mass PBHs. The latter are of particular interest, as they could constitute charged stable relics, composing the entirety of dark matter in the Universe.Comment: 24 pages, 6 figures, minor changes, matches the version submitted to the journa

HLA-Driven Convergence of HIV-1 Viral Subtypes B and F Toward the Adaptation to Immune Responses in Human Populations

BACKGROUND: Cytotoxic T-Lymphocyte (CTL) response drives the evolution of HIV-1 at a host-level by selecting HLA-restricted escape mutations. Dissecting the dynamics of these escape mutations at a population-level would help to understand how HLA-mediated selection drives the evolution of HIV-1. METHODOLOGY/PRINCIPAL FINDINGS: We undertook a study of the dynamics of HIV-1 CTL-escape mutations by analyzing through statistical approaches and phylogenetic methods the viral gene gag sequenced in plasma samples collected between the years 1987 and 2006 from 302 drug-naive HIV-positive patients. By applying logistic regression models and after performing correction for multiple test, we identified 22 potential CTL-escape mutations (p-value<0.05; q-value<0.2); 10 of these associations were confirmed in samples biologically independent by a Bayesian Markov Chain Monte-Carlo method. Analyzing their prevalence back in time we found that escape mutations that are the consensus residue in samples collected after 2003 have actually significantly increased in time in one of either B or F subtype until becoming the most frequent residue, while dominating the other viral subtype. Their estimated prevalence in the viral subtype they did not dominate was lower than 30% for the majority of samples collected at the end of the 80's. In addition, when screening the entire viral region, we found that the 75% of positions significantly changing in time (p<0.05) were located within known CTL epitopes. CONCLUSIONS: Across HIV Gag protein, the rise of polymorphisms from independent origin during the last twenty years of epidemic in our setting was related to an association with an HLA allele. The fact that these mutations accumulated in one of either B or F subtypes have also dominated the other subtype shows how this selection might be causing a convergence of viral subtypes to variants which are more likely to evade the immune response of the population where they circulate

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Global disparities in surgeons’ workloads, academic engagement and rest periods: the on-calL shIft fOr geNEral SurgeonS (LIONESS) study

: The workload of general surgeons is multifaceted, encompassing not only surgical procedures but also a myriad of other responsibilities. From April to May 2023, we conducted a CHERRIES-compliant internet-based survey analyzing clinical practice, academic engagement, and post-on-call rest. The questionnaire featured six sections with 35 questions. Statistical analysis used Chi-square tests, ANOVA, and logistic regression (SPSS® v. 28). The survey received a total of 1.046 responses (65.4%). Over 78.0% of responders came from Europe, 65.1% came from a general surgery unit; 92.8% of European and 87.5% of North American respondents were involved in research, compared to 71.7% in Africa. Europe led in publishing research studies (6.6 ± 8.6 yearly). Teaching involvement was high in North America (100%) and Africa (91.7%). Surgeons reported an average of 6.7 ± 4.9 on-call shifts per month, with European and North American surgeons experiencing 6.5 ± 4.9 and 7.8 ± 4.1 on-calls monthly, respectively. African surgeons had the highest on-call frequency (8.7 ± 6.1). Post-on-call, only 35.1% of respondents received a day off. Europeans were most likely (40%) to have a day off, while African surgeons were least likely (6.7%). On the adjusted multivariable analysis HDI (Human Development Index) (aOR 1.993) hospital capacity &gt; 400 beds (aOR 2.423), working in a specialty surgery unit (aOR 2.087), and making the on-call in-house (aOR 5.446), significantly predicted the likelihood of having a day off after an on-call shift. Our study revealed critical insights into the disparities in workload, access to research, and professional opportunities for surgeons across different continents, underscored by the HDI