An experiment in the prediction of children's reactions to stress by means of psychological test measures

Thesis (Ph.D.)--Boston UniversityI. INTRODUCTION The present study was an experiment to examine the use of two psychological tests, the Wechsler Intelligence Scale for Children (WISC) and the Rorschach Test in the prediction of children's adjustment to stress. The purpose of this research was to investigate some of the formulations underlying the use of these tests in the diagnosis of personality adjustment. The variations in performance on several test measures were related to the variations in behavioral adjustment to stress of a group of children hospitalized for an operation. II. SURVEY OF THE LITERATURE The literature relvant to the general theory of psychological test measurement was reviewed. In addition, some of the assumptions underlying the use of the WISC and the Rorschach were outlined and discussed. Specific measures derived from these tests were listed and the psychological rationale for each was presented and discussed. Several approaches to the methodology most applicable to validation research were investigated and the conclusions relevant to this study that were drawn suggested an experimental procedure, involving the comparison of individual test scores from the WISC and of sign scores from the Rorschach with a criterion of adjustment defined in behavioral terms. The concept of stress, its use in experimental investigations and its relation to trauma, were presented. The contributions of several authors to the understanding of these two concepts were also reviewed. Finally, previous experimental studies of the use of psychological tests in the prediction of adjustment to stress were critically reviewed. III. EXPERIMENTAL DESIGN The general hypothesis was than formulated as: The perfonnance on psychological tests may be used in the prediction of children's reactions to a situation of stress. The proposition was to be tested making use of the measures derived from the WISC and the Rorschach. The general procedure used in both experiments was the same and was presented in detail, including the experimental conditions, the materials used and the nature of the sample. The experimental conditions involved testing of subjects while hospitalized for a tonsillectomy and adenoidectomy operation. The subjects were children of both sexes ranging in age from 6 to 14. The method of evaluating the subject's adjustment to the stress situation was presented. The total group of 26 was divided into "adequate" and "less adequate" adjustment groups on the basis of ratings by psychiatrists from a series of observations of the subject's behavior in the total situation. These two groups served as the external criterion of adjustment to stress. A detailed description of the types of behavior shown by each group was also presented. The two groups differed with regard to emotional control, reality and social behavior. Group I, composed of adequately adjusting subjects, showed more control over expression of feelings, were more reality based and were more sociable than the subjects in Group II, who adjusted less adequately. IV. RESULTS The findings on the WISC and on the Rorschach were presented separately, followed by a discussion of the correlations between the test measures derived from each. The general proposition was first tested by examination of the WISC performance. Of the several measures tested, the following scores succeeded in reliably differentiating between adjustment groups: The Full Scale IQ and the Comprehension, Similarities, Vocabulary and Picture Arrangement subtest scores. The subjects in Group II, on the average, scored lower than those of Group I. The relevance of these findings to the assumptions underlying the interpretation of performance on these measures was discussed in relation to the behavior shown while under stress and described by the psychiatrists. Considerable attention was devoted to a discussion of the meaning of the lower IQ found in the less adequately adjusting group. The relation of this finding to the problem of impairment of intellectual functioning under stress was also discussed. The results suggested that the difference in intellectual functioning was at least in part a function of personality traits also contributing to the differences in observed behavior under stress. The remaining subtest scores, as well as the Total Vocabulary Scatter score, were unable to discriminate between adjustment groups. The findings also suggested that the use of the Vocabulary score as a referent point for scatter analysis in children's records be further investigated for validity of interpretation. A similar experiment was done using the Rorschach Test. The measures used in the test of the hypothesis were those scores which have been proposed in general Rorschach theory as giving information on the subject's modes of expression and control of emotions. More specifically, those signs suggested by Klopfer and Kelley as measures of "inner and outer control" and which were included in Davidson's list of adjustment signs were adapted for use in this research. The level of performance on these signs to be expected for the children in this study followed the modifications suggested by Ackerman in her work with the original Davidson list on a group of normal children. These signs were: M>=1; FC + CF + C> c+ Fc + C'; F% 35-60; FC >= CF; FC >= 1; No pure C; and 8+9+10/Rx1OO% 40-60. In addition, a Total Sign Score, based on the sum of the scores on these seven signns was used. Finally, the experience balance was converted into the score M minus Sum C which was also used here. The results of the Rorschach experiment were that of all the signs tested, only one, the FC >= CF sign was able to reliably differentiate between adjustment groups under all conditions. Under particular conditions of time of administration of this test, the sign M >= 1 was also successful in discriminating between groups. The Total Adjustment Score was found to be a reliable indicator of adjustment, but subsequent analysis revealed that this score was almost identical with the FC >= CF score, used alone. Finally, the F% score was noted to approach significance in its ability to differentiate between groups. The remaining Rorschach measures tested failed to discriminate between the two adjustment groups. These findings were discussed in relation to the assumptions underlying the interpretation of these Rorschach signs and in relation to the manifest behavior shown by the subjects under stress. It was considered that the present findings were in confirmation of the general assumptions regarding the FC:CF ratio as an index of maturity of emotional expression and control and the production of M as a sign of a capacity for delay of impulsive activity. These findings were consistent with other experimental investigations of the role of form in Rorschach responses where form and some other determinant are used in combination. The results further indicated that it was possible to find correlations between single signs or ratios and behavior. A study of the intercorrelations between the factors on the WISC and on the Rorschach found to be reliable indicators of adjustment to stress revealed several significant relationships. The FC:CF ratio on the Rorschach showed a moderately high positive correlation with both Comprehension and Vocabulary on the WISC. The M sign on the Rorschach also showed moderate correlations with these two subtests as well as with the Full Scale IQ. All other correlations failed to give evidence of reliable relationships. Conclusions were drawn from these data relevant to the problem of interpretation posed by the finding of a lower IQ in the less adequately adjusting group. In addition, a conclusion was made that the performance on these factors from the two tests reflected similar aspects of personality functioning. V. CONCLUSIONS Several conclusions were drawn from this research study. The results, in general, were in confirmation of the general hypothesis that performance on psychological tests can be used to differentiate between groups of children who differ in their adjustment to a situation of stress. The particular methodology used in the evaluation of adjustment was thought to have contributed a great deal to the understanding of the test measures which were found to be reliable indicators of adjustment. The variation in emotional and social behavior shown by these children was shown to be related to their performance on the tests and this relationship was seen to be along the lines generally hypothesized for several of the test measures. The difference in functioning intelligence between the groups was concluded to be in part an effect of temperamental factors also contributing to differences in adjustment to stress shown by the two groups of subjects. The finding of a lower performance on the Comprehension, Similarities, Vocabulary and Picture Arrangement subtests by the group of subjects who showed less control over emotional behavior, poorer reality judgment and less sociable behavior was concluded to be evidence in confirmation of the assumption that these personality traits are important determiners of performance on these tests. A similar conclusion was reached with regard to the Rorschach results, as being confirmatory of the clinical assumptions with regard to the two measures derived from this test as being correlated with the subject's capacity for mature affective expression (FC:CF) and an inner resource for delay of immediate gratification (M). The present investigation revealed two major areas for further research. These results strongly suggest further study of the validity of the use of the Vocabulary score as a point of reference for scatter analysis in children's records. Further research is also indicated to explore the relation between the temperamental traits found here to contribute to poor adjustment to stress and the role of symbolic behavior in adjustment

Sufficient Covariate, Propensity Variable and Doubly Robust Estimation

Statistical causal inference from observational studies often requires adjustment for a possibly multi-dimensional variable, where dimension reduction is crucial. The propensity score, first introduced by Rosenbaum and Rubin, is a popular approach to such reduction. We address causal inference within Dawid's decision-theoretic framework, where it is essential to pay attention to sufficient covariates and their properties. We examine the role of a propensity variable in a normal linear model. We investigate both population-based and sample-based linear regressions, with adjustments for a multivariate covariate and for a propensity variable. In addition, we study the augmented inverse probability weighted estimator, involving a combination of a response model and a propensity model. In a linear regression with homoscedasticity, a propensity variable is proved to provide the same estimated causal effect as multivariate adjustment. An estimated propensity variable may, but need not, yield better precision than the true propensity variable. The augmented inverse probability weighted estimator is doubly robust and can improve precision if the propensity model is correctly specified

Sediment Starvation from Dams in the Lower Mekong River Basin: Magnitude of the Effect and Potential Mitigation Opportunities

Source: ICHE Conference Archive - https://mdi-de.baw.de/icheArchive

The cell cycle regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb.

Overexpression of the oncogene MYBL2 (B-Myb) is associated with increased cell proliferation and serves as a marker of poor prognosis in cancer. However, the mechanism by which B-Myb alters the cell cycle is not fully understood. In proliferating cells, B-Myb interacts with the MuvB core complex including LIN9, LIN37, LIN52, RBBP4, and LIN54, forming the MMB (Myb-MuvB) complex, and promotes transcription of genes required for mitosis. Alternatively, the MuvB core interacts with Rb-like protein p130 and E2F4-DP1 to form the DREAM complex that mediates global repression of cell cycle genes in G0/G1, including a subset of MMB target genes. Here, we show that overexpression of B-Myb disrupts the DREAM complex in human cells, and this activity depends on the intact MuvB-binding domain in B-Myb. Furthermore, we found that B-Myb regulates the protein expression levels of the MuvB core subunit LIN52, a key adapter for assembly of both the DREAM and MMB complexes, by a mechanism that requires S28 phosphorylation site in LIN52. Given that high expression of B-Myb correlates with global loss of repression of DREAM target genes in breast and ovarian cancer, our findings offer mechanistic insights for aggressiveness of cancers with MYBL2 amplification, and establish the rationale for targeting B-Myb to restore cell cycle control

Clinical impact of double protease inhibitor boosting with Lopinavir/Ritonavir and Amprenavir as part of salvage antiretroviral therapy

Purpose: Double protease inhibitor (PI) boosting is being explored as a new strategy in salvage antiretroviral (ARV) therapy. However, if a negative drug interaction leads to decreased drug levels of either or both PIs, double PI boosting could lead to decreased virologic response. A negative drug interaction has been described between amprenavir (APV) and lopinavir/ritonavir (LPV/r). This observational cohort study assessed the virologic impact of the addition of APV to a salvage ARV regimen, which also contains LPV/r, compared to a regimen containing LPV/r alone. Method: Patients initiated on a salvage ARV regimen that included LPV/r obtained from the expanded access program in Toronto, Canada, were evaluated. APV (600-1,200 mg bid) was added at the discretion of the treating physician. Results: Using multivariate Cox proportional hazards models, we found that the addition of APV to a LPV/r-containing salvage regimen was not significantly associated with time to virologic suppression (< 50 copies/mL; adjusted hazard ratio [HR] = 0.75, p = .12) or with time to virologic rebound (adjusted HR = 1.46, p = .34). Those patients who received higher doses of APV had an increased chance of virologic suppression (p = .03). In a subset of 27 patients, the median LPV Ctrough was significantly lower in patients receiving APV (p = .04), and the median APV Ctrough was reduced compared to reported controls. Conclusion: Our data do not support an additional benefit in virologic reduction of double boosting with APV and LPV/r relative to LPV/r alone in salvage ARV therapy. Our study's limitations include its retrospective nature and the imbalance between the two groups potentially confounding the results. Although these factors were adjusted for in the multivariate analysis, a prospective randomized controlled trial is warranted to confirm our findings

Prospective Evaluation of Doppler Sonography to Detect the Twinkling Artifact Versus Unenhanced Computed Tomography for Identifying Urinary Tract Calculi

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135595/1/jum201231101619.pd

Ariel - Volume 9 Number 6

Executive Editor Seth B. Paul Associate Editor Warren J. Ventriglia Business Manager Fredric Jay Matlin University News John Patrick Welch World News George Robert Coar Editorials Editor Steve Levine Features Mark Rubin Sports Editor Eli Saleeby Photo Editor Ken Buckwalter Circulation Victor Onufreiczuk Lee Wugofski Graphics and Art Steve Hulkower Commons Editor Brenda Peterso

Zircon dissolution in a ductile shear zone, Monte Rosa granite gneiss, northern Italy

The sizes, distributions and shapes of zircon grains within variably deformed granite gneiss from the western Alps have been studied. Zircon shows numerous indicators of a metamorphic response in both the host gneiss and a 5 cm wide continuous ductile shear zone, within which the zircon grain sizes range from &#60;1 µm to &#62;50 µm. However, the very fine grain sizes are virtually absent from grain boundaries. Within this zone, zircons consistently have more rounded and embayed margins, which are interpreted as evidence of dissolution in response to fluid influx during shearing. Zircons are preferentially located near metamorphic muscovite in both the host gneiss and the shear zone and tend to show the poorest crystal shape, indicating that fluids linked to the formation and presence of muscovite may enhance both the crystallization of zircon and its subsequent dissolution. Larger zircon crystals typically show a brittle response to deformation when adjacent to phyllosilicates, with fractures consistently perpendicular to the (001) mica cleavage. The variety of metamorphic behaviour observed for zircon indicates that it may be highly reactive in sub-solidus mid-crustal metamorphic environments

Anomalous thermal conductivity and local temperature distribution on harmonic Fibonacci chains

The harmonic Fibonacci chain, which is one of a quasiperiodic chain constructed with a recursion relation, has a singular continuous frequency-spectrum and critical eigenstates. The validity of the Fourier law is examined for the harmonic Fibonacci chain with stochastic heat baths at both ends by investigating the system size N dependence of the heat current J and the local temperature distribution. It is shown that J asymptotically behaves as (ln N)^{-1} and the local temperature strongly oscillates along the chain. These results indicate that the Fourier law does not hold on the harmonic Fibonacci chain. Furthermore the local temperature exhibits two different distribution according to the generation of the Fibonacci chain, i.e., the local temperature distribution does not have a definite form in the thermodynamic limit. The relations between N-dependence of J and the frequency-spectrum, and between the local temperature and critical eigenstates are discussed.Comment: 10 pages, 4 figures, submitted to J. Phys.: Cond. Ma

Hall Effect in the coma of 67P/Churyumov-Gerasimenko

Magnetohydrodynamics simulations have been carried out in studying the solar wind and cometary plasma interactions for decades. Various plasma boundaries have been simulated and compared well with observations for comet 1P/Halley. The Rosetta mission, which studies comet 67P/Churyumov-Gerasimenko, challenges our understanding of the solar wind and comet interactions. The Rosetta Plasma Consortium observed regions of very weak magnetic field outside the predicted diamagnetic cavity. In this paper, we simulate the inner coma with the Hall magnetohydrodynamics equations and show that the Hall effect is important in the inner coma environment. The magnetic field topology becomes complex and magnetic reconnection occurs on the dayside when the Hall effect is taken into account. The magnetic reconnection on the dayside can generate weak magnetic filed regions outside the global diamagnetic cavity, which may explain the Rosetta Plasma Consortium observations. We conclude that the substantial change in the inner coma environment is due to the fact that the ion inertial length (or gyro radius) is not much smaller than the size of the diamagnetic cavity.Comment: 23 pages, 6 figur