179 research outputs found
Public attitudes in England towards the sharing of personal data following a mass casualty incident : a cross-sectional study
Objectives: To assess public attitudes towards data sharing to facilitate a mental health screening programme for people caught up in a mass casualty incident.
Design: Two, identical, cross-sectional, online surveys, using quotas to ensure demographic representativeness of people aged 18–65 years in England. Participants were randomly allocated to consider a scenario in which they witness a terrorism-related radiation incident or mass shooting, after which a police officer records their contact details.
Setting: Participants were drawn from an online panel maintained by a market research company. Surveys were conducted before and immediately after a series of terrorist attacks and a large tower block fire occurred in England.
Participants: One thousand people aged 18–65 years participated in each survey.
Main outcome measures: Three questions asking participants if it would be acceptable for police to share their contact details, without asking first, with ‘a health-related government organisation, so they can send you a questionnaire to find out if you might benefit from extra care or support’, ‘a specialist NHS team, to provide you with information about ways to get support for any physical or mental health issues’ and ‘your GP, so they can check how you are doing’.
Results: A minority of participants reported that it would be definitely not acceptable for their details to be shared with the government organisation (n=259, 13.0%), the National Health Service (NHS) (n=141, 7.1%) and their general practitioner (GP) (n=166, 8.3%). There was a small, but significant increase in acceptability for the radiation incident compared with the mass shooting. No major differences were observed between the preincident and postincident surveys.
Conclusions: Although most people believe it is acceptable for their details to be shared in order to facilitate a mental health response to a major incident, care must be taken to communicate with those affected about how their information will be used
Quantum diffraction and interference of spatially correlated photon pairs generated by spontaneous parametric down-conversion
We demonstrate one- and two-photon diffraction and interference experiments
utilizing parametric down-converted photon pairs (biphotons) and a transmission
grating. With two-photon detection, the biphoton exhibits a
diffraction-interference pattern equivalent to that of an effective single
particle that is associated with half the wavelength of the constituent
photons. With one-photon detection, however no diffraction-interference pattern
is observed. We show that these phenomena originate from the spatial quantum
correlation between the down-converted photons.Comment: 4 pages, 5 figure
Spectroscopy by frequency entangled photon pairs
Quantum spectroscopy was performed using the frequency-entangled broadband
photon pairs generated by spontaneous parametric down-conversion. An absorptive
sample was placed in front of the idler photon detector, and the frequency of
signal photons was resolved by a diffraction grating. The absorption spectrum
of the sample was measured by counting the coincidences, and the result is in
agreement with the one measured by a conventional spectrophotometer with a
classical light source.Comment: 11 pages, 5 figures, to be published in Phys. Lett.
Reconstruction of the Dark Energy equation of state
One of the main challenges of modern cosmology is to investigate the nature
of dark energy in our Universe. The properties of such a component are normally
summarised as a perfect fluid with a (potentially) time-dependent
equation-of-state parameter . We investigate the evolution of this
parameter with redshift by performing a Bayesian analysis of current
cosmological observations. We model the temporal evolution as piecewise linear
in redshift between `nodes', whose -values and redshifts are allowed to
vary. The optimal number of nodes is chosen by the Bayesian evidence. In this
way, we can both determine the complexity supported by current data and locate
any features present in . We compare this node-based reconstruction with
some previously well-studied parameterisations: the Chevallier-Polarski-Linder
(CPL), the Jassal-Bagla-Padmanabhan (JBP) and the Felice-Nesseris-Tsujikawa
(FNT). By comparing the Bayesian evidence for all of these models we find an
indication towards possible time-dependence in the dark energy
equation-of-state. It is also worth noting that the CPL and JBP models are
strongly disfavoured, whilst the FNT is just significantly disfavoured, when
compared to a simple cosmological constant . We find that our node-based
reconstruction model is slightly disfavoured with respect to the CDM
model.Comment: 17 pages, 5 figures, minor correction
Infinite systems of non-colliding generalized meanders and Riemann-Liouville differintegrals
Yor's generalized meander is a temporally inhomogeneous modification of the
-dimensional Bessel process with , in which the
inhomogeneity is indexed by . We introduce the
non-colliding particle systems of the generalized meanders and prove that they
are the Pfaffian processes, in the sense that any multitime correlation
function is given by a Pfaffian. In the infinite particle limit, we show that
the elements of matrix kernels of the obtained infinite Pfaffian processes are
generally expressed by the Riemann-Liouville differintegrals of functions
comprising the Bessel functions used in the fractional calculus,
where orders of differintegration are determined by . As special
cases of the two parameters , the present infinite systems
include the quaternion determinantal processes studied by Forrester, Nagao and
Honner and by Nagao, which exhibit the temporal transitions between the
universality classes of random matrix theory.Comment: LaTeX, 35 pages, v3: The argument given in Section 3.2 was
simplified. Minor corrections were mad
Observational constraints on conformal time symmetry, missing matter and double dark energy
The current concordance model of cosmology is dominated by two mysterious
ingredients: dark matter and dark energy. In this paper, we explore the
possibility that, in fact, there exist two dark-energy components: the
cosmological constant , with equation-of-state parameter
, and a `missing matter' component with , which we
introduce here to allow the evolution of the universal scale factor as a
function of conformal time to exhibit a symmetry that relates the big bang to
the future conformal singularity, such as in Penrose's conformal cyclic
cosmology. Using recent cosmological observations, we constrain the present-day
energy density of missing matter to be . This is
consistent with the standard CDM model, but constraints on the energy
densities of all the components are considerably broadened by the introduction
of missing matter; significant relative probability exists even for
, and so the presence of a missing matter component
cannot be ruled out. As a result, a Bayesian model selection analysis only
slightly disfavours its introduction by 1.1 log-units of evidence. Foregoing
our symmetry requirement on the conformal time evolution of the universe, we
extend our analysis by allowing to be a free parameter. For this more
generic `double dark energy' model, we find and
, which is again consistent with the standard
CDM model, although once more the posterior distributions are
sufficiently broad that the existence of a second dark-energy component cannot
be ruled out. The model including the second dark energy component also has an
equivalent Bayesian evidence to CDM, within the estimation error, and
is indistinguishable according to the Jeffreys guideline.Comment: Revised version emphasising a different version of the underlying
symmetry, as published in JCA
Tidal Dwarf Galaxies at Intermediate Redshifts
We present the first attempt at measuring the production rate of tidal dwarf
galaxies (TDGs) and estimating their contribution to the overall dwarf
population. Using HST/ACS deep imaging data from GOODS and GEMS surveys in
conjunction with photometric redshifts from COMBO-17 survey, we performed a
morphological analysis for a sample of merging/interacting galaxies in the
Extended Chandra Deep Field South and identified tidal dwarf candidates in the
rest-frame optical bands. We estimated a production rate about 1.4 {\times}
10^{-5} per Gyr per comoving volume for long-lived TDGs with stellar mass 3
{\times} 10^{8-9} solar mass at 0.5<z<1.1. Together with galaxy merger rates
and TDG survival rate from the literature, our results suggest that only a
marginal fraction (less than 10%) of dwarf galaxies in the local universe could
be tidally-originated. TDGs in our sample are on average bluer than their host
galaxies in the optical. Stellar population modelling of optical to
near-infrared spectral energy distributions (SEDs) for two TDGs favors a burst
component with age 400/200 Myr and stellar mass 40%/26% of the total,
indicating that a young stellar population newly formed in TDGs. This is
consistent with the episodic star formation histories found for nearby TDGs.Comment: 9 pages, 5 figures, Accepted for publication in Astrophysics & Space
Scienc
Use of Nonantiretroviral Medications That May Impact Neurocognition: Patterns and Predictors in a Large, Long-Term HIV Cohort Study
Background: Neurocognitive impairment is a frequent and often disabling comorbidity of HIV infection. In addition to antiretroviral therapies, individuals with HIV infection may commonly use nonantiretroviral medications that are known to cause neurocognitive adverse effects (NC-AE). The contribution of NC-AE to neurocognitive impairment is rarely considered in the context of HIV and could explain part of the variability in neurocognitive performance among individuals with HIV. Setting: Women’s Interagency HIV Study, a prospective, multisite, observational study of US women with and without HIV. Methods: After a literature review, 79 medications (excluding statins) with NC-AE were identified and reported by Women’s Interagency HIV Study participants. We examined factors associated with self-reported use of these medications over a 10-year period. Generalized estimating equations for binary outcomes were used to assess sociodemographic, behavioral, and clinical characteristics associated with NC-AE medication use. Results: Three thousand three hundred women (71% with HIV) and data from ~42,000 visits were studied. HIV infection was associated with NC-AE medication use (odds ratio = 1.52; 95% confidence interval: 1.35 to 1.71). After adjustment for HIV infection status, other predictors of NC-AE medication use included having health insurance, elevated depressive symptoms, prior clinical AIDS, noninjection recreational drug use, and an annual household income of <$12,000 (Ps < 0.004). NC-AE medication use was less likely among women who drank 1–7 or 8–12 alcoholic drinks/week (vs. abstaining) (P < 0.04). Conclusions: HIV infection was associated with NC-AE medication use, which may influence determinations of HIV-associated neurocognitive impairment. Providers should consider the impact of NC-AE medications when evaluating patients with HIV and concurrent neurocognitive symptoms
Degree of Polypharmacy and Cognitive Function in Older Women with HIV
The number of people with HIV (PWH) experiencing age-associated comorbidities including those treated with medications and cognitive impairment is increasing. We examined associations between polypharmacy and cognition in older women with HIV (WWH) given their vulnerability to this comorbidity. Cross-sectional analysis capitalizing on Women's Interagency HIV Study data collected between 2014 and 2017. WWH meeting the following criteria were analyzed: age ≥50 years; availability of self-reported non-antiretroviral therapy (ART) medications data; and neuropsychological data. The number of non-ART medications used regularly in the prior 6 months was summed. Polypharmacy was categorized as none/low (0-4), moderate (5-9), or severe (≥10). Multivariable linear regression analyses examined polypharmacy-cognition (T-score) associations in the total sample and among virally suppressed (VS; < 20 copies/mL)-WWH after covariate adjustment for enrollment site, income, depressive symptoms, substance use (smoking, heavy alcohol, marijuana, crack, cocaine, and/or heroin), the Veterans Aging Cohort Study index (indicators of HIV disease and organ system function, hepatitis C virus serostatus), ART use, nadir CD4 count, and specific ART drugs (efavirenz, integrase inhibitors). We included 637 women (median age = 55 years; 72% Black). Ninety-four percent reported ART use in the past 6 months and 75% had HIV RNA <20 copies/mL. Comorbidity prevalence was high (61% hypertension; 26% diabetes). Moderate and severe polypharmacy in WWH were 34% and 24%. In WWH, severe polypharmacy was associated with poorer executive function (p = .007) and processing speed (p = .01). The same pattern of findings remained among VS-WWH. Moderate polypharmacy was not associated with cognition. Moderate and severe polypharmacy were common and associated with poorer executive function and processing speed in WWH. Severe polypharmacy may be a major contributor to the persistence of domain-specific cognitive complications in older WWH above and beyond the conditions that these medications are used to treat
Weight and Body Mass Index Change after Switching to Integrase Inhibitors or Tenofovir Alafenamide among Women Living with HIV
Weight and body mass index (BMI) change was assessed among women after switch to integrase inhibitors (INSTIs) and/or tenofovir alafenamide (TAF). From 2006 to 2019, 1,458 women living with HIV enrolled in the Women's Interagency HIV Study and on antiretroviral therapy (ART) with ≥1 study visit before and after switching to INSTIs and/or TAF were included. Weight and BMI were compared pre- and postswitch to INSTI (by class and type) and/or TAF using multivariable linear mixed effects models; all models were also stratified by preswitch presence or absence of obesity (BMI ≥30 vs. <30 kg/m2). Mean age preswitch was 47 ± 6 years, 64% were black, mean CD4 = 475 ± 201 cells/mm3, 56% had HIV RNA <200 copies/mL, 36% switched to TAF but not INSTI, 60% to INSTI but not TAF, and 3.5% to TAF+INSTI. Time from pre- to postswitch was 12.8 ± 11.8 months. The INSTI-only group but not TAF groups had small but significant increases in weight and BMI: mean 79.2-80.6 kg and 30.2-30.7 kg/m2, p's < .001, respectively, with congruent findings by INSTI type (p's ≤ .01). In stratified (preswitch BMI) analyses, only nonobese subgroups experienced increases in weight and BMI across all ART treatment groups (p's < .05). Significant, although small-to-medium, increases in weight and BMI occurred among nonobese women who switched to INSTIs and/or TAF over short follow-up. Given long-term health consequences of obesity particularly as a low-grade inflammatory condition, identifying women at highest risk of ART-associated weight gain is imperative
- …