3 research outputs found
Kolonizacija vankomicin rezistentnom bakterijom Enterococcus faecium i Clostridium difficile infekcija u hematoloŔke bolesnice
Vancomycin-resistant enterococci (VRE), especially Enterococcus faecium, have emerged as significant nosocomial pathogens and patients with impaired host defenses are at a particular risk of VRE infection. The most common occurrence is asymptomatic colonization of the gastrointestinal tract that can persist for a long time and serve as a reservoir for transmission of VRE to other patients. We present a case of a patient who was diagnosed with acute myelogenous leukemia and suffered from bone marrow aplasia following induction therapy. The patient received prolonged broad-spectrum antimicrobial therapy. During hospital stay, the patient developed Clostridium difficile infection (CDI) and was found to be colonized with a strain of Enterococcus faecium resistant to vancomycin during therapy for CDI. This case also highlights the role of risk factors that could contribute to development of resistance, particularly CDI. Early detection of VRE colonization or infection is a crucial component in hospital program designed to prevent transmission of nosocomial infections. Surveillance cultures of such patients should be mandatory.Vankomicin-rezistentni enterokoki (VRE), naroÄito Enterococcus faecium, spadaju meÄu najznaÄajnije bolniÄke patogene, pri Äemu su naroÄito ugroženi bolesnici oslabljenog imunosnog statusa. Pritom je najÄeÅ”Äa pojava asimptomatske kolonizacije probavnog sustava koja može ustrajati duže vremena i biti rezervoar za Å”irenje VRE na ostale bolesnike. Donosimo prikaz sluÄaja bolesnice s dijagnozom akutne mijelomonocitne leukemije praÄene aplazijom koÅ”tane srži nakon indukcijske terapije. Bolesnica je lijeÄena antibioticima Å”irokog spektra. Tijekom hospitalizacije u bolesnice se razvila infekcija bakterijom Clostridium difficile (CDI) uz dokazanu kolonizaciju sojem Enterococcus faecium rezistentnog na vankomicin tijekom terapije zbog CDI. TakoÄer su prikazani Äimbenici rizika koji su u navedenom sluÄaju mogli poslužiti kao potencijalni okidaÄ za razvoj rezistencije, s osobitim naglaskom na CDI. Rano otkrivanje kolonizacije ili infekcije navedenim sojevima je iznimno znaÄajan Äimbenik bolniÄkog programa za prevenciju Å”irenja bolniÄkih infekcija. MikrobioloÅ”ki nadzor uzimanjem nadzornih kultura mora biti obvezni dio protokola pri hospitalizaciji takvih bolesnika
KliniÄki prikaz genitourinarne tuberkuloze sa sumnjom na abdominalnu neoplazmu
Genital tuberculosis is a rare and unexpected disease in European countries including
Croatia. Diagnosis of female genital tract tuberculosis is challenging and is rarely pin-pointed
by clinical symptoms because of their low specificity. The authors decided to present a case of genitourinary
tuberculosis in a young, immunocompetent fertile woman with high clinical suspicion of
abdominal tumor mass. Although considered a desease of the past, rare clinical presentation of genital
tuberculosis should be expected and taken into account.Genitalna tuberkuloza rijetka je i neoÄekivana bolest u zemljama Europske unije ukljuÄujuÄi i Hrvatsku. Postavljanje
dijagnoze tuberkuloze genitalnog sustava otežano je nespecifiÄnim simptomima. Prikazujemo sluÄaj genitourinarne
tuberkuloze kod mlade imunokompetentne žene generativne dobi gdje je kliniÄka dijagnoza upuÄivala na abdominalnu
neoplazmu. U vremenu velikih druÅ”tvenih promjena prisutnih posljednjih godina rijetke kliniÄke prezentacije tuberkuloze i
dalje su moguÄe kao diferencijalna dijagnoza
Comparison of the novel Uroquattro HB&Lā¢ system and classical phenotypic method for rapid screening of multidrug-resistant organism colonization at the University Hospital Centre Split, Croatia
Uvod: Infekcije uzrokovane viÅ”estruko otpornim organizmima (MDRO) se teÅ”ko lijeÄe i Äesto imaju nepovoljan ishod za bolesnika. BuduÄi da infekciji najÄeÅ”Äe prethodi kolonizacija, rana identifikacija koloniziranih bolesnika je neophodna u prevenciji nastanka infekcije. Za probir MDRO najÄeÅ”Äe se koriste kultivacijske metode kojima vrijeme potrebno za izdavanje nalaza (TAT) iznosi od 48 do 72 h.
Cilj ove studije bio je usporediti rezultate nove, brze, poluautomatske metode za detekciju MDRO (HB&L Uroquattro, Alifax) sa standardnom kultivacijom na selektivnim podlogama.
Metode/materijali: Tijekom dva nasumiÄno odabrana dana, bolesnicima hospitaliziranima u KliniÄkom bolniÄkom centru Split, uzorkovano je ukupno 21 aksilarnih, 19 rektalnih te 20 briseva vestibuluma nosa. Svaki obrisak je prikupljen u duplikatu, jedan za kultivacijsku, a drugi za brzu poluatomatsku metodu. Brisevi su kultivirani i MDRO izolati identificirani na selektivnim podlogama (Chromagar MRSA i Chromagar ESBL) prema standardnom laboratorijskom protokolu. Nova Alifaxova metoda je provedena prema uputama proizvoÄaÄa.
Rezultati: U usporedbi s klasiÄnom metodom, TAT nove metode je bio znaÄajno kraÄi (6,5 h). KlasiÄnom metodom je na Chromagar ESBL selektivnom mediju izolirano 10 sojeva koji stvaraju Ć-laktamaze proÅ”irenog spektra (ESBL) iz 10 razliÄitih rektalnih uzoraka. Isti uzorci su bili pozitivni na prisustvo ESBL- producirajuÄih bakterija brzom Alifaxovom metodom. Kultivacijom na selektivnom Chromagar MRSA mediju i brzom metodom otkriveno je 11 uzoraka pozitivnih na prisustvo MDRO.
ZakljuÄak: Visoki stupanj podudarnosti otkrivanja pozitivnih i negativnih uzoraka dobiven klasiÄnom i novom metodom, kao i znaÄajno skraÄivanje TAT-a novom metodom je ohrabrujuÄi. BuduÄi je studija provedena na relativno malom uzorku, potrebno je istraživanje proÅ”iriti na veÄi broj ispitanika.Background. Infections caused by multidrug-resistant organisms (MDRO) are difficult to treat and associated with poor outcomes for patients. Therefore, early identification and management of colonization are essential as first steps in infection prevention. Culture-based methods have been widely used for MDRO screening. The turnaround time (TAT) for the identification of carriers varies between 48-72 h with this method. The aim of our study was to compare the performance of the new rapid semiautomatic method for detection of MDRO (HB&L Uroquattro, Alifax) with standard cultivation on selective media.
Methods. Twenty-one axillary, 20 nose and 19 rectal swabs were taken in duplicate on two selected days at the University Hospital Centre Split, Croatia. Swabs were cultivated and MDRO isolates were identified on selective media (Chromagar MRSA and Chromagar ESBL) according to the standard operating procedure. Novel Alifax method was performed according to manufacturerās instructions.
Results. TAT for the new method was significantly lower (6.5 h) in comparison to the classical method. With classical method, 10 extended spectrum Ć-lactamases (ESBL) producing strains from 10 different rectal specimens were isolated on Chromagar ESBL media. Exactly the same specimens were positive for the presence of ESBL-producing bacteria by rapid Alifax method. On selective Chromagar MRSA media, 11 MDRO were isolated, while rapid method detected 11 MDRO from the same specimens.
Conclusions. High concordance of positive and negative results obtained with classical and rapid method is encouraging. However, our study was performed on a small sample size and further research with larger sample size is needed