Introduction: Conflict Resolution and Social Justice

A daunting obstacle to clarity in formulating ideas about conflict resolution and social justice is the fact that each of these terms has multiple meanings. There is widespread recognition that social justice is a multivalent phrase. Commentators since Aristotle have written of distributive, restitutive, retributive, procedural, and relational justice, and each of these types has been further subdivided to reflect differences in social philosophy and in common usage. Less well recognized is the ambiguity of conflict resolution, a term that refers to a mélange of theories and practices that, although interrelated, do not constitute a cleanly demarcated and coherently defined whole. To name a few large subdivisions in this evolving field, we are accustomed to speak of alternative dispute resolution, principled negotiation, relational transformation, public dispute resolution, analytical conflict resolution, and individual or communal reconciliation processes

Will the President be able to resolve the Middle East crisis?

In this lecture in the "Israel and Palestine" Looking Ahead Twenty-five Years series, Richard L. Rubenstein offers a profound reflection on the political and religious developments of Israel and Palestine and the moral dilemmas that result from it

Changing Demographics and the Middle East

In this lecture in the Israel and Palestine "Looking Ahead Twenty-five Years" series, Dr. Richard L. Rubenstein discusses the changes in the demographics and the significance of the growth of Islam in Europe

Responsibility for Peacemaking in the Context of Structural Violence

“They cry Peace, Peace, but there is no peace.” Jeremiah’s complaint resounds loudly in a period in which many of the most intractable social conflicts are products not just of prejudice, malice, or misunderstanding, but also of the normal operations of structurally violent systems. This essay begins by outlining and modifying the theory of structural violence originally presented by Johan Galtung. It goes on to describe several types of conflict-generating systems, including the capitalist economy that produces crime and mass incarceration and the neo-empire that produces terrorism and the “war on terror.” Finally, it inquires into the responsibility of would-be conflict resolvers for system transformation, stressing the need for new forms of conflict resolution theory and practice, and suggesting several processes that might help to satisfy this need

Technology, Unemployment and Genocide

The impact of technology on the processes of production affects every aspect of American life, and most especially the long-range employment prospects of the American worker

Conflict Resolution and Distributive Justice: Reflections on the Burton-Laue Debate

Excerpt From its inception, the field of conflict resolution has appealed strongly to practitioners, researchers, and theorists interested in social betterment. Most conflict resolvers would probably agree that their efforts are motivated, at least in part, by the conception of a Good (or at least a Better) Society considerably less violent and contentious, more peaceful and cooperative, than the existing social order. Many would also affirm that in order to reach this goal, the sources of violence and contention, which include cultural norms sanctioning or glorifying violence, invidious and discriminatory isms (racism, sexism, etc.), gross socioeconomic and political inequities, and over-reliance on formal, adversarial decision-making procedures need to be eliminated or, at least, mitigated. And many would assert, in addition, that the methods of making these changes should be consistent, so far as possible, with the aims sought to be achieved: that is, they should rely on nonviolent conflict resolution.

Activation of G protein-coupled receptors entails cysteine modulation of agonist binding

The increase of the affinity of agonists with an increase in pH and experiments using thiol-specific reagents indicate that G protein-coupled receptors contain an ionizable cysteine residue at the ligand binding site. Since treatment of receptors with reducing agents produces functional activation and potentiates agonist stimulation, it is likely that this free sulfhydryl modulates receptor activation. We have derived a two-state acid-base model for cysteine modulation of ligand binding which leads to a description of ligand efficacy. We have shown that pH-dependent binding of agonists is closely correlated with measurements of ligand efficacy at the 5-HT2A receptor. In general, efficacy is determined by the preference of a ligand for the base of the receptor. Efficacy may also be described in thermodynamic terms as the coupling free energy involving a ligand and the acid and base states of the receptor. Molecular modeling of the third transmembrane domain of the 5-HT2A receptor, which contains a conserved cysteine, shows that efficacy is determined by the difference between the electrostatic interaction energies of a ligand with the acid and base forms of the receptor model. The difference in interaction energy between the two forms of cysteine makes the largest contribution to this electrostatic interaction energy difference. Therefore, the cysteine makes the largest contribution to ligand efficacy. Using this approach, we can distinquish between the efficacies of agonists with varying molecular structures and account for the differences between the properties of agonists and antagonists

Genocide and the Modern Age: Etiology and Case Studies of Mass Death

https://surface.syr.edu/books/1023/thumbnail.jp

Differential expression of interferon responsive genes in rodent models of transmissible spongiform encephalopathy disease

BACKGROUND: The pathological hallmarks of transmissible spongiform encephalopathy (TSE) diseases are the deposition of a misfolded form of a host-encoded protein (PrP(res)), marked astrocytosis, microglial activation and spongiosis. The development of powerful gene based technologies has permitted increased levels of pro-inflammatory cytokines to be demonstrated. However, due to the use of assays of differing sensitivities and typically the analysis of a single model system it remained unclear whether this was a general feature of these diseases or to what extent different model systems and routes of infection influenced the relative levels of expression. Similarly, it was not clear whether the elevated levels of cytokines observed in the brain were accompanied by similar increases in other tissues that accumulate PrP(res), such as the spleen. RESULTS: The level of expression of the three interferon responsive genes, Eif2ak2, 2'5'-OAS, and Mx2, was measured in the brains of Syrian hamsters infected with scrapie 263K, VM mice infected with bovine spongiform encephalopathy and C57BL/6 mice infected with the scrapie strain ME7. Glial fibrillary acidic expression confirmed the occurrence of astrocytosis in all models. When infected intracranially all three models showed a similar pattern of increased expression of the interferon responsive genes at the onset of clinical symptoms. At the terminal stage of the disease the level and pattern of expression of the three genes was mostly unchanged in the mouse models. In contrast, in hamsters infected by either the intracranial or intraperitoneal routes, both the level of expression and the expression of the three genes relative to one another was altered. Increased interferon responsive gene expression was not observed in a transgenic mouse model of Alzheimer's disease or the spleens of C57BL/6 mice infected with ME7. Concurrent increases in TNFα, TNFR1, Fas/ApoI receptor, and caspase 8 expression in ME7 infected C57BL/6 mice were observed. CONCLUSION: The identification of increased interferon responsive gene expression in the brains of three rodent models of TSE disease at two different stages of disease progression suggest that this may be a general feature of the disease in rodents. In addition, it was determined that the increased interferon responsive gene expression was confined to the CNS and that the TSE model system and the route of infection influenced the pattern and extent of the increased expression. The concurrent increase in initiators of Eif2ak2 mediated apoptotic pathways in C57BL/6 mice infected with ME7 suggested one mechanism by which increased interferon responsive gene expression may enhance disease progression