Sexual Risk Behavior in HIV-Uninfected Pregnant Women in Western Uganda

Our aim was to identify sexual risk behavior among HIV-negative pregnant women in Kabarole District, Uganda, by conducting a cross-sectional study among 1610 women within three healthcare settings. One in six women engaged in HIV-specific risk behaviors including multiple sexual partners or alcohol abuse; 80% of the pregnant women reported to generally abstain from using condoms. In multivariate analysis, predictors of sexual risk behavior included being a client of the public health facilities as compared to the private facility (AOR 3.6 and 4.8, p < 0.001), being single, widowed or divorced or not cohabiting with the partner (AOR 4.7 and 2.3, p < 0.001), as well as higher household wealth (AOR 1.8, p < 0.001) and lack of partner status knowledge (AOR 1.6, p = 0.008). Self-estimated risk perception was linked with engagement in HIV-related risk behaviors except for alcohol abuse. Our findings indicate that reducing risky behaviors in pregnancy in order to prevent HIV should be a high-priority public health concern

Premature Infant Care and Feeding

The burden of premature birth is still high worldwide at 10.6% and ranges from 5 to 18% of all babies born. About 80% of these occur in Africa and South Asia. In Sub-Saharan Africa, the burden ranges from 3.4 to 49.4%. In almost all countries, premature birth rates are on increase, which poses a threat to newborn health. Premature babies usually present with complications that hinder their ability to feed. Due to this, premature babies are at risk of insufficient nutrient supply, leading to undernutrition, failure to thrive and early newborn deaths. However, improved newborn feeding can avert these deaths. In line with this noble cause, this chapter focused on care and feeding of premature babies in hospital and home settings, feeding development, feeding difficulties, and growth and development monitoring for premature babies

The incidence of HIV and associated risk factors among pregnant women in Kabarole District, Uganda

Objectives: The study attempted to determine the incidence of HIV among pregnant women in Kabarole District, Uganda, and to identify socio-demographic and behavioral risk factors for seroconversion during pregnancy. Methods: We carried out a retrospective cohort study among women for whom a documented HIV-negative test result from the first pregnancy trimester could be confirmed using available records, and who were HIV-retested in the third trimester or during delivery. In total, 1610 pregnant women from three different healthcare settings took part in the study. We captured the results of repeated HIV tests and conducted semi-structured interviews to explore participants’ socio-demographic characteristics and sexual risk behavior. For HIV incidence rates, we calculated the number of seroconversions per 100 person-years. We used Fisher's exact test to test for potential associations. Penalized maximum likelihood logistic regression and Poisson regression were applied to adjust for potential confounders. Results: The overall HIV incidence rate among participants was 2.9/100 women-years. Among socio-demographic characteristics, the multivariable analysis showed a significant association of marital status with HIV incidence in pregnancy (IRR 8.78, 95%CI [1.13–68.33]). Risky sexual behaviors including higher number of sexual partners in pregnancy (IRR 2.78 [1.30–5.94]), unprotected sex with unknown persons (IRR 14.25 [4.52–44.93]), alcohol abuse (IRR 12.08 [4.18–34.90]) and sex under the influence of drugs or alcohol (IRR 6.33 [1.36–29.49]) were significantly associated with seroconversion in pregnancy (similar results in logistic regression). Conclusions: HIV incidence was three times higher among our pregnant study population compared to the general female population in Uganda. This underlines the importance of HIV prevention and repeat testing during pregnancy. Identified risk groups should be considered for pre-exposure prophylaxis