4 research outputs found
Immunomodulating activity of Celosia argentea Linn aerial parts
Aerial parts of Celosia argentea Linn. (Amaranthaceae) were extracted with 70 % ethanol
and water to produce respective extracts. These extracts were screened for delayed type hypersensitivity
(DTH), neutrophil adhesion test and cyclophosphamide-induced myelosuppression to assess the effect on
immunity in Swiss albino mice at the dose of 50 and 100 mg/kg, i.p. Results showed significant immunomodulating
activity of aqueous extract.Colegio de Farmac茅uticos de la Provincia de Buenos Aire
Effect of Tephrosia purpurea roots extracts on acetic acid induced colitis in mice
Tephrosia purpurea L. (Leguminosae), commonly known as Unhali in Marathi is a copiously
branched perennial herb. Traditionally the roots of this plant are used in the treatment of ulcer and colic
pain. So the present work was undertaken to validate its use in the treatment of ulcerative colitis by using
suitable scientific methods. Shade dried and coarsely powdered roots were subjected to successive extraction
with ethanol and water. The dried extracts (100 and 200 mg/kg) were screened for ulcerative colitis
using the method acetic acid induced ulcerative colitis in mice. Macroscopical study of the colon, level of
myeloperoxidase in colon and histopathology of the colon tissue were studied for the assessment of the activity.
Results showed that aqueous extract was significantly effective in the treatment of ulcerative colitis
at dose of 200 mg/kg. It can be concluded that the polar constituents of T. purpurea L. may be useful in the
treatment of ulcerative colitis.Colegio de Farmac茅uticos de la Provincia de Buenos Aire