Basis set effects on the electron density and spectroscopic properties of CO

The effect of basis set incompleteness on the deformation density of CO is studied by comparing various STO basis sets with a fully numerical (basis-free) result. A triple-zeta s, p basis plus one 3d and one 4f function appears to be practically converged. The convergence characteristics of other properties (Re, De, ωe, μ0, μ1, electric field gradient (EFG)) with respect to basis set size and type are also investigated. The convergence behaviour is similar for these properties and the deformation densities

Living with genital Pain: women's experience of treatment seeking

Female Genital Pain (FGP) is a sexual dysfunction that is difficult to diagnose and treat, which can make treatment seeking a distressing experience. In the present study the lived experience of women with genital pain as explored in order to develop a grounded model of treatment seeking for FGP. A constructivist lived experience perspective underpinned this research. Participants were 26 women with genital pain, specifically vaginismus (n=4) and (n=22). The average age of the participants was 27. Identified motivations for seeking treatment were the belief that they might have an infection, optimistic views about their health or an expectation that relationships include intercourse. Barriers occurred when they normalised or discounted their symptoms or held negative treatment beliefs. Unsurprisingly, the identified barriers were associated with delayed treatment seeking. The women described three agendas for their consultation with a health care professional (HCP) – validation of their symptoms, an informed HCP, and a strong HCP–patient alliance. Agendas that were met played a significant role in decreasing distress. Identified salient survivorship resources were a supportive HCP and personal agency. These resources encouraged consistent treatment seeking. The personal narratives that contributed to more consistent treatment seeking were personal agency, communion, redemption, creating meaning of suffering, positive sexual identity and positive resolution. Identities that were characterised by contamination and negative sexual self-schema were associated with no treatment seeking or delayed treatment seeking. The findings of this study allow HCPs and researchers to better understand the needs of women with genital pain. Furthermore, this research will help guide future research and the development of future initiatives to improve the treatment of genital pain conditions, thus improving the outcomes and quality of life for women with genital pain

Overfitting for Fun and Profit: Instance-Adaptive Data Compression

Neural data compression has been shown to outperform classical methods in terms of $RD$ performance, with results still improving rapidly. At a high level, neural compression is based on an autoencoder that tries to reconstruct the input instance from a (quantized) latent representation, coupled with a prior that is used to losslessly compress these latents. Due to limitations on model capacity and imperfect optimization and generalization, such models will suboptimally compress test data in general. However, one of the great strengths of learned compression is that if the test-time data distribution is known and relatively low-entropy (e.g. a camera watching a static scene, a dash cam in an autonomous car, etc.), the model can easily be finetuned or adapted to this distribution, leading to improved $RD$ performance. In this paper we take this concept to the extreme, adapting the full model to a single video, and sending model updates (quantized and compressed using a parameter-space prior) along with the latent representation. Unlike previous work, we finetune not only the encoder/latents but the entire model, and - during finetuning - take into account both the effect of model quantization and the additional costs incurred by sending the model updates. We evaluate an image compression model on I-frames (sampled at 2 fps) from videos of the Xiph dataset, and demonstrate that full-model adaptation improves $RD$ performance by ~1 dB, with respect to encoder-only finetuning.Comment: Accepted at International Conference on Learning Representations 202

Incidence and survival rate of women with cervical cancer in the Greater Amsterdam area

To evaluate the effect of population-based cervical cancer screening on the occurrence of cervical cancer in The Netherlands, we investigated the incidence and survival of cervical cancer registered by a cancer registry in the Greater Amsterdam area. The incidence rate of squamous cell carcinoma decreased significantly from 9.2/100,000 women in 1988 to 5.9/100,000 in 2000 (P<0.001). The incidence rate of adenocarcinomas remained stable. After adjustment for age, stage and lymph node involvement, the relative risk of death was 1.6 times higher for patients with adenocarcinomas than for patients with squamous cell carcinoma (95% CI 1.2-2.1). The decreased survival was related to histological type, as the effect remained significant after correction for confounding factors. Over time, the prognosis of women with squamous cell carcinoma improved significantly. No significant change was observed for women diagnosed with adenocarcinoma. These results suggest that the screening programme in The Netherlands as executed in the Greater Amsterdam area is associated with a decreased incidence and increased survival of patients with squamous cell carcinoma, but fails to detect (pre)malignant lesions of adenocarcinoma. Since more than 92% of adenocarcinomas and its precursors contain high-risk HPV, adding HPV testing to cytologic screening might improve the present screening programme in detecting adenocarcinoma and its precursor lesions