Philosophy and Hip-Hop: Ruminations on Postmodern Cultural Form

Book review of Philosophy and Hip-Hop: Ruminations on Postmodern Cultural Form. By Julius Bailey (2014)

Judicial Termination of Treaty Water Rights: The Snake River Case

This article criticized the Idaho district court\u27s resolution of the Nez Perce Tribe\u27s water rights in the Snake River Basin Adjudication (SRBA). The scope of the tribe\u27s claims were considerable, since they included the right to maintain their fishing practices at the time of their 1855 treaty, The article examined the SRBA decision, the purposes of the 1855 treaty, the nature of the tribe\u27s off-reservation water rights, and the unprincipled termination of those rights by the 1999 SRBA court\u27s decision. The article\u27s call for a correction by the Idaho Supreme Court, which the epilogue to the article noted included a conflict-of-interest on the part of the SRBA court, was later obviated by a settlement between the tribe and the state

Prolactin Receptor Signaling Is Essential for Perinatal Brown Adipocyte Function: A Role for Insulin-like Growth Factor-2

BACKGROUND: The lactogenic hormones prolactin (PRL) and placental lactogens (PL) play central roles in reproduction and mammary development. Their actions are mediated via binding to PRL receptor (PRLR), highly expressed in brown adipose tissue (BAT), yet their impact on adipocyte function and metabolism remains unclear. METHODOLOGY/PRINCIPAL FINDINGS: PRLR knockout (KO) newborn mice were phenotypically characterized in terms of thermoregulation and their BAT differentiation assayed for gene expression studies. Derived brown preadipocyte cell lines were established to evaluate the molecular mechanisms involved in PRL signaling on BAT function. Here, we report that newborn mice lacking PRLR have hypotrophic BAT depots that express low levels of adipocyte nuclear receptor PPARgamma2, its coactivator PGC-1alpha, uncoupling protein 1 (UCP1) and the beta3 adrenoceptor, reducing mouse viability during cold challenge. Immortalized PRLR KO preadipocytes fail to undergo differentiation into mature adipocytes, a defect reversed by reintroduction of PRLR. That the effects of the lactogens in BAT are at least partly mediated by Insulin-like Growth Factor-2 (IGF-2) is supported by: i) a striking reduction in BAT IGF-2 expression in PRLR KO mice and in PRLR-deficient preadipocytes; ii) induction of cellular IGF-2 expression by PRL through JAK2/STAT5 pathway activation; and iii) reversal of defective differentiation in PRLR KO cells by exogenous IGF-2. CONCLUSIONS: Our findings demonstrate that the lactogens act in concert with IGF-2 to control brown adipocyte differentiation and growth. Given the prominent role of brown adipose tissue during the perinatal period, our results identified prolactin receptor signaling as a major player and a potential therapeutic target in protecting newborn mammals against hypothermia

Crucified People: The Suffering of the Tortured in Today’s World (Book Review)

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Gender and Violence in Haiti: Women’s Path from Victims to Agents by Benedetta Faedi Duramy

This review of Professor Duramy\u27s book is available from: Human Rights Review, June 2016, Volume 17, Issue 2, pp 279-280

Daniella Zsupan-Jerome, Connected Toward Communion: The Church and Social Communication in the Digital Age

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