Evolution in Surface Morphology of Epitaxial Graphene Layers on SiC Induced by Controlled Structural Strain

The evolution in the surface morphology of epitaxial graphene films and 6H-SiC(0001) substrates is studied by electron channeling contrast imaging. Whereas film thickness is determined by growth temperature only, increasing growth times at constant temperature affect both internal stress and film morphology. Annealing times in excess of 8-10 minutes lead to an increase in the mean square roughness of SiC step edges to which graphene films are pinned, resulting in compressively stressed films at room temperature. Shorter annealing times produce minimal changes in the morphology of the terrace edges and result in nearly stress-free films upon cooling to room temperature.Comment: 3 pages, 2 figures. Applied Physics Letters 93 (2008), 19191

Between a Rock and a Hard Place: Minoritized Communities, Urban School Reform, School Policies, and Mayoral Control

The purpose of this study is to explore a federal turnaround policy under a mayoral-controlled Northeastern school district that began in 2013. The study utilizes discourse and document analysis and interviews, as well as a life history methodology to explore the perspectives of educators, local politicians, and community activists from Black and Latinx communities, as well as other minoritized populations, within the jurisdiction of the school district. The framework for this study draws on a critical analysis of educational policy studies and utilizes Sandra Stein’s (2004) Culture of Education Policy framework to highlight discourses and language used to frame individuals and groups. This study analyzes a forced leadership change and focuses on a particular elementary school as a result of the implementation of a turnaround policy, and offers some implications for educational policy, reform, and leadership practices

Thermodynamics of nano-spheres encapsulated in virus capsids

We investigate the thermodynamics of complexation of functionalized charged nano-spheres with viral proteins. The physics of this problem is governed by electrostatic interaction between the proteins and the nano-sphere cores (screened by salt ions), but also by configurational degrees of freedom of the charged protein N-tails. We approach the problem by constructing an appropriate complexation free energy functional. On the basis of both numerical and analytical studies of this functional we construct the phase diagram for the assembly which contains the information on the assembled structures that appear in the thermodynamical equilibrium, depending on the size and surface charge density of the nano-sphere cores. We show that both the nano-sphere core charge as well as its radius determine the size of the capsid that forms around the core.Comment: Submitte

Investigation of HIV-1 Gag binding with RNAs and Lipids using Atomic Force Microscopy

Atomic Force Microscopy was utilized to study the morphology of Gag, {\Psi}RNA, and their binding complexes with lipids in a solution environment with 0.1{\AA} vertical and 1nm lateral resolution. TARpolyA RNA was used as a RNA control. The lipid used was phospha-tidylinositol-(4,5)-bisphosphate (PI(4,5)P2). The morphology of specific complexes Gag-{\Psi}RNA, Gag-TARpolyA RNA, Gag-PI(4,5)P2 and PI(4,5)P2-{\Psi}RNA-Gag were studied. They were imaged on either positively or negatively charged mica substrates depending on the net charges carried. Gag and its complexes consist of monomers, dimers and tetramers, which was confirmed by gel electrophoresis. The addition of specific {\Psi}RNA to Gag is found to increase Gag multimerization. Non-specific TARpolyA RNA was found not to lead to an increase in Gag multimerization. The addition PI(4,5)P2 to Gag increases Gag multimerization, but to a lesser extent than {\Psi}RNA. When both {\Psi}RNA and PI(4,5)P2 are present Gag undergoes comformational changes and an even higher degree of multimerization

Wheel-running activity modulates circadian organization and the daily rhythm of eating behavior

Consumption of high-fat diet acutely alters the daily rhythm of eating behavior and circadian organization (the phase relationship between oscillators in central and peripheral tissues) in mice. Voluntary wheel-running activity counteracts the obesogenic effects of high-fat diet and also modulates circadian rhythms in mice. In this study, we sought to determine whether voluntary wheel-running activity could prevent the proximate effects of high-fat diet consumption on circadian organization and behavioral rhythms in mice. Mice were housed with locked or freely rotating running wheels and fed chow or high-fat diet for 1 week and rhythms of locomotor activity, eating behavior, and molecular timekeeping (PERIOD2::LUCIFERASE luminescence rhythms) in ex vivo tissues were measured. Wheel-running activity delayed the phase of the liver rhythm by 4 h in both chow- and high-fat diet-fed mice. The delayed liver phase was specific to wheel-running activity since an enriched environment without the running wheel did not alter the phase of the liver rhythm. In addition, wheel-running activity modulated the effect of high-fat diet consumption on the daily rhythm of eating behavior. While high-fat diet consumption caused eating events to be more evenly dispersed across the 24 h-day in both locked-wheel and wheel-running mice, the effect of high-fat diet was much less pronounced in wheel-running mice. Together these data demonstrate that wheel-running activity is a salient factor that modulates liver phase and eating behavior rhythms in both chow- and high-fat-diet fed mice. Wheel-running activity in mice is both a source of exercise and a self-motivating, rewarding behavior. Understanding the putative reward-related mechanisms whereby wheel-running activity alters circadian rhythms could have implications for human obesity since palatable food and exercise may modulate similar reward circuits

Stiction, Adhesion Energy and the Casimir Effect in Micromechanical Systems

We measure the adhesion energy of gold using a micromachined doubly-clamped beam. The stress and stiffness of the beam are characterized by measuring the spectrum of mechanical vibrations and the deflection due to an external force. To determine the adhesion energy we induce stiction between the beam and a nearby surface by capillary forces. Subsequent analysis yields a value $\gamma =0.06$ J/m$^{2}$ that is a factor of approximately six smaller than predicted by idealized theory. This discrepancy may be resolved with revised models that include surface roughness and the effect of adsorbed monolayers intervening between the contacting surfaces in these mesoscopic structures.Comment: RevTex, 4 pages, 4 eps figure

The outcome of antibiotics as surgical prophylaxis in gynecological procedures - a retrospective study in a south Indian hospital

Background: The aim of the study was to evaluate the outcome of antibiotics as surgical prophylactic measure for gynecological procedures in a south Indian Hospital.Methods: A retrospective study was conducted in 150 women who underwent caesarean, hysterectomies, Dilation and Curettage, myomectomy, operative vaginal delivery and were prescribed antibiotics. The data regarding demographic details, presenting complaints, parity, obstetrics history, diagnosis and need for surgery was evaluated.Results: A total of 206 women admitted with surgical procedures performed were taken into consideration of which 150 were prescribed antibiotics alone but 26 patients did not respond to treatment and were given other antibiotics, 30 patients were shifted to other specialist departments or other hospital for better treatment due to economic status, hence 150 patients formed the study population. The mean age was years. Patients above years were mostly seen.Conclusions: In our study, cefuroxime appeared to be effective in prophylaxis against infections. Metronidazole appeared to be ineffective compared to Cefuroxime. Combination of Cefuroxime and metronidazole was less effective compared to Amoxicillin and potassium clavunate. Cefazolin was commonly prescribed for gynecological procedures

Participation in physical activity in patients 1–4 years post total joint replacement in the Dominican Republic

Background: To address both the growing burden of joint disease and the gaps in medical access in developing nations, medical relief organizations have begun to launch programs to perform total joint replacement (TJR) on resident populations in developing countries. One outcome of TJR of particular interest is physical activity (PA) since it is strongly linked to general health. This study evaluates the amount of postoperative participation in PA in low-income patients who received total joint replacement in the Dominican Republic and identifies preoperative predictors of postoperative PA level. Methods: We used the Yale Physical Activity Survey (YPAS) to assess participation in postoperative PA 1–4 years following total knee or hip replacement. We compared the amount of aerobic PA reported by postoperative TJR patients with the levels of PA recommended by the CDC and WHO. We also analyzed preoperative determinants of postoperative participation in aerobic PA in bivariate and multivariate analyses. Results: 64 patients out of 170 eligible subjects (52/128 TKR and 14/42 THR) who received TJR between 2009–2012 returned for an annual follow-up visit in 2013, with a mean treatment-to-follow-up time of 2.1 years. 43.3% of respondents met CDC/WHO criteria for sufficient participation in aerobic PA. Multivariate analyses including data from 56 individuals identified that patients who were both younger than 65 and at least two years postoperative had an adjusted mean activity dimensions summary index (ADSI) 22.9 points higher than patients who were 65 or older and one year postoperative. Patients who lived with friends or family had adjusted mean ADSI 17.2 points higher than patients living alone. Patients who had the most optimistic preoperative expectations of outcome had adjusted mean ADSI scores that were 19.8 points higher than those who were less optimistic. Conclusion: The TJR patients in the Dominican cohort participate in less PA than recommended by the CDC/WHO. Additionally, several associations were identified that potentially affect PA in this population; specifically, participants who are older than 65, recently postoperative, less optimistic about postoperative outcomes and who live alone participate in less PA