Evidence of endothelial dysfunction in the development of Alzheimer's disease : Is Alzheimer's a vascular disorder?

Acknowledgements Dr Soiza is funded by an NRS Career Research Fellowship. The authors are grateful to Alzheimer’s Research UK for providing funding.Peer reviewedPublisher PD

The pale evidence for treatment of iron-deficiency anaemia in older people

Funding The authors have received funding to carry out a pilot RCT on management of IDA in older people from the Chief Scientist Office, Scotland.Peer reviewedPostprin

Prevalence, incidence and etiology of hyponatremia in elderly patients with fragility fractures

Peer reviewedPublisher PD

Prognosis of hyponatremia in elderly patients with fragility fractures

Funding This work is supported by an NHS Research Scotland (NRS) Career Research Fellowship to Dr Soiza.Peer reviewedPublisher PD

Efficacy and safety of COVID-19 vaccines in older people

Declaration of Conflicts of Interest R.L.S. is a principal investigator in the Novavax COVID-19 vaccine trial. C.S. is a sub-investigator in the Novavax COVID-19 vaccine trial. E.C.T. has no conflicts of interest to declare. Views expressed are the authors’ own.Peer reviewedPostprin

Editorial : Deprescribing and Minimizing Use of Anticholinergic Medications

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Oral Bicarbonate Therapy in Non-Haemodialysis Dependent Chronic Kidney Disease Patients : A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Supplementary Materials: The following are available online at www.mdpi.com/2077-0383/8/2/208/s1, Supplementary Figure S1. Forest plot comparing the effects of oral bicarbonate therapy and control on serum creatinine levels. Supplementary Figure S2. Forest plot comparing the effects of oral bicarbonate therapy and control on eGFR at one year. Supplementary Figure S3. Forest plot comparing the effects of oral bicarbonate therapy and control on serum bicarbonate levels at one year. . Funding: This work was supported by a National Institute of Health Research Health Technology Assessment (NIHR HTA) project grant (Ref: 10/71/10).Peer reviewedPublisher PD

The Scottish Intercollegiate Guidelines Network (SIGN) 157: Guidelines on Risk Reduction and Management of Delirium : Communication

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Evidence of and recommendations for non-pharmacological interventions for common geriatric conditions: the SENATOR-ONTOP systematic review protocol.

Introduction: Non-pharmacological therapies for common chronic medical conditions in older patients are underused in clinical practice. We propose a protocol for the assessment of the evidence of non-pharmacological interventions to prevent or treat relevant outcomes in several prevalent geriatric conditions in order to provide recommendations. Methods and analysis: The conditions of interest for which the evidence about efficacy of non-pharmacological interventions will be searched include delirium, falls, pressure sores, urinary incontinence, dementia, heart failure, orthostatic hypotension, sarcopaenia and stroke. For each condition, the following steps will be undertaken: (A) prioritising clinical questions; (B) retrieving the evidence (MEDLINE, the Cochrane Library, CINAHL and PsychINFO will be searched to identify systematic reviews); (C) assessing the methodological quality of the evidence (risk of bias according to the Cochrane method will be applied to the primary studies retrieved from the systematic reviews); (D) developing recommendations based on the evidence (Grading of Recommendations Assessment, Development and Evaluation (GRADE) items—risk of bias, imprecision, inconsistency, indirectness and publication bias—will be used to rate the overall evidence and develop recommendations). Dissemination: For each target condition, at least one systematic overview concerning the evidence of non-pharmacological interventions will be produced and published in peer-reviewed journals

Evidence of and recommendations for non-pharmacological interventions for common geriatric conditions : the SENATOR-ONTOP systematic review protocol

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.Peer reviewedPublisher PD