4,412 research outputs found
A global function for transcription factors in assisting RNA polymerase II termination.
The role of transcription factors (TFs) on nucleosome positioning, RNA polymerase recruitment, and transcription initiation has been extensively characterized. Here, we propose that a subset of TFs such as Reb1, Abf1, Rap1, and TFIIIB also serve a major function in partitioning transcription units by assisting the Nrd1p-Nab3p-Sen1p Pol II termination pathway
Design and synthesis of novel inhibitors of the p53-Mdm2 interaction and the development of novel inhibitors of cyclin dependent kinases
SMART WALL OUTLET DESIGN AND IMPLEMENTATION FOR THE DC HOUSE PROJECT
Most everyday AC appliances are designed to operate off of 120V coming from the wall outlet in our homes. This voltage is a standard set from our established infrastructure. Unlike AC devices, DC devices do not have any set standard of voltage they all will run off of. This presents a problem for the DC house as the various loads that will be used will have different required input voltages. One set voltage for a wall outlet will not suffice for the DC House. This Smart Wall Outlet is designed with a DC-DC converter that will have its output voltage controlled by an on-board microprocessor. The Smart Wall Outlet detects current going into a device, and will adjust the voltage applied to the device to ensure it operates most efficiently. Proof of concept research has already been performed in the past, and this thesis will look towards implementing this concept on a single circuit board
SLIQ: Simple Linear Inequalities for Efficient Contig Scaffolding
Scaffolding is an important subproblem in "de novo" genome assembly in which
mate pair data are used to construct a linear sequence of contigs separated by
gaps. Here we present SLIQ, a set of simple linear inequalities derived from
the geometry of contigs on the line that can be used to predict the relative
positions and orientations of contigs from individual mate pair reads and thus
produce a contig digraph. The SLIQ inequalities can also filter out unreliable
mate pairs and can be used as a preprocessing step for any scaffolding
algorithm. We tested the SLIQ inequalities on five real data sets ranging in
complexity from simple bacterial genomes to complex mammalian genomes and
compared the results to the majority voting procedure used by many other
scaffolding algorithms. SLIQ predicted the relative positions and orientations
of the contigs with high accuracy in all cases and gave more accurate position
predictions than majority voting for complex genomes, in particular the human
genome. Finally, we present a simple scaffolding algorithm that produces linear
scaffolds given a contig digraph. We show that our algorithm is very efficient
compared to other scaffolding algorithms while maintaining high accuracy in
predicting both contig positions and orientations for real data sets.Comment: 16 pages, 6 figures, 7 table
Integrated Urban Waste Management in the Philippines:Interface of Waste-to-Energy Development and Social Participation(フィリピンの総合的な都市廃棄物管理-廃棄物によるエネルギー開発と社会参加の調和-)
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