44 research outputs found
Association of the PHACTR1/EDN1 genetic locus with spontaneous coronary artery dissection
Background:
Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of acute coronary syndromes (ACS) afflicting predominantly younger to middle-aged women. Observational studies have reported a high prevalence of extracoronary vascular anomalies, especially fibromuscular dysplasia (FMD) and a low prevalence of coincidental cases of atherosclerosis. PHACTR1/EDN1 is a genetic risk locus for several vascular diseases, including FMD and coronary artery disease, with the putative causal noncoding variant at the rs9349379 locus acting as a potential enhancer for the endothelin-1 (EDN1) gene.
Objectives:
This study sought to test the association between the rs9349379 genotype and SCAD.
Methods:
Results from case control studies from France, United Kingdom, United States, and Australia were analyzed to test the association with SCAD risk, including age at first event, pregnancy-associated SCAD (P-SCAD), and recurrent SCAD.
Results:
The previously reported risk allele for FMD (rs9349379-A) was associated with a higher risk of SCAD in all studies. In a meta-analysis of 1,055 SCAD patients and 7,190 controls, the odds ratio (OR) was 1.67 (95% confidence interval [CI]: 1.50 to 1.86) per copy of rs9349379-A. In a subset of 491 SCAD patients, the OR estimate was found to be higher for the association with SCAD in patients without FMD (OR: 1.89; 95% CI: 1.53 to 2.33) than in SCAD cases with FMD (OR: 1.60; 95% CI: 1.28 to 1.99). There was no effect of genotype on age at first event, P-SCAD, or recurrence.
Conclusions:
The first genetic risk factor for SCAD was identified in the largest study conducted to date for this condition. This genetic link may contribute to the clinical overlap between SCAD and FMD
La curieuse ponte tubuleuse des perches
Roule Louis. La curieuse ponte tubuleuse des perches. In: La Terre et La Vie, Revue d'Histoire naturelle, tome 1, n°2, 1931. pp. 77-81
Consid\ue9ration sur les deux esp\ue8ces abyssales du genre Solea dans l’Atlantique pal\ue9arctique et sur le sous-genre nouveau Bathysolea
Volume: 22Start Page: 8End Page: 1
Poissons étranges
Roule Louis. Poissons étranges. In: La Terre et La Vie, Revue d'Histoire naturelle, tome 2, n°1, 1932. pp. 25-28
Conférence Lamarck. Lamarck, sa vie et son œuvre
Roule Louis. Conférence Lamarck. Lamarck, sa vie et son œuvre. In: Bulletins et Mémoires de la Société d'anthropologie de Paris, VII° Série. Tome 10, 1929. pp. 46-61