Wide bandwidth LFM transmission through a wavelength-controlled photonic true time delay device

We demonstrate for the first time high quality wide bandwidth (600 MHz) LFM transmission through a wavelength-controlled photonic true time delay device with bandwidth-limited resolution and peak sidelobe level below -37 dB at 5 GHz

Performance issues with photonic beamformers

A photonic beamformer is presented, having smooth behavior. Third-order nonlinearities, resulting from its optoelectronic components, are investigated, with emphasis on their impact on the contrast of imaging radars. This contrast is shown to be severely limited by the induced RF nonlinearities. Limitations on the allowable modulation index are studied for linearly-chirped pulses returned from clutter

Genetic modifiers of stroke in patients with sickle cell disease: a scoping review

This work was partially supported by H&TRC, FCT/MCTES grant number (UIDB/05608/2020 and UIDP/05608/2020) and the Dana-Farber/Boston Children’s Cancer and Blood Disorders Center Talent Development Award.Sickle cell disease (SCD) clinically manifests itself with a myriad of complications. Stroke, both ischemic and hemorrhagic, as well as silent white matter changes, occurs at a relatively high prevalence. Understanding why and in whom stroke is most likely to occur is critical to the effective prevention and treatment of individuals with SCD. Genetic studies, including genome- and exome-wide association studies (GWAS and EWAS), have found several key modifiers associated with increased stroke/stroke risk in SCD via mechanisms including Hemoglobin F (HbF) modulation, inflammation, cellular adhesion, endothelial disruption, and hemolysis. We present a review of the modifiers that have most clearly demonstrated an association to date. More studies are needed to validate other potential polymorphisms and identify new ones. Incorporating gene-focused screenings in clinical care could provide avenues for more targeted, more effective, and less toxic prevention of stroke in this population. The data from this review will be used to inform the initial GWAS performed by the International Hemoglobinopathy Research Network (INHERENT) consortium.info:eu-repo/semantics/publishedVersio

Difficult management of an extremely rare case of giant pigmented epithelioid melanocytoma

Pigmented epithelioid melanocytoma (PEM), a heavily pigmented and highly uncommon melanocytic lesion, is extremely rare. It comes under several forms and names. We report the case of a three-year-old boy born with an isolated right lumbopelvic and femoral giant PEM. The boy was unable to walk due to the size and the shape of the lesion. He underwent two stages of intra lesional resections, one in Benin and the second in Switzerland. The first surgery was followed by hypothetic hypovolemic and anaphylactic shocks, and the second surgery by a continuous lymphatic leakage from the wounds for months. The strategic management approach, the surgery and follow-up of this case of giant PEM presented a real challenge. (C) 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND licens

Performance issues with photonic beamformers

A photonic beamformer is presented, having smooth behavior. Third-order nonlinearities, resulting from its optoelectronic components, are investigated, with emphasis on their impact on the contrast of imaging radars. This contrast is shown to be severely limited by the induced RF nonlinearities. Limitations on the allowable modulation index are studied for linearly-chirped pulses returned from clutter

Extending structures I: the level of groups

Let $H$ be a group and $E$ a set such that $H \subseteq E$. We shall describe and classify up to an isomorphism of groups that stabilizes $H$ the set of all group structures that can be defined on $E$ such that $H$ is a subgroup of $E$. A general product, which we call the unified product, is constructed such that both the crossed product and the bicrossed product of two groups are special cases of it. It is associated to $H$ and to a system $\bigl((S, 1_S,\ast), \triangleleft, \, \triangleright, \, f \bigl)$ called a group extending structure and we denote it by $H \ltimes S$. There exists a group structure on $E$ containing $H$ as a subgroup if and only if there exists an isomorphism of groups $(E, \cdot) \cong H \ltimes S$, for some group extending structure $\bigl((S, 1_S,\ast), \triangleleft, \, \triangleright, \, f \bigl)$. All such group structures on $E$ are classified up to an isomorphism of groups that stabilizes $H$ by a cohomological type set ${\mathcal K}^{2}_{\ltimes} (H, (S, 1_S))$. A Schreier type theorem is proved and an explicit example is given: it classifies up to an isomorphism that stabilizes $H$ all groups that contain $H$ as a subgroup of index 2.Comment: 17 pages; to appear in Algebras and Representation Theor

Bicrossed products for finite groups

We investigate one question regarding bicrossed products of finite groups which we believe has the potential of being approachable for other classes of algebraic objects (algebras, Hopf algebras). The problem is to classify the groups that can be written as bicrossed products between groups of fixed isomorphism types. The groups obtained as bicrossed products of two finite cyclic groups, one being of prime order, are described.Comment: Final version: to appear in Algebras and Representation Theor

Pulmonary valve stenosis due to undifferentiated pleomorphic sarcoma

Pulmonary artery sarcomas are uncommon intracardiac tumours with poor prognosis. We report the case of a 69-year-old woman in good health presenting with rapidly progressive dyspnoea and an unfamiliar systolic murmur. Echocardiography revealed pulmonary valve stenosis due to an obstructing mobile mass. Imaging studies confirmed the presence of a contrast-enhancing lesion adherent to the valve, extending into the pulmonary trunk and right ventricular outflow tract, and suggestive of malignancy. Endovascular biopsy was attempted with no success. Surgical resection with autologous graft valve replacement and pulmonary artery reconstruction was performed. Postoperative histological examination confirmed the diagnosis of an undifferentiated pleomorphic sarcoma. Pulmonary artery sarcoma should be considered as a rare differential diagnosis in patients presenting with dyspnoea and a crescendo-decrescendo systolic murmur increasing with inspiration. Echocardiography is a useful first diagnostic approach but multi-imaging assessment is almost always necessary for definite diagnosis. Our case provides insights into the challenges met by cardiologists, radiologists and cardiac surgeons in the management of such cases