Mapping five new candidate genes in the pig

Five new candidate genes for growth and carcass traits have recently been mapped in the pig by using either linkage analysis or analysis of a hybrid cell line panel. The genes mapped include the very long chain acyl-CoA dehydrogenase gene (ACADVL) mapped to pig chromosome 12, the adenylate cyclase activating peptide, pituitary 1 gene (ADCYAP1) on chromosome 6, the calpain large polypeptide L3 gene (CAPN3), the myocyte-specific enhancer factor 2A gene (MEF2A) on chromosome 1, and the thyroid stimulating hormone receptor gene (TSHR) on chromosome 7. All five genes have the potential to influence carcass traits in the pig. Future studies will be conducted to investigate if any of the genes actually do influence these traits

Addition of Thirteen Genes to the Porcine Comparative Gene Map Reveals New Regions of Conserved Synteny

Thirteen genes were mapped to the porcine genome by using either linkage mapping of the PiGMaP families (eight genes) or typing of a porcine somatic cell hybrid panel (12 genes). The genes were chosen from interesting locations in the human genome. The physical gene assignments to pig chromosomes (SSC) with corresponding human chromosome (HSA) locations include the following: FGF7 (HSA15), MADH4 (HSA18), and MC4R (HSA18) to SSC1, RXRB (HSA6), and SSTR1 (HSA14) to SSC7, UCP1 (HSA4) to SSC8, PGR (HSA11) to SSC9, TTN (HSA2) and ANT1 (HSA4) to SSC15, GRIA1 (HSA5) to SSC16, AR (HSA-X), and GRIA3 (HSA-X) to SSC-X. Additionally, CD59 (HSA11) was linkage mapped to SSC2. The majority of the assignments confirm results from bidirectional chromosome painting (4). A rearrangement in gene order was detected within the region of correspondence between SSC1 and HSA15. Two assignments were made that were not expected from the painting results (MC4R and GRIA1) and one assignment of a gene from a region where the painting study was not informative (ANT1)

EXIST: The Ultimate Spatial/Temporal Hard X-ray Survey

The Energetic X-ray Imaging Survey Telescope (EXIST) is a proposed mission to conduct an all-sky imaging hard x-ray (HX) survey (~5–600 keV) with ~0.05mCrab sensitivity (5σ; 6mo.; ~5–100keV) comparable to the ROSAT soft x-ray survey, and to provide the maximum sensitivity and resolution (spatial and temporal) HX imager as the Next Generation GRB mission. Its primary science goals are to i) identify and measure obscured AGN and constrain the accretion luminosity of the universe as well as the cosmic IR background from Blazar spectra coincident with GeV-TeV observations, ii) measure spectra, variability and locations for the faintest GRBs to study the most energetic events in the universe and the earliest epoch of star formation, and iii) study black holes on all scales, from x-ray transients to luminous AGN. EXIST would incorporate a very large area (~8m^2) imaging Cd-Zn-Te detector and coded aperture telescope array with nearly half-sky instantaneous view which images the full sky each orbit. With fixed zenith pointing, it could be mounted on the ISS or a free flyer and would complement both GLAST and Constellation-X science if launched before 2010, as recommended by the Astronomy and Astrophysics Decadal Survey

First Constraints on Iron Abundance versus Reflection Fraction from the Seyfert~1 Galaxy MCG--6-30-15

We report on a joint ASCA and RXTE observation spanning an $\sim$ 400~ks time interval of the bright Seyfert~1 galaxy MCG--6-30-15. The data clearly confirm the presence of a broad skewed iron line ($W_{K\alpha} \sim$ 266 eV) and Compton reflection continuum at higher energies reported in our previous paper. We also investigate whether the gravitational and Doppler effects that affect the iron line may also be manifest in the reflected continuum. The uniqueness of this data set is underlined by the extremely good statistics that we obtain from the approximately four million photons that make up the 2-20 keV RXTE PCA spectrum alone. This, coupled with the high energy coverage of HEXTE and the spectral resolution of ASCA in the iron line regime has allowed us to constrain the relationship between abundance and reflection fraction for the first time at the 99 per cent confidence level. The reflection fraction is entirely consistent with a flat disk, i.e. the cold material subtends $\rm 2 \pi$ sr at the source, to an accuracy of 20 per cent. Monte Carlo simulations show that the observed strong iron line intensity is explained by an overabundance of iron by a factor of $\sim$ 2 and an underabundance of the lower-Z elements by a similar factor. By considering non-standard abundances, a clear and consistent picture can be made in which both the iron line and reflection continuum come from the same material such as e.g. an accretion disk.Comment: 8 pages, 8 figures, accepted for publication MNRAS 7/9

Neutron star composition in strong magnetic fields

We study the problem of neutron star composition in the presence of a strong magnetic field. The effects of the anomalous magnetic moments of both nucleons and electrons are investigated in relativistic mean field calculations for a $\beta$-equilibrium system. Since neutrons are fully spin polarized in a large field, generally speaking, the proton fraction can never exceed the field free case. An extremely strong magnetic field may lead to a pure neutron matter instead of a proton-rich matter.Comment: 12 pages, 3 postscript files include

HST Observations of SGR 0526-66: New Constraints on Accretion and Magnetar Models

Soft Gamma-ray Repeaters (SGRs) are among the most enigmatic sources known today. Exhibiting huge X- and Gamma-ray bursts and flares, as well as soft quiescent X-ray emission, their energy source remains a mystery. Just as mysterious are the Anomalous X-ray pulsars (AXPs), which share many of the same characteristics. Thanks to recent Chandra observations, SGR 0526-66, the first SGR, now appears to be a transition object bridging the two classes, and therefore observations of it have implications for both SGRs and AXPs. The two most popular current models for their persistent emission are accretion of a fossil disk or decay of an enormous (~10^15 G) magnetic field in a magnetar. We show how deep optical observations of SGR 0526-66, the only SGR with small enough optical extinction for meaningful observations, show no evidence of an optical counterpart. These observation place strong new constraints on both accretion disk and magnetar models, and suggest that the spectral energy distribution may peak in the hard-UV. Almost all accretion disks are excluded by the optical data, and a magnetar would require a ~10^15-10^16 G field.Comment: 23 pages, 5 figures. Accepted by Ap

The Galactic 26Al Problem and The Close Binary SNIb/c Solution?

The origin of the long-lived radioactive 26Al, which has been observed in the Galactic interstellar medium from its 1.809 MeV decay gamma-ray line emission, has been a persistent problem for over twenty years. Wolf-Rayet (WR) winds were thought to be the most promising source, but their calculated 26Al yields are not consistent with recent analyses of the 1.809 MeV emission from the nearest WR star and nearby OB associations. The expected 26Al yield from the WR star exceeds by as much as a factor of 3, that set by the 2-sigma upper limit on the 1.809 MeV emission, while the WR yields in the OB associations are only about 1/3 of that required by the 1.809 MeV emission. We suggest that a solution to these problems may lie in 26Al from a previously ignored source: explosive nucleosynthesis in the core collapse SNIb/c supernovae of WR stars that have lost most of their mass to close binary companions. Recent nucleosynthetic calculations of SNIb/c suggest that their 26Al yields depend very strongly on the final, pre-supernova mass of the WR star, and that those with final masses around 6 to 8 solar masses are expected to produce as much as 0.01 solar masses of 26Al per supernova. Such binary SNIb/c make up only a small fraction of the current SNIb/c and only about 1% of all Galactic core collapse supernovae. They appear to be such prolific sources that the bulk of the present 26Al in the Galaxy may come from just a few hundred close binary SNIb/c and the intense 1.809 MeV emission from nearby OB associations may come from just one or two such supernova.Comment: Accepted for publication in Astrophysical Journal Letters, 611,10 August 200

Editorial: Why livestock genomics for developing countries offers opportunities for success.

Universidad Nacional Agraria La Molina. Escuela de Posgrado. Maestría en Producción AnimalThe Research Topic yielded 23 articles that are either review (five papers) or original research articles (18 papers) covering major livestock species kept in developing countries including cattle (seven papers), sheep (five papers), goats (three papers), and chickens (three papers). The manuscripts cover a broad range of genomic applications such as genomic selection/assisted breeding, genome-wide association analysis, diversity studies with a particular emphasis on adaptive genetic variation and signatures of selection analysis, and some elements of functional genomics using RNA sequencing and differential gene expression profiling. Whilst a broad range of genomic applications are covered, there is a bias toward genomic diversity studies, indicating the limited utility of other genomic applications due to inherent limitations to data collection and funding that characterize most developing countries, and are highlighted in some of the review article

Positron Annihilation in the Galaxy

The 511 keV line from positron annihilation in the Galaxy was the first γ-ray line detected to originate from outside our solar system. Going into the fifth decade since the discovery, the source of positrons is still unconfirmed and remains one of the enduring mysteries in γ-ray astronomy. With a large flux of ∼10−3 γ/cm2/s, after 15 years in operation INTEGRAL/SPI has detected the 511 keV line at >50σ and has performed high-resolution spectral studies which conclude that Galactic positrons predominantly annihilate at low energies in warm phases of the interstellar medium. The results from imaging are less certain, but show a spatial distribution with a strong concentration in the center of the Galaxy. The observed emission from the Galactic disk has low surface brightness and the scale height is poorly constrained, therefore, the shear number of annihilating positrons in our Galaxy is still not well know. Positrons produced in β+-decay of nucleosynthesis products, such as 26Al, can account for some of the annihilation emission in the disk, but the observed spatial distribution, in particular the excess in the Galactic bulge, remains difficult to explain. Additionally, one of the largest uncertainties in these studies is the unknown distance that positrons propagate before annihilation. In this paper, we will summarize the current knowledge base of Galactic positrons, and discuss how next-generation instruments could finally provide the answers.Non peer reviewedFinal Accepted Versio