604 research outputs found

    Potential Identification of sublimation-driven downslope mass movement on Mercury

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    We have identified a further example of mass movement, in addition to the previously identified example in the pyroclastic vent NE of Rachmaninoff. Both examples show evidence of hollow sublimation being a cause of the mass movements

    1:3M Geological Mapping of the Derain (H-10) Quadrangle of Mercury

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    We are making a high resolution geological map of the Derain quadrangle of Mercury. This is part of a coordinated project to create a global set of geological maps for BepiColombo

    Ships\u27 Lights, and the Rule of the Road

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    Ships\u27 Lights, and the Rule of the Road

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    Inhaled corticosteroids reduce senescence in endothelial progenitor cells from COPD patients

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    Cellular senescence contributes to the pathophysiology of chronic obstructive pulmonary disease (COPD) and cardiovascular disease. Using endothelial-colony-forming-cells (ECFC), we have demonstrated accelerated senescence in smokers and COPD patients compared to non-smokers. Subgroup analysis suggests that ECFC from COPD patients on inhaledcorticosteroids (ICS) (n=14; 8 on ICS) exhibited significantly reduced senescence (Senescence-associated-beta galactosidase activity, p21CIP1), markers of DNA damage response (DDR) and IFN-γ-inducible-protein-10 compared to COPD patients not on ICS. In vitro studies using human-umbilical-vein-endothelial-cells showed a protective effect of ICS on the DDR, senescence and apoptosis caused by oxidative-stress, suggesting a protective molecular mechanism of action of corticosteroids on endothelium
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