Changes of Immunological Profiles in Patients with Chronic Myeloid Leukemia in the Course of Treatment

In the previous paper of ours we compared, prior to start any treatment, a number of immunological parameters in 24 chronic myeloid leukemia patients with the same number of healthy subjects matched by age and sex. We found significant differences in the levels of immunoglobulins, the C4 component of complement, the C-reactive protein, interleukin 6, the composition of lymphocyte population and the production of some cytokines by stimulated CD3+ cells. Eleven of these patients were followed longitudinally. After treatment with hydroxyurea, interferon alpha, imatinib mesylate and dasatinib, or various combinations thereof, hematological remission was achieved in all patients and complete cytogenetic remission in nine of them. There was a nearly general tendency towards normalization of the abnormalities observed in the patients at their enrollment

Magnetron-sputtered copper nanoparticles: lost in gas aggregation and found by in situ X-ray scattering

Magnetron discharge in a cold buffer gas represents a liquid-free approach to the synthesis of metal nanoparticles (NPs) with tailored structure, chemical composition and size. Despite a large number of metal NPs that were successfully produced by this method, the knowledge of the mechanisms of their nucleation and growth in the discharge is still limited, mainly because of the lack of in situ experimental data. In this work, we present the results of in situ Small Angle X-ray Scattering measurements performed in the vicinity of a Cu magnetron target with Ar used as a buffer gas. Condensation of atomic metal vapours is found to occur mainly at several mm distance from the target plane. The NPs are found to be captured preferentially within a region circumscribed by the magnetron plasma ring. In this capture zone, the NPs grow to the size of 90 nm whereas smaller ones sized 10–20 nm may escape and constitute a NP beam. Time-resolved measurements of the discharge indicate that the electrostatic force acting on the charged NPs may be largely responsible for their capturing nearby the magnetron

Wooded grasslands as part of the European agricultural heritage

Wooded grasslands have always played an important role in rural life with changing issues: They are of high importance for questions of biodiversity, soil, and water resources and in preserving agricultural heritage, but their maintenance is labor intensive. Abandoned wooded grasslands undergo succession, and food production alone does not support their survival. They require special attention and at the beginning a well-established subsidy system can help to contribute to their survival. Their sustainable use in the present-day landscapes can only be conceivable in complexity where food production, reintroduction of their cultural values, biodiversity and landscape protection, and ecotourism are playing an important role. This chapter gives an overview on the recent situation of wooded grasslands and their historical development, based on the work done by the Institute for Research on European Agricultural Landscapes (www.​eucalandnetwork.​eu). National pictures, definitions, history (including local names), threats, potentials, cultural values, spatial distributions, subtypes, and available databases have been collected, described, and analyzed. The main results of this survey are as follows: (1) Wooded grasslands are known to the public but mainly to local communities where they occur; (2) Many subtypes of wooded grasslands exist in various European countries; (3) Wooded grasslands underwent tremendous changes during the past centuries and lost their importance for various reasons; (4) There are many local and regional projects focusing on wooded grasslands, often as “lighthouse” projects to valorise cultural achievements

Wooded grasslands as part of the European agricultural heritage

Wooded grasslands have always played an important role in rural life with changing issues: They are of high importance for questions of biodiversity, soil, and water resources and in preserving agricultural heritage, but their maintenance is labor intensive. Abandoned wooded grasslands undergo succession, and food production alone does not support their survival. They require special attention and at the beginning a well-established subsidy system can help to contribute to their survival. Their sustainable use in the present-day landscapes can only be conceivable in complexity where food production, reintroduction of their cultural values, biodiversity and landscape protection, and ecotourism are playing an important role. This chapter gives an overview on the recent situation of wooded grasslands and their historical development, based on the work done by the Institute for Research on European Agricultural Landscapes (www.​eucalandnetwork.​eu). National pictures, definitions, history (including local names), threats, potentials, cultural values, spatial distributions, subtypes, and available databases have been collected, described, and analyzed. The main results of this survey are as follows: (1) Wooded grasslands are known to the public but mainly to local communities where they occur; (2) Many subtypes of wooded grasslands exist in various European countries; (3) Wooded grasslands underwent tremendous changes during the past centuries and lost their importance for various reasons; (4) There are many local and regional projects focusing on wooded grasslands, often as “lighthouse” projects to valorise cultural achievements