54 research outputs found
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
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North Texas Crime and Criminal Justice Series; no. 10
Convict Cowboys is the first book on the nation’s first prison rodeo, which ran from 1931 to 1986. At its apogee the Texas Prison Rodeo drew 30,000 spectators on October Sundays. Mitchel P. Roth portrays the Texas Prison Rodeo against a backdrop of Texas history, covering the history of rodeo, the prison system, and convict leasing, as well as important figures in Texas penology including Marshall Lee Simmons, O.B. Ellis, and George J. Beto, and the changing prison demimonde.
Over the years the rodeo arena not only boasted death-defying entertainment that would make professional cowboys think twice, but featured a virtual who’s who of American popular culture. Readers will be treated to stories about numerous American and Texas folk heroes, including Western film stars ranging from Tom Mix to John Wayne, and music legends such as Johnny Cash and Willie Nelson. Through extensive archival research Roth introduces readers to the convict cowboys in both the rodeo arena and behind prison walls, giving voice to a legion of previously forgotten inmate cowboys who risked life and limb for a few dollars and the applause of free-world crowds. The contents include: Texas prisons: a pattern of neglect -- A cowboy's a man with guts and a hoss -- The Simmons years (1930-1935) -- The only show of its kind in the United States (1936-1939) -- The war years (1940-1946) -- A sad state of affairs (1947-1949) -- The West as it ought to have been (1950-1953) -- Outlaw vs. outlaw (1954-1959) -- The fund just appeared footloose and fancy free (1954-1960) -- The Texas Prison
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Number 8 in the North Texas Crime and Criminal Justice Series
Houston Blue offers the first comprehensive history of one of the nation’s largest police forces, the Houston Police Department. Through extensive archival research and more than one hundred interviews with prominent Houston police figures, politicians, news reporters, attorneys, and others, authors Mitchel P. Roth and Tom Kennedy chronicle the development of policing in the Bayou City from its days as a grimy trading post in the 1830s to its current status as the nation’s fourth largest city. Prominent historical figures who have brushed shoulders with Houston’s Finest over the past 175 years include Houdini, Teddy Roosevelt and his Rough Riders, O. Henry, former Texas Ranger Frank Hamer, hatchet wielding temperance leader Carrie Nation, the Hilton Siamese Twins, blues musician Leadbelly, oilman Silver Dollar Jim West, and many others. The Houston Police Department was one of the first cities in the South to adopt fingerprinting as an identification system and use the polygraph test, and under the leadership of its first African American police chief, Lee Brown, put the theory of neighborhood oriented policing into practice in the 1980s. The force has been embroiled in controversy and high profile criminal cases as well. Among the cases chronicled in the book are the Dean Corll, Dr. John Hill, and Sanford Radinsky murders; controversial cases involving the department’s crime lab; the killings of Randy Webster and Joe Campos Torres; and the Camp Logan, Texas Southern University, and Moody Park Riots
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