Butyl­trichlorido{2-[(diisopropyl­ammonio)­meth­yl]phen­yl}tin(IV) dichloro­methane monosolvate

The title compound, [Sn(C4H9)(C13H21N)Cl3]·CH2Cl2, was obtained by recrystallization of [2-(diisopropyl­amino­meth­yl)phen­yl]tin(IV) butyl dichloride from a CH2Cl2/n-hexane mixture (1:4 v/v) in the presence of ambient moisture. Partial hydrolysis led to the title compound, the hydro­chloric acid adduct of the dichloride, having a penta­coordinated Sn atom with a trigonal–bipyramidal C2SnCl3 core. The N atom of the 2-[(diisopropyl­ammonio)­meth­yl]phenyl ligand forms a strong intra­molecular N—H⋯Cl hydrogen bond, resulting in a zwitterionic species, [2-(iPr2HN+CH2)C6H4]SnBuCl3 −·CH2Cl2. Disorder was found in the n-butyl group, which was refined as disordered over three positions, with site occupancies of 0.22 (1), 0.51 (1) and 0.27 (2)

Substitutional disorder in a hypervalent diorganotin(IV) dihalide

The structure of bromidochloridobis[2-(dimethyl­amino­meth­yl)phen­yl]tin(IV), [SnBr0.65Cl1.35(C9H12N)2], contains two 2-(Me2NCH2)C6H4 units bonded to a Sn atom which lies on a twofold axis. The compound exhibits substitutional disorder of the halide atoms bonded to the Sn, with 1.35 occupancy for Cl and 0.65 for Br; it is isomorphous with the corresponding dichloride. The Sn atom is hexa­coordinated with a (C,N)2SnX 2 (X = Cl/Br) distorted octa­hedral core as a result of the strong intra­molecular N→Sn coordination trans to the Sn—X bonds (N1—Sn1—X1 = 165.8°). As a result of the inter­molecular contacts, viz. H⋯X and H⋯benzene inter­actions, the mol­ecules are arranged in a three-dimensional supra­molecular manner in the crystal structure

Group 12 metal aryl selenolates. Crystal and molecular structure of [2-(Et2NCH2)C6H4]2Se 2 and [2-(Me2NCH2)C6H 4Se]2M (M = Zn, Cd)

Diorganodiselenide [2-(Et2NCH2)C6H 4]2Se2 (1) was obtained by hydrolysis/oxidation of the corresponding [2-(Et2NCH2)C6H 4]SeLi derivative. The treatment of [2-(Et2NCH 2)C6H4]2Se2 with elemental sodium in THF resulted in [2-(Et2NCH2)C 6H4]SeNa (2). Reactions between alkali metal selenolates [2-(R2NCH2)C6H4]SeM′ (R = Me, Et; M′ = Li, Na) and MCl2 (M = Zn, Cd) in a 2:1 molar ratio resulted in the [2-(R2NCH2)C6H 4Se]2M species [R = Me, M = Zn (3), Cd (4); R = Et, M = Zn (5), Cd (6)]. The new compounds were characterized by multinuclear NMR ( 1H, 13C, 77Se, 113Cd) and mass spectrometry. The crystal and molecular structures of 1, 3 and 4 revealed monomeric species stabilized by N → Se (for 1) and N → M (for 3 and 4) intramolecular interactions. © 2010 Elsevier B.V. All rights reserved.Financial support from National University Research Council and Ministry of Education and Research of Romania (Research Projects CEx 11-55/2006 and PNII-ID 2404/2008) is greatly appreciated.Peer Reviewe

Synthesis, spectroscopic characterization, and structural studies of new Cu(I) and Cu(II) complexes containing organophosphorus ligands, and crystal structures of (Ph3P)(2)Cu S2PMe2 , (Ph3P)(2)Cu (OPPh2)(2)N , Cu (OPPh2)(2)N (2), and Cu (OPPh2)(SPPh2)N (2)

The Cu(I) complexes, (Ph3P)(2)CuL (L = [S2PMe2](-), [OSPR2](-) (R = Me, Ph), [(XPR2)(YPR'(2))N](-) (X, Y, R, R' = O, O, Ph, Ph; O, S, Ph, Ph; O, S, OEt, Ph; S, S, Me, Me)) and Cu(II) complexes, CuL2 (L = [(XPR2)(YPR'(2))N](-) (X, Y, R, R' = O, O, Ph, Ph; O, S, Ph, Ph)), have been prepared. The Cu(I) derivatives were characterized by multinuclear NMR spectroscopy and in two cases by X-ray crystallography. (Ph3P)(2)Cu[S2PMe2] (1) crystallizes in the orthorhombic space group P2(1)2(1)2(1) (No. 19) with cell parameters a = 9.782(2), b = 17.808(4), c = 20.216(4) Angstrom, V = 3521(6) Angstrom (3) and Z = 4, and (Ph3P)(2)Cu[(OPPh2)(2)N] (4) in the triclinic space group P (1) over bar (No. 2) with cell parameters a = 9.8079(2), b = 12.9141(3), c = 22.5666(5) Angstrom, alpha = 75.714(2), beta = 79.465(2), gamma = 68.2770(8)degrees, V = 2559.9(1) Angstrom (3) and Z = 2. In both cases the phosphorusligands are bidentate, thus resulting in monomeric molecules that contain tetrahedral CuP2S2 and CuP2O2 cores. The molecular structures of two of the Cu(II) derivatives were also determined. Cu[(OPPh2)(2)N](2) (8) and Cu[(OPPh2)(SPPh2)N](2) (9) crystallize in the triclinic space groupP (1)over bar (No. 2) with cell parameters a = 8.887(2), b = 10.739(2), c = 12.477(3) Angstrom, alpha = 77.61(3), beta = 76.15(5), gamma = 79.46(3)degrees,V = 1118.3(4) Angstrom (3) and Z = 1 for 8, and a = 9.626(2), b = 14.151(3), c = 24.752(5) Angstrom, alpha = 88.23(3), beta = 79.93(3), gamma = 89.77(3)degrees, V = 3181(1) Angstrom (3) and Z = 3 for 9. The moleculeof Cu[(OPPh2)(2)N](2) (8) has a planar CuO4 core, while in Cu[(OPPh2)(SPPh2)N](2) (9) both planar and tetrahedral copper cores are observed in a ratio of 1:2

Immunomodulatory Effect of Novel Electrospun Nanofibers Loaded with Doxycycline as an Adjuvant Treatment in Periodontitis

The immunomodulatory effect of a novel biomaterial obtained through electrospinning, based on polylactic acid (PLA) and nano-hydroxyapatite (nano-HAP), loaded with doxycycline (doxy) was evaluated in an animal model. The treatment capabilities as a local non-surgical treatment of periodontitis was investigated on the lower incisors of Wistar rats, after the induction of localized periodontitis using the ligature technique. Following the induction of the disease, the non-surgical treatment of scaling and root planing was applied, in conjunction with the application of the new material. The results of the treatment were evaluated clinically, using the tooth mobility and gingival index scores, as well as histologically. The salivary concentrations of matrix metalloproteinase 8 (MMP-8) and plasmatic concentrations of interleukin 1 (IL-1), interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF-α) were also monitored. Two weeks after the ligature application, the periodontal disease was successfully induced in rats. The application of the novel biomaterial obtained through electrospinning was proven to be more effective in improving the clinical parameters, while decreasing the salivary MMP-8 and plasmatic IL-1 and TNF-α concentrations, compared to the simple scaling and root planing. Thus, the novel electrospun biomaterial could be a strong candidate as an adjuvant to the non-surgical periodontal therapy