Frequency of paraoxonase 192/55 polymorphism in an Iranian population

Paraoxonase (PON1) is a serum enzyme that plays an important role in prevention of atherosclerosis and also protects against organophosphate-induced neurotoxicity. PON1 displays a high variablility in human populations. In this study, PON1-192 and -55 polymorphisms and correlation to serum PON1 activity were investigated in 132 healthy Iranian individuals from Isfahan province. The genotype frequencies for PON1-192 were approximately 48 (QQ), 42. (QR), and 10 (RR) and for PON1-55 17 (MM), 48 (ML), and 35 (LL). Thus, the frequencies of alleles R and L were 0.31 and 0.59, respectively. PON1 activity toward paraoxon was markedly affected in both polymorphic populations in the following order QQ < QR < RR genotype for PON1-192 and MM < ML < LL genotype for PON1-55. Neither polymorphism significantly affected PON1 activity toward phenylacetate. The RR/LL individuals had the highest PON1 activity and QQ/MM individuals the least. The QR/ML haplotype was the most frequent seen in Iranians, and the RR/MM and QR/MM haplotypes were absent in this population. In conclusion, the frequencies of PON1-192 and -55 polymorphisms in this Iranian population were different from those seen in other Asian populations from Japan and China but similar to those for European Caucasians. Copyright © Taylor & Francis Group, LLC

Shiga toxin targets the podocyte causing hemolytic uremic syndrome through endothelial complement activation

Background: Shiga toxin (Stx)-producing Escherichia coli hemolytic uremic syndrome (STEC-HUS) is the leading cause of acute kidney injury in children, with an associated mortality of up to 5%. The mechanisms underlying STEC-HUS and why the glomerular microvasculature is so susceptible to injury following systemic Stx infection are unclear. Methods: Transgenic mice were engineered to express the Stx receptor (Gb3) exclusively in their kidney podocytes (Pod-Gb3) and challenged with systemic Stx. Human glomerular cell models and kidney biopsies from patients with STEC-HUS were also studied. Findings: Stx-challenged Pod-Gb3 mice developed STEC-HUS. This was mediated by a reduction in podocyte vascular endothelial growth factor A (VEGF-A), which led to loss of glomerular endothelial cell (GEnC) glycocalyx, a reduction in GEnC inhibitory complement factor H binding, and local activation of the complement pathway. Early therapeutic inhibition of the terminal complement pathway with a C5 inhibitor rescued this podocyte-driven, Stx-induced HUS phenotype. Conclusions: This study potentially explains why systemic Stx exposure targets the glomerulus and supports the early use of terminal complement pathway inhibition in this devastating disease

Islamic Veiling Meets Fashion – Struggles and Translations

The political controversies surrounding Muslim veiling today involve specific rhetorical elements deriving from long histories of colonialism, post-colonialism and neo-colonialism, and Muslim responses to these. A number of different languages – political, religious, patriarchal, feminist, sectarian, aesthetic – often get mixed up when Muslim veiling is talked about by diverse types of people, both Muslim and non-Muslim. Sartorial fashion is also spoken about in multiple registers: in terms of aesthetics, commercial considerations, social distinction and stratification, art, design and creativity. Both veiling and fashion have non-verbal languages, too. This chapter looks into the relationships between languages of veiling and languages of fashion. What happens when veiling becomes fashionable? What happens when fashionable forms of veiling appear, and an Islamic fashion industry emerges? There are three relevant types of language use here: those within Muslim communities, those outside Muslim communities, and those operating between Muslim and non-Muslim communities. These are shaped by power struggles of many sorts. As Foucault recognized, languages shape, hide and (re)produce power relations, such as in Orientalist forms of representation (Said), and in localized forms of silencing subaltern groups like lower-class women (Spivak). Such struggles become more complex when fashion languages and veiling languages meet. Fashionable veiling, or veiling fashion, can be a powerful tool for a Muslim woman, but it can also be rejected as oppressive or demeaning. These contradictory and intertwined elements of veiling languages and fashion languages are subjected here to cultural-historical sociological analysis