Writhing Geometry of Open DNA

Motivated by recent experiments on DNA torsion-force-extension characteristics we consider the writhing geometry of open stiff molecules. We exhibit a cyclic motion which allows arbitrarily large twisting of the end of a molecule via an activated process. This process is suppressed for forces larger than femto-Newtons which allows us to show that experiments are sensitive to a generalization of the Calugareanu-White formula for the writhe. Using numerical methods we compare this formulation of the writhe with recent analytic calculations.Comment: 12 pages 10 figures. Revtex

A spatially distributed, physically-based modeling approach for estimating agricultural nitrate leaching to groundwater

Nitrogen-nitrate, while being fundamental for crop production, is of particular concern in the agricultural sector, as it can easily leach to the water table, worsening groundwater quality. Numerical models and Geographic Information System may support the estimation of nitrate leaching rates in space and time, to support sustainable agricultural management practices. In this paper, we present a module for the simulation of the processes involved in the nitrogen cycle in the unsaturated zone, including nitrate leaching. This module was developed taking steps from the ANIMO and EPIC model frameworks and coupled to the hydrological models integrated within the FREEWAT platform. As such, the nitrogen cycle module was then included in the FREEWAT platform. The developed module and the coupling approach were tested using a simple synthetic application, where we simulated nitrate leaching through the unsaturated zone for a sunflower crop irrigated district during a dry year. The results of the simulation allow the estimation of daily nitrate concentration values at the water table. These spatially distributed values may then be further used as input concentration in models for simulating solute transport in aquifers

Comment on "Elasticity Model of a Supercoiled DNA Molecule"

We perform simulations to numerically study the writhe distribution of a stiff polymer. We compare with analytic results of Bouchiat and Mezard (PRL 80 1556- (1998); cond-mat/9706050).Comment: 1 page, 1 figure revtex

DNA loop statistics and torsional modulus

The modelling of DNA mechanics under external constraints is discussed. Two analytical models are widely known, but disagree for instance on the value of the torsional modulus. The origin of this embarassing situation is located in the concept of writhe. This letter presents a unified model for DNA establishing a relation between the different approaches. I show that the writhe created by the loops of DNA is at the origin of the discrepancy. To take this into account, I propose a new treatment of loop statistics based on numerical simulations using the most general formula for the writhe, and on analytic calculations with only one fit parameter. One can then compute the value of the torsional modulus of DNA without the need of any cut-off.Comment: 8 pages, 1 figure. Accepted by Europhysics Letter

Interactive Search and Exploration in Online Discussion Forums Using Multimodal Embeddings

In this paper we present a novel interactive multimodal learning system, which facilitates search and exploration in large networks of social multimedia users. It allows the analyst to identify and select users of interest, and to find similar users in an interactive learning setting. Our approach is based on novel multimodal representations of users, words and concepts, which we simultaneously learn by deploying a general-purpose neural embedding model. We show these representations to be useful not only for categorizing users, but also for automatically generating user and community profiles. Inspired by traditional summarization approaches, we create the profiles by selecting diverse and representative content from all available modalities, i.e. the text, image and user modality. The usefulness of the approach is evaluated using artificial actors, which simulate user behavior in a relevance feedback scenario. Multiple experiments were conducted in order to evaluate the quality of our multimodal representations, to compare different embedding strategies, and to determine the importance of different modalities. We demonstrate the capabilities of the proposed approach on two different multimedia collections originating from the violent online extremism forum Stormfront and the microblogging platform Twitter, which are particularly interesting due to the high semantic level of the discussions they feature

VHCF Response of H13 Steels Produced with Different Manufacturing Processes

Experimental results have recently shown that failures at stress amplitude below the conventional fatigue limit and at Very High Cycle Fatigue (VHCF) are possible. In case of high-strength steels, VHCF failures generally originate from defects/inclusions present within the material and, consequently, the defect population properties (size and quantity) significantly affect the VHCF response of high-strength steels. Different refinement processes are commonly adopted in order to improve steel cleanliness: among the other, the ElectroSlag Remelting (ESR) process allows to obtain very clean high-strength steels, thus possibly inducing a significant enhancement of the VHCF response. The present paper aims at investigating the actual effect of the ESR process on the VHCF behavior of an AISI H13 steel. Fully reversed ultrasonic tension-compression tests are carried out on hourglass specimens manufactured with and without the ESR process. The estimated P-S-N curves highlight the positive effects of the ESR process on the VHCF response of the investigated H13 steel

Importance of the induced recharge term in riverbank filtration: Hydrodynamics, hydrochemical, and numerical modelling investigations

While ensuring adequate drinking water supply is increasingly being a worldwide challenging need, managed aquifer recharge (MAR) schemes may provide reliable solutions in order to guarantee safe and continuous supply of water. This is particularly true in riverbank filtration (RBF) schemes. Several studies aimed at addressing the treatment capabilities of such schemes, but induced aquifer recharge hydrodynamics from surface water bodies caused by pumping wells is seldom analysed and quantified. In this study, after presenting a detailed description of the Serchio River RBF site, we used a multidisciplinary approach entailing hydrodynamics, hydrochemical, and numerical modelling methods in order to evaluate the change in recharge from the Serchio river to the aquifer due to the building of the RBF infrastructures along the Serchio river (Lucca, Italy). In this way, we estimated the increase in aquifer recharge and the ratio of bank filtrate to ambient groundwater abstracted at such RBF scheme. Results highlight that in present conditions the main source of the RBF pumping wells is the Serchio River water and that the groundwater at the Sant’Alessio plain is mainly characterized by mixing between precipitation occurring in the higher part of the plain and the River water. Based on chemical mixing, a precautionary amount of abstracted Serchio River water is estimated to be on average 13.6 Mm3 /year, which is 85% of the total amount of water abstracted in a year (~16 Mm3). RBF is a worldwide recognized MAR technique for supplying good quality and reliable amount of water. As in several cases and countries the induced recharge component is not duly acknowledged, the authors suggest including the term “induced” in the definition of this type of MAR technique (to become then IRBF). Thus, clear reference may be made to the fact that the bank filtration is not completely due to natural recharge, as in many cases of surface water/groundwater interactions, but it may be partly/almost all human-made