Presence of recreational drugs according to gestational time period analysed.

<p>MDMA: methylenedioxymethamphetamine.</p><p>Presence of recreational drugs according to gestational time period analysed.</p

Number of women recruited per group.

<p>NTD: neural tube defect.</p><p>* Transverse limb defects (7 cases), bowel atresia (3 cases: duodenal atresia or ileal atresia) .</p><p>** Trisomy 21 (10 cases), trisomy 18 (2 cases), 1 case each of trisomy 13, 45 X0, XXX, triploidy, unbalanced translocation, 15q deletion, terminal deletion of chromosome 5.</p><p>Δ Skeletal dysplasia (8 cases), multiple abnormalities (6 cases), autosomal dominant polycystic kidney disease (2 cases).</p><p>Cardiac anomalies included large septal defects, hypoplastic left or right heart, Ebstein's anomaly, tetralogy of Fallot, transposition of the great arteries, left atrial isomerism, valvular atresias and double outlet right ventricle.</p><p>Other CNS anomalies included agenesis of corpus callosum, Dandy Walker spectrum, cerebellar hypoplasia, posterior fossa cyst, porencephalic cyst, severe ventriculomegaly and holoprosencephaly.</p><p>Renal anomaly: multicystic or dysplastic kidneys, lower urinary outflow tract obstruction.</p><p>Number of women recruited per group.</p

Fetal anomalies and non-recreational drug use.

<p>OR: Odds Ratio.</p><p>Missing cases were excluded.</p><p>Fetal anomalies and non-recreational drug use.</p

Binary logistic regression.

<p><b>Dependent variable is fetus with gastroschisis.</b></p><p>Binary logistic regression.</p

Population demographics.

<p>NSAID: non-steroidal anti-inflammatory drug; df: degrees of freedom.</p><p>*Reported codeine/dihydrocodeine use.</p><p>Population demographics.</p

Social factors associated with recreational drug use.

<p>Δsmoking currently or in the last 6 months; OR: Odds Ratio; CI: confidence interval; *Mann-Whitney U test; **Chi squared test.</p><p>Social factors associated with recreational drug use.</p

Type of fetal anomaly and recreational drug use.

<p>OR: Odds Ratio compared to Normal Control Group; CI: confidence interval; NTD: neural tube defect; df: degrees of freedom.</p><p>Type of fetal anomaly and recreational drug use.</p