4 research outputs found
Project INTEGRATE: Developing a framework to guide design, implementation and evaluation of people-centred integrated care processes
Background: People-centred integrated care is an acknowledged approach to improve the quality and effectiveness of health systems in delivering care around people’s needs and preferences.
Nevertheless, more guidance on how to effectively design, implement and evaluate the care process of
people-centred integrated care services is needed. Under Project INTEGRATE, a framework was developed
to guide managers in the assessment, transformation and delivery of these health service innovations.
Methods: The framework is a product of the synthesis of operations, service and project management
literature, relevant health care literature, and the analysis of four good practice integrated care case
studies analysed under Project INTEGRATE. A first iteration of the framework was developed and then
applied to one of the integrated care case studies to test its validity and utility.
Results and Discussion: The tool combines a number of important considerations and criteria that have
not been previously included in integrated care assessment frameworks, allowing for a pragmatic and
comprehensive analysis of the care process.
Conclusion: This framework can be used as a stand-alone or combined tool to guide managers to plan and
evaluate the care process design of people-centred integrated care services; future work should apply
this tool to other settings
Artificial pancreas systems for people with type 2 diabetes: Conception and design of the european CLOSE project
In the last 10 years tremendous progress has been made in the development of artificial pancreas (AP) systems for people
with type 1 diabetes (T1D). The pan-European consortium CLOSE (Automated Glucose Control at Home for People with
Chronic Disease) is aiming to develop integrated AP solutions (APplus) tailored to the needs of people with type 2 diabetes
(T2D). APplus comprises a product and service package complementing the AP system by obligatory training as well as home
visits and telemedical consultations on demand. Outcome predictors and performance indicators shall help to identify people
who could benefit most from AP usage and facilitate the measurement of AP impact in diabetes care. In a first step CLOSE
will establish a scalable APplus model case working at the interface between patients, homecare service providers, and payers
in France. CLOSE will then scale up APplus by pursuing geographic distribution, targeting additional audiences, and enhancing
AP functionalities and interconnectedness. By being part of the European Institute of Innovation and Technology (EIT)
Health public-private partnership, CLOSE is committed to the EIT “knowledge triangle” pursuing the integrated advancement
of technology, education, and business creation. Putting stakeholders, education, and impact into the center of APplus
advancement is considered key for achieving wide AP use in T2D care
Project INTEGRATE: Developing a framework to guide design, implementation and evaluation of people-centred integrated care processes
Background: People-centred integrated care is an acknowledged approach to improve the quality and effectiveness of health systems in delivering care around people’s needs and preferences.
Nevertheless, more guidance on how to effectively design, implement and evaluate the care process of
people-centred integrated care services is needed. Under Project INTEGRATE, a framework was developed
to guide managers in the assessment, transformation and delivery of these health service innovations.
Methods: The framework is a product of the synthesis of operations, service and project management
literature, relevant health care literature, and the analysis of four good practice integrated care case
studies analysed under Project INTEGRATE. A first iteration of the framework was developed and then
applied to one of the integrated care case studies to test its validity and utility.
Results and Discussion: The tool combines a number of important considerations and criteria that have
not been previously included in integrated care assessment frameworks, allowing for a pragmatic and
comprehensive analysis of the care process.
Conclusion: This framework can be used as a stand-alone or combined tool to guide managers to plan and
evaluate the care process design of people-centred integrated care services; future work should apply
this tool to other settings
A multicentre evaluation of the NG-test DetecTool OXA-23 for the rapid detection of OXA-23 carbapenemase directly from blood cultures
Objectives
A multicentre study evaluating NG-Test DetecTool OXA-23 for the detection of OXA-23 carbapenemase directly from positive blood cultures (PBCs).
Methods
The NG-Test DetecTool OXA-23 is an immunoassay that integrates a sample preparation device. We evaluated NG-Test DetecTool OXA-23 on 189 spiked and 126 clinical PBCs. The clinical samples’ standard-of-care procedure consisted of bacterial identification from the first day of positivity by MALDI-TOF MS, conventional culture and antimicrobial susceptibility testing. The immunoassay results were verified molecularly. The strains used for the spiked samples consisted of well-characterized Acinetobacter baumannii and Proteus mirabilis strains.
Results
The NG-Test DetecTool OXA-23 was evaluated on 315 PBCs and revealed sensitivity of 100% (95% CI: 98.21%–100.00%) and specificity of 100% (95% CI: 96.73%–100.00%). It provided 204 true-positive results for OXA-23 in 196 bottles with carbapenem-resistant A. baumannii (CRAB) and 8 bottles with carbapenem-resistant P. mirabilis and also provided 111 true-negative results. There were no false-positive and no false-negative results. Among the 315 PBCs studied, 83 clinical blood cultures collected in the ICU of a Greek university hospital, which were tested prospectively, all yielded CRAB, and OXA-23 was correctly detected in all samples from the first day of positivity using the NG-Test DetecTool OXA-23.
Conclusions
The NG-Test DetecTool OXA-23 has exhibited excellent sensitivity and specificity for OXA-23 detection in PBCs and can provide valuable information for appropriate selection of antibiotic therapy and early implementation of infection control measures